HYBRID EVENT: You can participate in person at Rome, Italy or Virtually from your home or work.

8th Edition of World Congress on Infectious Diseases

June 09-11, 2025 | Rome, Italy

June 09 -11, 2025 | Rome, Italy
Infection 2025

A single center retrospective study on the incidence and clinical outcomes of patients infected with Klebsiella Pneumoniae Carbapenemase (KPC)-producing klebsiella pneumoniae

Speaker at Kevin Cezar A. Estacio - Kevin Cezar A. Estacio
Dr. Paulino J. Garcia Memorial Research Medical Center, Philippines
Title : A single center retrospective study on the incidence and clinical outcomes of patients infected with Klebsiella Pneumoniae Carbapenemase (KPC)-producing klebsiella pneumoniae

Abstract:

Introduction:
Currently, one of the most significant nosocomial pathogens is Klebsiella pneumoniae strains that produce carbapenemase, in fact it is one of the most prevalent carbapenemase genes worldwide. Its rise also become a major global public health concern, and the best course of therapy is yet unknown.

Methodology:
This was a descriptive cross-sectional study which utilized retrospective chart review of patients who were admitted to a tertiary hospital for Klebsiella Pneumoniae Carbapenemase (KPC)-Producing Klebsiella Pneumoniae infection and treated with culture-guided antimicrobial agents between January 1, 2020 to August 31, 2023. Data on demographic profile, clinical and laboratory findings, and outcomes were collected and summarized.

Results:
A total of 88 patients were included with mean age of 53.4 years old and majority of patients were males (69.3%). The most common bacterial cultured site was respiratory (71.6%). The most common signs and symptoms were fever/chills (100.0%) and cough/colds (86.4%). In terms of antibiotic use, almost half had Cephalosporins (57.9%), Macrolides (54.5%), and Beta lactam + Beta lactamase inhibitor (54.5%). As high as 90.6% of patients had elevated WBC. The mean platelet count was 294.7, mean serum creatinine was 1.9, mean AST was 67.3 and mean ALT was 42.0. As much as 90.9% had abnormal Chest X-ray findings. In terms of antibiotic resistance, the highest prevalence was observed in Ampicillin + sulbactam (100% of 83 samples), Cefotaxime (100% of 54 samples), Ceftazidime (98.6% of 73 samples), Cefuroxime (97.6% of 85 samples), and Ceftriaxone (97.5% of 81 samples). The mean length of stay was 16.9 days and 80.7% had prolonged hospitalization. Mortality rate was 48.9%.

Conclusion:
Klebsiella Pneumoniae Carbapenemase (KPC)-Producing Klebsiella Pneumoniae was mostly seen in respiratory cultures. Patients with KPC-producing K. pneumoniae infection mostly had fever/chills and cough/colds. Almost all had elevated WBC and abnormal Chest X-ray findings. Antibiotic resistance was most prevalent in Ampicillin + sulbactam and Cefotaxime. Patients with this condition experience poor clinical outcomes with four-fifths experiencing prolonged hospitalization and half leading to mortality. Given the severity of this condition, strict infection control precautions should be observed and treatment should be guided by antibiotic sensitivity. 

Biography:

Dr. Kevin Cezar A. Estacio studied Medical Technology at the Far Eastern University- Manila and graduated in 2015. He continued his education and studied Doctor of Medicine at the Far Eastern University – Nicanor Reyes Memorial Foundation and graduated in 2019. He finished his residency training at the Department of Internal Medicine at the Dr. Paulino J. Garcia Memorial Research Medical Center in March 2024.

Watsapp