Title : Novel nanotechnology and its potential applications
Abstract:
Hydrophobic molecules with poor water solubility are often associated with low bioavailability. This physical property prevents these molecules from being developed for new drug use. Examples of these hydrophobic drug candidates include paclitaxel (Taxol), quercetin, cannabidiol (CBD), tetrahydrocannabinol (THC), retinoic acid, tocotrienols, and ivermectin. It is estimated that 70–90% of drug candidates under development stage are poorly soluble, which may be associated with low bioavailability, reduced therapeutic effects, and increased dosage that could cause unwanted adverse effects. In our previous work, we developed a novel Facilitated Self-assembling Technology (FAST for short) with several specific practical methods. The major advantage of this technology is that it is not engineered nor encapsulated, and is without lipid, surfactant, or metal component. The nanoparticles prepared using this technology are highly hydrophilic and stable. This nanotechnology would allow many drug candidates to be developed with increased solubility and bioavailability in their own nanoparticle form. The purpose of the current discussion focuses on the potential applications of EC16 (Epigallocatechin-3-Gallate-Palmitates, or EGCG-palmitates) nanoparticles that can be produced using three practical methods of FAST to prepare water-based nanosuspensions. The results demonstrate that this novel nanotechnology is able to generate stable and water-soluble nanoparticles with a wide range of applications. It could be used in new drug development or reformulate and improve the solubility and bioavailability of existing drugs.
