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6th Edition of World Congress on Infectious Diseases

June 24-26, 2024 | Paris, France

June 24 -26, 2024 | Paris, France
Infection 2024

Nashwa Elsayed Elkasaby

Speaker at Infectious Diseases Conference - Nashwa Elsayed Elkasaby
Medical Microbiology and immunology Department, Faculty of medicine, Mansoura University, Egypt
Title : Viral pathogens of acute gastroenteritis in Egyptian children: Role of the parechovirus


Background and aim: Human parechovirus (HPeV) has emerged as a pathogen associated with acute gastroenteri? tis (AGE).

Aim: To detect the presence of HPeV in the stool samples from Egyptian children with AGE seeking care and the pos? sibility of its co?infection with other enteric viruses.

Methodology: One hundred stool samples were collected from children attending Mansoura University Children’s Hospital with AGE. HPeV and astrovirus were detected by reverse transcriptase?polymerase chain reaction (RT?PCR). At the same time, detection of rotavirus antigen and norovirus was achieved by enzyme?linked immunosorbent assay and rapid immunochromatographic method, respectively.

Results: The most frequently detected virus was rotavirus (39%), followed by norovirus (27%), HPeV (19%), and astrovirus (12%). Interestingly, the single infection with HPeV was 5%. Among the 19 HPeV positive samples, the co? infection of HPeV with other enteric viruses was detected in 9(43.9%) for rotavirus, 7(36.8%) for norovirus, 2(10.5%) for astrovirus, in 3(15.8%) for rotavirus and norovirus and 1(5.3%) for norovirus and astrovirus. Regarding the clinical presentation, there was no significant difference between children infected with HPeV alone and those infected with viruses other than HPeV alone; fever (p = 0.3), vomiting (p = 0.12), abdominal pain (p = 0.12), and grades of severity (P = 0.82). HPeV alone infected children were of mild severity (60%), and their main presenting symptom was fever (60%).

Conclusions: Detection of HPeV as a single viral pathogen in the stool of some children with AGE showed that this virus could be a causative agent of AGE in Egyptian children. Therefore, HPeV could be included as one of the viruses screened for AGE diagnosis in children in Egypt.


Dr. Nashwa Elkasaby, MSc, Ph.D is an associate professor of Medical Microbiology and immunology at the University of Mansoura. She received her, Ph.D. degree in Medical Microbiology with a specialization in Virology 2011 from Faculty of Medicine, Mansoura University, Egypt. She has an experience of more than 15 years in research and teaching and has collaborated with researchers from different countries. Alongside her academic work, Dr. Nashwa was an active member in Infection prevention and control Committee and Antibiotic Stewardship Programs in Mansoura university hospitals (Egypt) and Sohar hospital (Oman).