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4th Edition of World Congress on Infectious Diseases

June 21-22, 2023 | Rome, Italy

June 21 -22, 2023 | Rome, Italy
Infection 2023

Bouklata Nada

Speaker at World Congress on Infectious Diseases 2023 - Bouklata Nada
National Institut of Hygiene (INH), Morocco
Title : Genetic diversity and molecular epidemiology of mycobacterium tuberculosis from pleural specimen in Morocco


Development of pleural form of tuberculosis is still poorly understood, particularly in quite high-endemic countries like Morocco. Genotypic studies may help understanding the transmission routes of Mycobacterium tuberculosis strains in pleural TB patients.

Material and Methods: Among 156 new pleural TB cases, 28 were culture positive (17.9%). 7 distinct spoligotypes belonged to four spoligotype families: Latin-American & Mediterranean (LAM) (13/28) of the isolates, Haarlem (H) (10/28), and T group (T) (2/28), and Beijing (3/28). MIRU-VNTR typing subdivided the largest spoligotype cluster, and defined a total of 3 clustered isolates.

Conclusions: Within the study limits, these proportions were similar to those found among pulmonary TB (PTB) cases in Morocco. Of note, the three (03) multi-drug (MDR) resistant isolate were Beijing type, exactly matching the 24-locus type of a major European-Russian Beijing MDR clone.

Key words: Mycobacterium Tuberculosis, Extrapulmonary-TB, resistance, spoligotyping, 24-locus based MIRU-VNTR typing.


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