Title : Nanotechnology appears in control polymicrobial biofilms
Polymicrobial biofilms are associated with a wide range of infections, present in medical devices such as catheters and joint prostheses, valves, and in chronic tissue infections, which occur mainly in patients with cystic fibrosis, and oral infections, among others, as well as or co-infections with various fungi, the socalled polymicrobial biofilms. Tolerance of these biofilms against antimicrobials, biocides, and antiseptics is a common behavior of biofilm formation, and their physiology contributes to antimicrobial tolerance due to physical structure, gene expression, multidrug efflux pumps, changes in metabolism, response to stress regulation, and quorum sensing molecules. These biofilm survival mechanisms related to treatment failure, due to prolonged schemes, and hospitalization, are considered a public health problem, especially the polymicrobial biofilms. For this reason, Nanotechnology emerges as an alternative in the effective treatment against biofilms, due to the ability to cross the biofilm and cause cell death, nanoparticles can act on specific microbial cells, causing cell death by oxidative damage, membrane disruption, inhibiting enzymes, DNA damage, protein inactivation and changes in biofilm gene expression, in addition to reducing the dose and toxic effects on the patient. Given the above, we emphasize the need for new therapies that can overcome multiple resistance to existing antimicrobials, especially in highly resistant monospecies and polymicrobial biofilms.
Keywords: Nanotechnology, biofilms, polymicrobial biofilms, antimicrobials.
Audience take away:
• Explain how the audience will be able to use what they learned? It can be used in countless ways in basic and applied science by understanding how nanotechnology is being applied effectively in the treatment of biofilms.
• How will this help the audience in your work? Seeing nanotechnology as an alternative treatment in research, as well as in the treatment of patients, especially nosocomial infections.
• Is this research that other faculty could use to expand their research or teaching? Yes, there are many groups in the world already using these surveys.
• Does it provide a practical solution to a problem that might simplify or make a designer's Sample Abstract Template job more efficient? Nanotechnology provides an alternative yes solution for the treatment of polymicrobial biofilms that are highly resistant.
• This will improve the accuracy of a design or provide new information to aid in a design problem? I believe they did know about polymicrobial interactions and new treatments for them that could be similarly applied in other projects.
• List all other benefits.