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6th Edition of World Congress on Infectious Diseases

June 24-26, 2024 | Paris, France

June 24 -26, 2024 | Paris, France
Infection 2023

Seki Masafumi

Speaker at Infection Conferences - Seki Masafumi
Saitama Medical University International Medical Center, Japan
Title : Comparisons of the molnupiravir, sotrovimab, and remdesivir use for COVID-19 patients in a tertiary hospital of Japan


New antiviral agents for COVID-19, including molnupiravir for the oral treatment and sotrovimab as the monoclonal antibody for the intravenous treatment are currently authorized and available in addition to remdesivir for the intravenous treatment in Japan.

We investigate the clinical use of molnupiravir, sotrovimab, and remdesivir for COVID-19 patients in our tertiary hospital from January to May 2022, which was the omicron strains dominant term.

35 COVID-19 patients received the molnupiravir administration orally. Among the 35 patients, 32 patients were used combined with intravenous administration of sotrovimab. The patients were 67.3 years old (26-90 y.o) and all survived. In the same term, the patients treated by either sotrovimab alone or sotrovimab plus remdesivir were either 14 cases of 79.0 (63-92) y.o. or 26 cases of 59.3 (36-97) y.o., respectively. Furthermore, the mild/moderate patients treated by molnupiravir were 15/20 cases although all patients with sotrovimab alone were mild, and the patients treated by sotrovimab plus remdesivir were 19 mild and 7 moderate, respectively. All patients treated by sotrovimab plus remdesivir were survived similar to the patients treated by molnupiravir, however, one patient treated by sotrovimab alone was died.

Most of the molnupiravir were used in the combination with sotrovimab. Molnupiravir may be useful for the COVID-19 patients who could accept oral administration of antiviral agents in the clinical setting.


Professor Seki has been graduated from Department of Medicine, Nagasaki University, as Medical Doctor, with the specialties including Internal Medicine, Infectious Diseases, and Infection Control. Later on he obtained his post-graduation, started working at Osaka University. After the professor of Tohoku Medical and Pharmaceutical University, presently he has been working at the Saitama Medical University Internatinal Medical Center, Hidaka City, Saitama, Japan.