Title : Th1/Th2/Th17 cytokine profile among different stages of COVID-19 infection
Abstract:
Aim: to characterize Th1/Th2/Th17 cytokine profile (IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-?, and IL-17A) among different stages of COVID-19 infection.
Methods: This was a cross-sectional study which included 6 healthy individuals and 68 patients who were admitted with COVID-19 in the Department of Medicine, at All India Institute of Medical Sciences, New Delhi, from July 2020 to September 2020. Patients were categorized in to mild, moderate and severe COVID-19 groups and serum samples were drawn for the measurement of Th1/Th2/Th17 cytokines (IL-4, IL-6, IL-10, TNF-α, IFN-?, and IL-17A) which was done by BD™ Cytometric Bead Array.
Results: All the cytokines showed dynamic expression in the COVID-19 group, of which only IL-6 was statistically significant. Amongst the 3 severity groups of COVID-19, increased severity did not transform into increased cytokine level, with the exception for IL-6, which was statistically significant.
Conclusions: In our small sample study, 6 cytokines expressions were evaluated however most of them were elevated in COVID-19 patients but were not statistically significant except IL-6.
