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8th Edition of World Congress on Infectious Diseases

June 09-11, 2025 | Rome, Italy

June 09 -11, 2025 | Rome, Italy
Infection 2024

Acinetobacter baumannii blaOXA-143-like and blaOXA-72 with global international clone (IC) 2 and the Latin America endemic IC5 Exhibiting Strong Biofilm Formation in a Mexican Hospital

Speaker at Infection Conferences - Silvia Giono Cerezo
Instituto Politecnico Nacional, Mexico
Title : Acinetobacter baumannii blaOXA-143-like and blaOXA-72 with global international clone (IC) 2 and the Latin America endemic IC5 Exhibiting Strong Biofilm Formation in a Mexican Hospital

Abstract:

 Acinetobacter baumannii is an opportunistic pathogen responsible for healthcare-associated infections (HAIs) and outbreaks. Antimicrobial resistance mechanisms and virulence factors allow it to survive and spread in the hospital environment. However, the molecular mechanisms of these traits and their association with international clones are frequently unknown in low- and middle-income countries. Here, we analyze the phenotype and genotype of seventy-six HAIs and outbreak-causing A. baumannii isolates from a Mexican hospital over ten years, with special attention to the carbapenem resistome and biofilm formation. The isolates belonged to the global international clone (IC) 2 and the Latin America endemic IC5 and were predominantly extensively drug-resistant (XDR). Oxacillinases were identified as a common source of carbapenem resistance. We noted the presence of the blaOXA-143-like family (not previously described in Mexico), the blaOXA-72 and the blaOXA-398 found in both ICs. A low prevalence of efflux pump overexpression activity associated with carbapenem resistance was observed. Finally, strong biofilm formation was found, and significant biofilm-related genes were identified, including bfmRS, csuA/BABCDE, pgaABCD and ompA. This study provides a comprehensive profile of the carbapenem resistome of A. baumannii isolates belonging to the same pulse type, along with their significant biofilm formation capacity. Furthermore, it contributes to a better understanding of their role in the recurrence of infection and the endemicity of these isolates in a Mexican hospital

Biography:

Dr Silvia Giono Cerezo PHD  National School of Biological Sciences  Instituto politécnico Nacional -IPN- Chemist Bacteriologist Parasitologist Doctor of Science Member of the National Academy of Medicine Member of the Mexican Association of Infectious Diseases Collegiate Member of the Postgraduate Studies Professor of Medical Bacteriology and Host-Parasite Relationship Theory and laboratory also Problems of Medical Bacteriology Tutor, Director Advisor of Bachelor's, Master'sand Doctorate students Lines of research: Diagnostic Medical Microbiology and Antimicrobial Resistance of the ESKAPE group Diagnosis and analysis of the genome of Helicobacter pylori MLST of Stenotrophomonas spp  several publications.

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