Title : Antimicrobial agents based on natural compounds: The key to the solution of current crisis
Abstract:
Objective: Bacterial resistance to medicinal medications has indeed become a significant problem in recent decades. The rapid development of resistance mechanisms by bacteria has led to the loss of effectiveness of many commonly used antibiotics, posing a serious threat to global public health. Therefore we decide to consider antimicrobial agents based on natural compounds, as a key in solving the current crisis.
Materials and Methods: Natural products have commonly been found to possess antibiotic activity against panels of test organisms. These screening campaigns involve testing natural substances and extracts against various bacteria to identify potential antibacterial agents. We briefly reviewed the decision to look for antibacterial agents made from natural substances and extracts as a solution to the current situation.
Results: Many natural sources, such as antimicrobial peptides (AMPs),nanoparticles, enzyme disruption of the acylhomoserine lactones (AHLs), Mur enzymes, lysocine E, plant-derived natural products, polyphenols, nanozymes, antimicrobial peptidomimetic, antimicrobial of Fungi origin(penicillin, griseofulvin, amphotericin B, echinocandins, statins), produced a wide range of secondary metabolites that had the potential to exhibit antibacterial activity. Moreover, natural products often had complex chemical structures, which could provide multiple targets for bacterial inhibition or killing.
Conclusion: The exploration of natural products as a source of antibacterial agents is an ongoing and promising area of research. By leveraging the rich biodiversity of our natural world, we may find new solutions to combat antibiotic resistance and address the urgent need for effective antimicrobial treatments. This complexity may make it more difficult for bacteria to develop resistance compared to single-target antibiotics. Further research is necessary to isolate, identify, and characterize the active compounds, study their mechanisms of action, optimize their efficacy and safety, and evaluate their potential for clinical use.
