HYBRID EVENT: You can participate in person at Paris, France or Virtually from your home or work.

6th Edition of World Congress on Infectious Diseases

June 24-26, 2024 | Paris, France

June 24 -26, 2024 | Paris, France
Infection 2024

Aishwarya Vyas

Speaker at Infectious Diseases Conferences - Aishwarya Vyas
SMS Medical College, India
Title : A cohort study of the spectrum of coagulopathy in acute sepsis and its correlation with physiological scores and outcome


Purpose: To evaluate the spectrum of coagulopathy in acute sepsis and to correlate it with sequential physiological scores (SOFA & APACHE II) and compare the findings among survivors and non-survivors. 
DESIGN: Prospective cohort  

Methods: It is a prospective cohort study comparing the requirement of mechanical ventilation, ionotropic support, need of Intensive care, duration of hospitalization, SOFA and APACHE-II scores with various markers of coagulation and fibrinolysis among survivors and non-survivors of sepsis.  The study is conducted at a tertiary care hospital where 60 cases of sepsis have been studied. Among them, 29 were culture positive and 32 were culture negative.

Results: The most common microbial pathogen causing sepsis was Klebsiella(21.65%) with the most common site being respiratory tract(45%). When we compared the coagulation profile in Survivors and Non-Survivors, all coagulation parameters showed statistically significant difference between the two groups. Here, AT III, Protein-C and Protein-S are significantly decreased in non-survivor group and APTT, PT, INR, TT, FDP, D-Dimer, S Fibrinogen are significantly increased in non-survivor group (p-value<0.05).

Conclusion: In addition to predictive scoring system(SOFA, APACHE II), derangements in coagulation parameters may be used as a predictive tool to determine outcome in terms of severity of the disease and mortality in sepsis.


Dr. Aishwarya Vyas studied MBBS at the SMS Medical College Jaipur, India and graduated as MD in 2022. She then joined the Cardiology fellowship training at the same college. She was among the national toppers for both MBBS and postgraduate entrance exams.