Changes in temperature, rainfall and humidity due to global warming affect mosquito-borne disease transmission. However, coastal areas are also influenced by the expansion of brackish water mosquito habitats as a result of global warming leading to higher sea levels. Typical fres [....] » Read More
The genetic diversity and allele frequencies of MSP-1, MSP-2 and glutamtew rich protein of P. falciparum and consequence on malaria control was investigated in some parts of Cross River State, Nigeria. A total of 230 finger prick samples of blood were examined for the presence of [....] » Read More
Objectives: The objective of this study was to describe the epidemiology of malaria in Trinidad and Tobago from 1997 to 2019 and to make recommendations for prevention and control on a background of migration and climate change. Study design: A retrospective review of surveill [....] » Read More
Tuberculosis (TB), primarily affecting the lungs, is a chronic infectious disease caused by Mycobacterium tuberculosis. While pulmonary TB remains the most common presentation, extrapulmonary manifestations, particularly involving the musculoskeletal system, contribute significan [....] » Read More
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Title : The Role of the Humoral Innate Immune System in Evasion of Streptococcus pyogenes Infections
Francis J. Castellino, University of Notre Dame, United States
The human innate immune system plays a central role in controlling the virulence of Streptococcal pyogenes (GAS) infections. Important participants of the humoral response to these infections are the coagulation, complement, and inflammatory systems. GAS responds to h [....] » Read More
Title : 2000 years of pandemics: Past, Present and Future
Claudia Ferreira, Biophytis Sorbonne, France
A pandemic is considered as an outbreak of a disease occurring over a wide geographic area, crossing national borders, and affecting a high proportion of the world. During the 1st millennium AD, three main pandemics emerged. The Antonine Plague (165-190 AD), caused by hemorrhagic [....] » Read More
Title : Current topics of adult COVID-19, Influenza, and RS virus patients in Japan
Seki Masafumi, Saitama Medical University International Medical Center, Japan
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Title : Risk factors of mortality and development of a scoring system for predicting mortality among patients with leptospirosis
Goutham Krishna T.C, Government Medical College, India
Background Leptospirosis, a potentially fatal zoonotic infection, has been on the rise in Kerala, India particularly among individuals involved in water-related occupations and activities. With increasing incidence and mortality rates, there is an urgent need to identify key r [....] » Read More
Title : Latin America and the Caribbean consortium: Connecting excellence to enhance the skills base of local research teams in emerging infectious diseases
Fernando Rubinstein, Instituto de Efectividad Clinica y Sanitaria, Argentina
Introduction: To respond to the emerging Zika outbreak, a community of practice (CoP) was created to provide support to implement high-quality, coherent research in affected communities in Latin America and the Caribbean (LAC). The achievements of this CoP laid the groundwork for [....] » Read More
Title : Laparoscopic heller myotomy with anterior fundoplication in an elderly male patient with achalasia and coexisting miliary tuberculosis: A case report
Abraham P. Bayan , Capitol Medical Center, Philippines
Background: This case report aims to present the applicability and safety of laparoscopic Heller myotomy with anterior fundoplication in an elderly male patient with achalasia and coexisting military tuberculosis. Although the exact cause of achalasia has not been determined, the [....] » Read More
Title : Th1/Th2/Th17 cytokine profile among different stages of COVID-19 infection
Gaurav Gupta, AIIMS, India
Aim: to characterize Th1/Th2/Th17 cytokine profile (IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-?, and IL-17A) among different stages of COVID-19 infection. Methods: This was a cross-sectional study which included 6 healthy individuals and 68 patients who were admitted with COVI [....] » Read More
Title : The influence of evolving land covers on Scrub typhus spread in Nan Province, Thailand (2003-2019)
Nolwenn Blache, Vetagro Sup, France
Scrub typhus is a vector-borne disease caused by Orientia tsutsugamushi and transmitted by chigger mites of the genus Leptotrombidium. Endemic to the tsutsugamushi triangle, including Japan, Southeast Asia, and Australia, scrub typhus affects up to 77% of people in some regions o [....] » Read More
Title : Universal PCR assays to detect Candida FKS and ERG11 mutations
Cheung Yuk Yam, Hong Kong Metropolitan University, Hong Kong
The emergence of antifungal resistance in Candida species presents significant challenges in managing infections, particularly among immunocompromised patients. This study aimed to develop rapid molecular assays for detecting mutations in the FKS genes across four clinically sign [....] » Read More
Title : Foot-and-mouth disease virus antigenic landscape and reduced immunogenicity elucidated in atomic detail
Michiel Harmsen, Wageningen University and Research, Netherlands
Unlike most other picornaviruses, foot-and-mouth disease (FMD) intact virions (146S) dissociate easily into small pentameric subunits (12S). This causes a dramatically reduced protective efficacy of vaccines based on authentic FMDV particles. Although this has been observed for d [....] » Read More
Title : A single center retrospective study on the incidence and clinical outcomes of patients infected with klebsiella pneumoniae carbapenemase (KPC)-producing klebsiella pneumoniae
Kevin Cezar A. Estacio, Dr. Paulino J. Garcia Memorial Research Medical Center, Philippines
Introduction: Currently, one of the most significant nosocomial pathogens is Klebsiella pneumoniae strains that produce carbapenemase, in fact it is one of the most prevalent carbapenemase genes worldwide. Its rise also become a major global public health concern, and the best c [....] » Read More
Title : Incidence of acute pancreatitis among patients with moderate to severe leptospirosis and its clinical outcomes: A single center retrospective study in a tertiary hospital
Karizza Angeles, Dr. Paulino J. Garcia Memorial Research Medical Center, Philippines
Introduction: Acute pancreatitis is considered as an uncommon complication of leptospirosis. However, literatures suggested that this condition still occurs among leptospirosis patients. This study aims to determine the incidence of acute pancreatitis in moderate to sever [....] » Read More
Title : Overlooked possible menace to life also known as PML
Alejandro Carmona Casillas, University of Puerto Rico, Puerto Rico
Introduction: Progressive Multifocal Leukoencephalopathy (PML) is a relatively rare manifestation of immunosuppressed patients due to medication or diseases such as HIV/AIDS. PML arises from the reactivation of the human polyomavirus, more commonly known as JC viru [....] » Read More
Title : Conservative management of paediatric atypical necrotising cervical lymphadenitis: A case report
Tapan Parikh, Oxford NHS Foundation Trust, United Kingdom
Introduction: This case report describes the presentation, investigation, and non-surgical management of an unusual case of unilateral necrotising cervical lymphadenitis. A two-year-old girl had a three-month history of left-sided submandibular swelling which was managed by her l [....] » Read More