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8th Edition of World Congress on Infectious Diseases

June 09-11, 2025 | Rome, Italy

June 09 -11, 2025 | Rome, Italy
Infection 2023

Anticoronavirus formulations based on chitosan

Speaker at Infection Conference - Victoria Belen Ayala Pena
Departamento de Biología, Bioquímica y Farmacia-UNS, Argentina
Title : Anticoronavirus formulations based on chitosan

Abstract:

Our interdisciplinary working group was motivated by the challenge of proposing tools for the fight against the sudden pandemic caused by SARS-CoV-2 in 2020 and the present. We have obtained several formulations based on chitosan, a biodegradable, non-antigenic, non-toxic, and biocompatible natural polymer. These formulations have different characteristics and applications. We developed novel antiviral cotton fabrics impregnated with different formulations based on Chitosan, citric acid, and Cupper nanoparticles. The resulting impregnated textiles exhibited integrated properties of good adhesion without substantially modifying their appearance and anti-herpes virus and betacoronavirus efficacy (~ 100%), which enabling to serve as a scalable biocidal layer in protective types of equipment by providing contact killing against pathogens. The antiviral activity of formulations based on chitosan with copper nanoparticles was described for the first time in our work. This proposal may be considered a potential tool to inhibit the propagation and dissemination of enveloped viruses, including SARS-CoV-2. Another of the main current challenges is to optimize the use of personal protection elements without the detriment of biosecurity. For this proposal, we obtained sprayable formulations based on chitosan. It is known that the combination of both metals (copper and silver) enhances the antibacterial activity of each one individually. We obtained the first antiviral spray based on chitosan and both (silver and copper) nanoparticles. The spray has simplified production, with potential use in industry, it´s easy to use and apply, for domestic use, is biodegradable, has immediate antiviral action, has antibacterial, and it is non-toxic, and does not produce skin irritation. The spray is applicable to any type of woven or non-woven fabric, and plastic surfaces. Implementing this kind of sprayable product would allow the face masks to be reused without the need sterilization or their elimination after use. Therefore, the two major advantages attributable to Chitosan formulations are the prevention of the spread of viruses, including SARS-CoV-2. Secondly, these technologies will contribute significantly to the reduction of waste production.

Audience take away:
? The present work contributes to expanding knowledge in the development of antivirals applicable in materials.
? The audience will learn how certain antivirals can be applied on materials converting them into functionalized materials.
? This work will provide tools to develop antivirals applicable to surfaces for different types of viruses, the constant emerging and re-emerging viruses worldwide needs to be stopped with products that not only act on the patient but also prevent viral spread.

Biography:

Dr. Victoria Ayala studied Biochemistry at the Universidad Nacional del Sur (UNS), Bahía Blanca, Argentina, and graduated in 2008. She then joined the research group of Dr. Scolaro Luis at the Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina and in the Dr. Graciela Santillán group at UNS. She received her PhD degree in 2014 at the same institution. She is Assistant Professor at the UNS. She founded two laboratories of virology and is chief of one of them. She was twice awarded for her achievements in virology. Together with his work group obtained the patenting of an antiviral product. She has published more than 10 research articles in SCI(E) journals.

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