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4th Edition of World Congress on Infectious Diseases

June 21-22, 2023 | Rome, Italy

June 21 -22, 2023 | Rome, Italy
Infection 2023

Maria Luisa R. Maranan

Speaker at World Congress on Infectious Diseases 2023 - Maria Luisa R. Maranan
San Lazaro Hospital, Philippines
Title : Prevalence, clinical features and outcomes of hepatitis b and hepatitis c co-infections among HIV-positive adults in a philippine tertiary hospital from january 2015 to december 2019

Abstract:

Introduction: The Philippines is one of the countries with the fastest rising growth rate of HIV in the Asia Pacific. HIV, HBV and HCV have similarities in terms of risk factors and transmission routes, hence co-infection with HBV and/or HCV are said to be common in HIV-positive patients. Despite the high prevalence of HBV and HCV in the Philippines, there is limited data regarding HBV and HCV co-infections in PLHIV in the Philippines. This study aims to identify the prevalence, socio-demographic profile, clinical features and outcomes of HBV and HCV co-infections among HIV positive patients in a Philippine Tertiary Hospital.
Objective: To describe the prevalence, socio-demographic profile, clinical features and outcomes of HBV and HCV co-infections among HIV-positive patients at H4 Department of San Lazaro Hospital.
Design: A retrospective, observational, cross-sectional study was carried out between January 2015- December 2019.
Setting: A HIV treatment facility in a National Tertiary Infectious Disease Hospital in the Philippines.
Patients: The study included all HIV-positive patients with Hepatitis B and Hepatitis C co-infections enrolled during January 2015 – December 2019.
Interventions: No experimental interventions were carried out.
Results: Among 1,658 HIV-positive patients, the prevalence of HIV/HBV co-infection was 12% and the prevalence of HIV/HCV co-infections was 0.4%. There were no triple co-infections of HIV/HBV/HCV in our study population. The majority of patients with hepatitis co-infections were male (99.4%) and the most common mode of transmission is homosexual contact (68%). Both HIV/HBV and HIV/HCV patients exhibited mild elevations of serum transaminases. Non-invasive fibrosis scores were suggestive of significant fibrosis in 17.3% and were associated with cirrhosis in 11.3%. The rate of mortality in HIV-HBV co-infection was 28.4% while the mortality rate of HIV-HCV co-infection was 16.7%.
Conclusions: The prevalence of HBV among HIV patients in this study was lower than that of the reported prevalence of the general population in the Philippines. Our results showed a higher prevalence of HIV/HBV co-infection as compared to the median co-infection rate of Sub-Saharan Africa. Furthermore, the prevalence of HCV among HIV patients in our setting is very low, which can be attributable to the low IDU in this population. Fibrosis and cirrhosis were noted among HIV/HBV patients based on non-invasive fibrosis scoring. Because of increased mortality in HIV/HBV, the use of dual active antiretrovirals for the suppression of HIV-HBV should be prioritized. Vaccination and screening as well as surveillance of patients with hepatitis co-infections among HIV positive patients should be stringently enforced in HIV treatment facilities.

Audience take away:
• Provide local data on the prevalence of Hepatitis B and C Co-Infections among HIV-positive adults in a third world country with high HIV burden.
• Examine the demographics, clinical characteristic of PLHIV with HBV and HCV co-infections.
• Determine the clinical outcomes of PLHIV with HBV and HCV co-infections residing in a lower middle-income country such as the Philippines.

Biography:

Dr. Maria Luisa R. Maranan studied Bachelor of Science in Biology (Major in Zoology) at the University of the Philippines Los Ba┼łos. She earned her Medical degree from the University of the East Ramon Magsaysay Memorial Medical Center and finished her Internal Medicine residency training at The Medical City, Philippines. After graduating from fellowship training at San Lazaro Hospital, she is currently an Adult Infectious Disease Specialist practicing in Laguna, Philippines.

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