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6th Edition of World Congress on Infectious Diseases

June 24-26, 2024 | Paris, France

June 24 -26, 2024 | Paris, France
Infection 2024

Tsegaye Alemayehu

Speaker at World Congress on Infectious Diseases 2024 - Tsegaye Alemayehu
School of Medical Laboratory Science, Ethiopia
Title : Metallo-ß- lactamase resistance gram negative bacteria from a clinical specimen in Sidama, Ethiopia


Background: Metallo-beta lactamase resistance is one of the carbapenem resistances that worsen the world nowadays. A new variant of carbapenem-resistant has only limited reports from Africa including Ethiopia. This study aimed to determine Metallo -ß- lactamase resistance Gram-negative bacteria in Hawassa University Comprehensive Specialized Hospital January–June 2023.

Method: a cross-sectional study was conducted in which consecutive patients infected with Gram-negative bacteria were included in the study. A structured questionnaire was used to collect the data with oriented nurses if the patients/or caregivers gave consent to participate in the study. Clinical specimens were processed based on the standard operating procedure of the Microbiology laboratory and Clinical laboratory standard institute guidelines.  Statistical Software for Social Science (SPSS) version 21 was used for data entry and analysis. Descriptive statistics and logistic regression were used to interpret the data. The odds ratio at 95% confidence interval (CI) and p-value < 0.05 were taken as a statistically significant association.

Result: Our study included 153 isolates from different specimens, 83 (54.2 %) were from male patients and 70 (45.8 %) were from females. K. pneumonia was the predominant 43, followed by E. coli 32, Acinetobacter spp 25, Pseudomonas spp 15, E. agglomerus 9, K. ozaenae 6, E. cloacae 5, K. oxytoca 4,( K. rhinoscleromatis, P. mirabilis and M. morganii) 3, P. stuartii 2 and (Citrobacter spp & P. vulgaris) 1. The rates of multi, extensive and pan-drug resistance bacteria accounted for 83.7%, 50.3%, and 17.0%, respectively. Carbapenem resistance was 21 (13.7%), of this 7.2 % were Enterobacteriaceae, 5.2 % were Acetinobacter spp. and 1.3 % Pseudomonas spp. Metallo-beta-lactamase was 17 (11.1%), of this, Enterobacteriaceae were 9(5.9%), Acetinobacter spp. 7(4.6%), and Pseudomonas spp. 1(0.7%). There were no variables statistically significantly associated with metallo-beta-lactamase-resistant

Conclusion: Our study revealed that Metallo-beta-lactamase resistance was circulating in the study area. There was a high rate of carbapenem resistance, multi, extensive and pan-drug resistance. Therefore, a measure should be taken to alleviate the emerging threat that leaves the patients without the option of treatment.


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