Title : Atypical cytokine profile in early SARS-CoV-2 infection may indicate progression from mild to moderate disease: Possible role for IL-22
Abstract:
The coronavirus pandemic is still a major public health problem worldwide. It was started in Wuhan (a city in China), and the individuals started reporting the clinical manifestations were fever (moderate to high), dry cough, body aches, diarrhea, and headache. Usually, disease manifestation is mild to moderate with 6-8 weeks of recovery. Mild disease may be accompanied by dyspnea and hypoxia with/without radiological evidence in the lungs. Moderate cases usually have dyspnea with hypoxia and usually show an altered cytokine pattern. Severe cases of Covid-19 exhibit acute respiratory distress syndrome (ARDS), septic shock, and cytokine storm which may lead to multiple organ failures and eventually death. Therefore, we undertook this case-control study to determine the immunopathogenesis of COVID-19. The study aimed to determine T cell subtypes and cytokines in COVID-19 patients with mild to severe disease and compare them between patients who had recovered and those who had progressed to moderate to severe disease.
