Abstract:
Virus infection triggers rapid induction of antiviral and inflammatory genes in infected cells, leading to an antiviral state in the host. Inflammation, in the early stages of infection, is helpful; however, hyperinflammation can contribute to the pathogenesis. Our lab has been studying the fine balance between the antiviral and inflammatory arms of the host-virus interaction. Studies using cells and mice clearly identified new ways the host can control the inflammatory responses to curb cytokine storm. These studies have translational impacts against specific respiratory viruses.
Biography:
Saurabh Chattopadhyay, Ph.D., is an associate professor in the Department of Microbiology, Immunology, and Molecular Genetics at the University of Kentucky (UK) College of Medicine, Lexington, Kentucky, USA. He is a viral immunologist studying respiratory virus infection and its interaction with host immune responses. Research in his laboratory is funded by the National Institutes of Health, Ohio Department of Health, Center for Disease Control, and American Heart Association. He graduated from the Indian Institute of Technology Delhi in Biotechnology and did a postdoctoral fellowship in Virology at the Cleveland Clinic. Before moving to UK, he was an associate professor at the University of Toledo College of Medicine.
