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6th Edition of World Congress on Infectious Diseases

June 24-26, 2024 | Paris, France

June 24 -26, 2024 | Paris, France
Infection 2024

Yaun Shi

Speaker at Infection Conferences - Yaun Shi
Children’s Hospital of Chongqing Medical University, China
Title : IL-27 as a biomarker for distinguishing between necrotizing enterocolitis and highly suspected early-onset food protein-induced enterocolitis syndrome


Background: The initial clinical manifestations and abdominal imagines of neonates with necrotizing enterocolitis (NEC) and food protein-induced enterocolitis syndrome (FPIES) are sometimes similar, however, their prognosis and therapies are different. We aimed to evaluate the utility of interleukin(IL)-27 as an early differentiation marker between NEC and highly suspected early onset (HSEO)-FPIES.

Methods: The samples used in this study were all from the neonatal diagnosis center of Children’s Hospital. In the case-control study, neonates with jaundice (n=8), HSEO-FPIES (n=9),and NEC (n=13) were enrolled to determine the serum IL-27 levels using commercial enzyme-linked immune sorbent assay (ELISA) kits. In the validation cohort study, we included NEC (n = 87), HSEO-FPIES (n = 62),and jaundice(control, n = 54) groups to analyze the diagnostic efficiency of IL-27 for discriminating between NEC and FPIES using a receiver operating characteristic (ROC) curve.

Findings: In the case-control study, IL-27 levels were higher in the NEC group than in the HSEO-FPIES group (p=0·005).In the cohort study, the area under the ROC curve (AUC) ofIL-27 for differentiating NEC from HSEO-FPIES, was 0·878, which was higher thanIL-6 (0·761),C-reactive protein (0·800), white blood cell count (0·637), neutrophils (0·765), lymphocytes (0·782), neutrophil to lymphocyte ratio (0·781), and platelet count (0·729).

Interpretation: Serum IL-27 is a novel biomarker that may potentially discriminate NEC from HSEO-FPIES in neonates. FPIES is  a relatively newly identified entity in the neonatal period and in some cases it remains difficult for early differentiation of HSEO-FPIES and NEC .To our knowledge, Our study was the first to explore a biomarker for discriminating between NEC and HSEO-FPIES in neonates in a relatively large sample size and may potentially help the neonatologists in decisions making


Shi Yuan, doctor of medicine, professor, he director of the neonatal diagnosis and treatment center of the Children's Hospital of Chongqing Medical University, the leader of the national key clinical specialty, Deputy Leader of the Neonatology Group, served as editor or guest executive editor of SCI journals "BMC Pediatrics", "BMC Neurology", "Trials",  Dr.Shi presided over more than 10 scientific research projects including the National Key Research and Development Program of China,National Natural Science Foundation, and the research funding from which is more than 30 million yuan and published more than 50 o SCI papers such as “Lancet Infectious Disease”, “JAMA Pediatrics”, “Lancet Child & Adolescent Health”.