HYBRID EVENT: You can participate in person at Paris, France or Virtually from your home or work.

6th Edition of World Congress on Infectious Diseases

June 24-26, 2024 | Paris, France

June 24 -26, 2024 | Paris, France
Infection 2024

Lata Kumari

Speaker at Infectious Diseases Conference - Lata Kumari
All India Institute of Medical Sciences, India
Title : Profiling of immune check point inhibitors (Tim-3, LAG-3, TIGIT, PD-1 and CTLA-4) in gallbladder cancer


Introduction: Gallbladder cancer is the 5th most common gastrointestinal cancer. Early diagnosis is not generally possible. The outlook is poor for recovery if the cancer is found after symptoms have started to occur, with a 5-year survival rate of close to 3%. The prognosis still remains poor. A number of therapeutic approaches, owing to the creation of advanced technological measures (e.g., next-generation sequencing, transcriptomics, proteomics), have been intensively innovated, including targeted therapy and immunotherapy. In the present study, we primarily focus on the targeted therapy capable of specifically inhibiting individual immune checkpoint inhibitors, e.g., Tim-3, LAG-3, TIGIT, PD-1, and CTLA-4 molecules that govern aberrant signaling cascades in GBC.

Methods: Only confirmed Gall bladder cancer patients were recruited in this study at the Department of Surgical Oncology/pathology, All India Institute of Medical Sciences (AIIMS), New Delhi. Both tissue and blood samples were taken from patients. Samples were processed accordingly for flow cytometric analysis. Flow cytometry was performed for Tim-3, LAG-3, TIGIT, PD-1, and CTLA-4 checkpoint inhibitor molecules.

Results: Expression of checkpoint inhibitory molecules differed between patients. Co-expression of TIGIT and PD-1 were found to be common in patients. A few patients also showed high co-expression of TIM-3 and PD-1. Only 2 patients showed a high expression profile for CTLA-4 and LAG-3.


Dr. Lata Kumari studied Biotechnology at Barkatullah University, Bhopal, India, and graduated with an MSc in 2006. She then joined Prof. S.S. Kanwar's research group at Himachal Pradesh University, Shimla, India. She received her PhD degree in 2013 at the same institution. After a three-year postdoctoral fellowship supervised by Dr Archana Singh at the Department of Biochemistry, AIIMS, New Delhi, she obtained the position of Scientist-II at the Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, New Delhi. She has published over 15 research articles in SCI(E) journals.