Title : Descriptive analysis of coagulation status markers and their clinical implications in elderly patients with COVID-19
Abstract:
Introduction and objectives: COVID-19 induces a state of hypercoagulability, with advanced age identified as a significant risk factor for infection. The interplay between hypercoagulability and advanced age has far-reaching implications for the clinical course of COVID-19. This study attempts to explore the impact of coagulation status markers on the clinical course of elderly patients with COVID-19, specifically within the setting of Dr. Wahidin Sudirohusodo Central General Hospital.
Methods: This analytical descriptive study used chi-squared test or Fisher's exact test analysis and included a sample of 159 elderly patients aged 60 years or older. Thorough data extraction was conducted from the medical records of individuals admitted with COVID-19 to Dr. Wahidin Sudirohusodo Central General Hospital between January and June 2021. Coagulation parameters studied included platelet count, PT, APTT, and D-dimer. Clinical parameters evaluated included the distinction between ICU and non-ICU treatment, with corresponding clinical outcomes assessed by mortality and survival rates. A p-value below 0.05 was considered indicative of statistical significance.
Results: Of the 159 subjects aged 60 years and older, 103 individuals (64.8%) received non-ICU care, while 56 (35.2%) received ICU care. Of these subjects, 119 (74.8%) survived, whereas 40 (25.2%) succumbed to the disease. Notably, no discernible correlation was observed between coagulation parameters and clinical outcomes. Abnormal PT and APTT values were predominantly identified in subjects who did not survive (p-value 0.035 and p-value 0.023, respectively).
Conclusions: The results suggest that coagulation parameters may not significantly influence the clinical course of elderly patients with COVID-19. However, mortality appears to be associated with abnormal PT and APTT levels.
