The BLUE-protocol is an ultrasound approach of lungs and veins, allowing with fine accuracies an immediate diagnosis of an acute respiratory failure among the six causes which regard 97% of patients seen in critical settings: hemodynamic pulmonary edema, pulmonary embolism, [....] » Read More
Purpose: In contemporary epochs, the prevalence of pertussis has been progressively on the rise, persisting as a formidable health concern. The manifestations following pertussis infection lean towards the atypical, making them easily disregarded or subject to misdiagnosis. Our a [....] » Read More
The increase in the transfer of pathogenic microorganisms between humans, livestock, wildlife and their environment observed in recent years, as well as the irrational use of antibiotics, makes it increasingly difficult to combat the growing multidrug resistance of bacteria such [....] » Read More
Background: Children with intestinal schistosomiasis are at risk for undernutrition, anemia, linear growth stunting, and impaired cognitive development. Vitamin A deficiency impairs immune function against parasitic pathogens. In rodents, dietary-induced vitamin A deficiency caus [....] » Read More
Nasogastric tube (NG tube) feeding in residential care homes for the elderly (RCHEs) carries the risk of contamination at the NG tube hub, a crucial connection point in the enteral feeding process. This contamination can lead to the spread of harmful microorganisms, potentially r [....] » Read More
At the onset of the COVID-19 Pandemic, policymakers and public health officials often cited “vaccine hesitancy” as a key challenge to reaching vulnerable populations, including immigrants, Spanish-speaking communities, Latino communities, and others who have been marg [....] » Read More
Successive sub-lineages of Omicron have spread since the occurrence of BA.1 in November 2021. Identified in July 2022, BQ.1 and BQ.1.1 expanded dramatically in Europe and North America. XBB and XBB.1 were first identified in India in mid-August 2022 and quickly spread to become p [....] » Read More
Background: • Sepsis is one of the most common leading causes of death in paediatric patients worldwide. • The WHO has defined sepsis as “a life-threatening organ dysfunction caused by a dysregulated host response to infection” • Early recognition of [....] » Read More
Kluyvera sp., an opportunistic Gram-negative bacillus found in clinical specimens such as sputum, urine, bile, peritoneal fluid, and blood, rarely causes significant infections. This case report manages a rare Kluyvera cryocrescens bacteremia in a female patient with chronic kidn [....] » Read More
This article aims to identify the impact of the novel coronavirus pandemic on malaria cases in the North, Northeast, Midwest, Southeast, and South regions of Brazil, given the similarity of initial symptoms, the need for reallocation of resources, and the burden on public health [....] » Read More
Introduction: A previously healthy and a fully vaccinated 5-year-old pre-schooler-aged male who presented to the ER with an insidious onset of decreasing level of consciousness and headaches before developing Status Epilepticus, and requiring admission to the PICU; with a final [....] » Read More
Background: The healthcare system in Bosnia and Herzegovina continues to face a significant burden due to the presence of chronic hepatitis C. Individuals who engage in the use of injectable drugs represent a substantial reservoir of the hepatitis C virus, hence presenting an end [....] » Read More
Introduction: Urethritis and cervicitis, in the majority of cases, are caused by sexually transmitted agents. They presents as discharge, pain, burning sensation but sometimes the patient may remain asymptomatic. Neisseria gonorrhoeae (Gono-coccal) and chlamydia trachomatis (Non- [....] » Read More
Leptospirosis is a zoonotic bacterial infection primarily caused by Leptospira species. This disease, characterized by a wide range of symptoms, is uncommon in the UK, with an incidence of 0.14 cases per 100,000. This oral presentation is the case of a 56-year-old male fish farme [....] » Read More
Bacteria of the Enterococcus genus are opportunistic microorganisms widely prevalent in the environment. An important source of pathogenic strains of Enterococcus spp. are farm animals and their living environment. Enterococcus faecium and Enterococcus faecalis species are most o [....] » Read More
COVID-19 type virus infection in a group of individuals results from the uptake by the lungs of these individuals of virions from the local atmosphere created by infected members of the group. The concentration of virions is determined by the social activity of group members and [....] » Read More
Adenovirus is a frequent cause of mild respiratory tract infection and gastroenteritis in children, it can cause severe respiratory illness in immunocompromised patients. Outbreaks and aggressive respiratory symptoms have been reported in military camps. Epidemics are well known [....] » Read More
The emergence of novel SARS-CoV-2 variants has raised concerns about the ability of COVID-19 vaccination programs to establish adequate herd immunity levels in the population. Adapted mRNA COVID-19 vaccines against BA.1 and BA.4-5 Omicron variants can provide a greater immunity a [....] » Read More
The aim of this study was to identify factors associated with non-adherence to tuberculosis (TB) preventive treatment among contacts with latent TB infection for new cases of pulmonary TB cases reported in Catalonia in 2019–2021. All contacts aged 18 years or older with a l [....] » Read More
The recent global outbreaks of infectious diseases such as SARS and COVID-19 have inflicted damage on both individuals and societies worldwide. To develop scientific strategies for prevention and precise treatment measures to counteract such outbreaks is imperative. After 28 year [....] » Read More
In recent years, there have been frequent outbreaks of infectious diseases such as SARS and COVID-19, which pose a significant threat to human life, health, and socio-economic development. Despite the lack of a specific medicine to combat virus infections, the medical community a [....] » Read More
Dengue is a mosquito-borne viral disease endemic in many countries particularly in the tropical and sub-tropical regions of the world. It is caused by one of the four serotypes of dengue virus (DENV). As the four serotypes are co-circulating, multiple encounters with heterologous [....] » Read More
The uroculturome indicates the profile of culturable microbes inhabiting urinary tract infections (UTIs). UTIs are often caused by opportunistic pathogens and it is necessary to do urine culture to find an effective antimicrobial to treat UTIs. This study targeted to understand t [....] » Read More
Although S. aureus UTI is known to be associated with other risk factors such as urinary catheterization, long hospital stay, or complicated UTI, our results show the community-acquired presentation of UTI. Trimethoprim-sulfamethoxazole may be used as an effective treatment for U [....] » Read More
Background: In response to the COVID-19 pandemic, innovative treatments and preventive measures continue to be pivotal. This interim analysis examines the use of AZD7442, a long-acting antibody (LAAB), as a pre-exposure prophylactic (PrEP) agent against the SARS-CoV-2 virus, aimi [....] » Read More
In 2016, according to the United States Centers for Disease Control and Prevention (CDC), and Public Health England, Candida auris, has been labeled as an emerging multidrug-resistant (MDR) yeast. Despite causing significant mortality, there are still no available Minimum inhibit [....] » Read More
Background: Periprosthetic joint infection (PJI) is the most common and feared arthroplasty complication. Ralstonia pickettii is an opportunistic Gram-negative bacterium, causing nosocomial infections in immunocompromised patients. It is an environmental bacterium that has been a [....] » Read More
Background: The rate of septic arthritis after arthroscopy ranges from 0.15% to 1%. Staphylococci are the leading causative organisms after knee arthroscopy whereas Cutibacterium acnes is often the causative organism after shoulder arthroscopy. Gram-negative bacillary infections [....] » Read More
Introduction: Severe acute respiratory syndrome coronavirus-2 virus (SARS-COV-2) was officially identified on January 2020 following investigations of pneumonia cases of unknown origin. Clinical presentation presents variations in symptom duration, severity, and complications. Am [....] » Read More
Introduction: Schistosomiasis is a parasitic infection endemic to Asia, Africa, and South America, and can be an unusual cause of pelvic pain in women. Due to similar symptoms with endometriosis, the diagnosis is often missed in regions of the world where Schistosomiasis is uncom [....] » Read More
Introduction: Mycobacterium shimoidei is a rare, slow-growing nontuberculous mycobacterium, first isolated in Japan in 1968. Only one case was reported in the United States, out of a total of fifteen cases reported worldwide. Due to its rarity and the current understanding o [....] » Read More
Background: Excessive and inappropriate use of antibiotics can lead to increased antibiotic-resistant strains of microorganisms. Actinomycetes, a versatile microbial group, are well known for producing important metabolites such as antibiotics, enzymes, herbicides, and anticancer [....] » Read More
Introduction: timely identification and treatment of trichosporonosis is important due to the severity of pathogenesis and different treatment from candidiasis and as a result of its high mortality. In this study, in addition to determining the abundance of this fungus in clinica [....] » Read More
A 59-year-old male with a history of relapsed refractory Chronic Lymphocytic Leukemia and associated hypogammaglobulinemia presented to our medical service with neutropenic fever, a skin lesion, and progressive pulmonary infiltrates. He had been evaluated for cough and neutrop [....] » Read More
REC-3964 is an oral, novel, diazepinedione-class chemical entity identified from Recursion’s high-content phenotypic imaging platform. REC-3964 inhibits toxins associated with Clostridioides difficile infection (CDI). In a disease-relevant hamster model of acute CDI, REC [....] » Read More
During this poster presentation, the presenter will discuss the development of the academic detailing (AD) DISH-AZ (Detailing for Improved Sexual Health in Arizona) program and will explain the methodological triangulation approach that is being used in Arizona. By employing a me [....] » Read More
Background: Human Immunodeficiency Virus (HIV) continues to be a major public health problem in the United States. Pre-exposure prophylaxis (PrEP) is highly effective in preventing HIV, but uptake remains low, especially among women. Furthermore, HIV prevention in pregnant indivi [....] » Read More
Alphaviruses, such as eastern equine encephalitis virus (EEEV), are genetically encoded by a single positive sense RNA genome. Following glycoprotein-assisted entry into the cells, fusion with the endosomal membrane, and capsid release, translation of the non-structural proteins [....] » Read More
Introduction: Facing the COVID-19 pandemic caused damage to the physical health of nurses, especially those who worked on the so-called front line, as they were exposed to constant risks of contamination, exhaustive workload and difficulties in the availability of inputs, such as [....] » Read More
Introduction: Long COVID comprises a complex, multidimensional, progressive and impactful syndrome characterized by the persistence of residual symptoms after the initial COVID-19 infection, without an alternative diagnosis or associated condition. Objective: To identify the p [....] » Read More
Background: Atlantibacter hermannii, previously known as Escherichia hermannii is a rare causative agent of human infections. Several reports testify that the most frequently infected patients are immunosuppressed, especially those undergoing hemodialysis. Materials and Method [....] » Read More
We describe a case of a 24-year-old male who presented with fever associated with flu-like symptoms that progressed to skin involvement with a diffuse erythematous and painful rash necessitating inpatient admission for further management. His physical examination was notable for [....] » Read More
Influenza B-associated rhabdomyolysis is relatively rare. Herein, we describe a retrospective case-series of five children hospitalized in a single institution for rhabdomyolysis from PCR-confirmed Influenza B. Viral sequencing revealed a novel deletion of one amino acid in the v [....] » Read More
Background: Necrotizing Enterocolitis (NEC), one of the most severe emergencies in neonates, is a multifactorial disease with diverse risk factors. Objectives: To compare between the clinical and laboratory characteristics of premature infants diagnosed with early-onset NEC (E [....] » Read More
Background: HIV drug resistance (HIVDR) remains a major threat to achieving sustainable viral suppression in patients on antiretroviral therapy (ART). In South Africa, since its rollout in December 2019, dolutegravir (DTG) has been the preferred ART backbone. Methods: We curat [....] » Read More
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can dysregulate host antiviral responses, including interferon production, to facilitate viral replication and spread via interacting with their hosts; however, the impact of the SARS-CoV-2 Omicron nucleocapsid protein [....] » Read More
The Cystic Echinococcosis in Peru, is an important problem in public health and in the economy, causing great economic losses both in livestock production and in the recovery of the health of the affected human population (Náquira C., 2010). Human Cystic Echinococcosis has [....] » Read More
Background: Hepatitis B virus (HBV) is associated with several acute and long-term complications and vaccination is the cornerstone of prevention. A recent outbreak in Gulu, Uganda, one of the districts covered by a mass vaccination campaign, suggests low uptake of HBV vacc [....] » Read More
Background: Hepatitis B virus vaccination plays a crucial role in preventing Hepatitis B infection, particularly in high-risk groups such as children under-five, who have a 60-90% higher chance of seroconversion. As per the World Health Organization (WHO), about 5–10% of in [....] » Read More
Background: Triple- or quadruple drug regimens (3 or 4DR) remain the gold standard for HIV treatment. However, there is currently a trend towards a reduction in the number of drugs from 3 or 4DR to double-drug regimens (2DR) based on Integrase Strand Transfer Inhibitors (INSTIs). [....] » Read More
Malaria is a public health problem and the cases diagnosed in the capital of Roraima have the potential to characterize the burden of the disease in the state. This study aimed to describe the epidemiological, clinical and laboratory aspects of malaria cases diagnosed in Boa Vist [....] » Read More
Background: The Philippines ranks fourth worldwide in tuberculosis incidence and is considered as a high-burden country of tuberculosis in the world. Differences in the pathophysiology and clinical presentation of TB in children make diagnosis more challenging than in adults.&nbs [....] » Read More
This case report describes a 57-year-old man with a history of coronary artery bypass grafting (CABG) and mitral valve replacement who presented with fever, rigors, and focal neurological symptoms. The patient was diagnosed with late-onset prosthetic valve endocarditis (PVE) comp [....] » Read More
Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019, the number of confirmed cases worldwide exceeded 770 million in 222 countries by March 2024, with more than 7 million confirmed deaths, according to the statistics from the World Health O [....] » Read More
Protoparvoviruses are a diverse genus of small, non-enveloped, single stranded DNA viruses in the Parvovirinae subfamily of the virus family Parvoviridae. Three of the fifteen member species of this genus have been associated with human infections, while some others infect domest [....] » Read More
Ticks play a significant role in disease transmission, rivaling mosquitoes in importance, yet knowledge gaps persist regarding ticks of public health importance. Their remarkable diversity stems from complex life cycles and interactions with hosts, leading to their ubiquity acros [....] » Read More
More than four years after the outbreak of the COVID-19 pandemic, the SARS-CoV-2 virus is still causing lasting damage around the world, impacting the health and lives of many. Preventive measures, such as widespread administration of vaccines, is playing a role in reducing the s [....] » Read More
Background: Cardiac aspergillosis is a rare form of Invasive Aspergillus infection that carries high mortality despite aggressive treatment. It usually occurs in patients with underlying cardiac abnormalities such as cardiac lesions, prosthetic valves, cardiac devices, and heart [....] » Read More
Uropathogenic Escherichia coli (UPECs) is the leading pathogen involved in urinary tract infection. Although quinolones are widely used in these cases, the resistance of UPECs to this class has been growing significantly, challenging the effectiveness of antibacterial therapy. Th [....] » Read More
Streptococcus Gordonii (SG) is an alpha hemolytic gram-positive streptococcus bacterium most commonly present in the oral cavity and gastrointestinal tract [1]. Despite an increase in the incidence of Infective Endocarditis, SG cases reported on a native aortic valve are relative [....] » Read More
Background: Awareness and uptake of HIV pre-exposure prophylaxis (PrEP) remains low among Black/African American cisgender women at risk for HIV acquisition. Primary care appointments present a valuable opportunity for introducing PrEP to clients; however, primary care providers [....] » Read More
A 56-year-old male with end-stage renal disease undergoing home peritoneal dialysis presented with abdominal pain, nausea, and altered mental status. White blood cell count was 12.3 10e3/uL, urinalysis was positive for 2+ blood, and peritoneal fluid contained a total nucleated ce [....] » Read More
A 4-day-old term infant with a low EOS risk score originally presented to the ED with six hours of lethargy and poor feeding. Initial work-up was demonstrated acute liver failure (PT/INR 18.5, ALT>90, AST>300), hypoglycemia, hyperferritinemia (ferritin >44,000), severe t [....] » Read More
Background: The World Health Organization (WHO) estimated the global incidence of syphilis among adults to be approximately 7.1 million in 2020. The following year, the American Centers for Disease Control and Prevention (CDC) reported a 32% increase in the incidence of primary/s [....] » Read More
We present a case of peritoneal coccidioidomycosis in an immunocompetent female patient initially diagnosed with tuberculosis at an outside hospital who presented with suspected RIPE therapy failure. She presented with a history of recurrent ascites, headaches, and shortness of b [....] » Read More
Background: Fever is the most commonly encountered issue in hospitalized patients. The most frequently used antipyretics to address fever are paracetamol and metamizole. The choice of drug administration route is considered to potentially reduce the treatment period, and also aff [....] » Read More
Introduction: This study focuses on the relationship between COVID-19 infection and myocarditis across different age groups. Previous studies have indicated that both natural Covid-19 infection and MRNACovid vaccination might trigger subsequent myocarditis especially in younger a [....] » Read More
Background and Goal: When bloodstream infection (BSI) is suspected, empirical broad-spectrum antimicrobial treatment (AMT) is immediately initiated after sampling for blood cultures. In the context of an increasing rate of multidrug-resistant organisms, rapid microbiological inve [....] » Read More
Bloodstream infections due to Gram-negative bacilli is a highly consequential nosocomial infection with serious consequences and even more so because the organisms are usually highly resistant to antimicrobials. The aims of this study were to describe incidence of bacteremia caus [....] » Read More
Background: The mortality of SARS-CoV-2 infection in non-vaccinated patients is still thought to be high despite the appearance of the omicron subvariant. A total of 36 adult, non-vaccinated patients who were hospitalized with SARS-CoV-2 infection during the omicron variant surge [....] » Read More
Background: Severe Acute Respiratory Syndrome (SARS) coronavirus 2 (SARS-CoV-2) is responsible for the 2019 coronavirus epidemic (COVID-19). SARS-CoV-2 infection is associated with high mortality and morbidity worldwide. A common sequela is chronic neurologic diseases, which seve [....] » Read More
Antibiotic resistance (AR) is both clinical and global public health concerns. In numerous countries, physicians have very few other options available to treat MDR and XDR infections. The World Health Organization (WHO) acknowledges AR is one of the top global public he [....] » Read More
While many advances in biological sciences have been applied in medicine, agriculture and industry with great benefit, some recent trends in society, governance structures and communications, appear to be hampering the use of new scientific findings for controlling infectious dis [....] » Read More
Pasteurella multocida is a gram-negative bacterium commonly found in the respiratory and gastrointestinal tracts of animals, such as cats, dogs and birds. This bacterium is known to cause a variety of infections in animals and can occasionally be transmitted to humans, resulting [....] » Read More
Lyme disease (Lyme borreliosis) is a multisystem zoonotic disease caused by the spirochete Borrelia burgdorferi. Individuals without treatment may progress to a disseminated stage having cardiac, neurological or another systemic manifestations. We present a rare case of a 40-year [....] » Read More
Introduction: Pyogenic ventriculitis is characterized by ependymal lining inflammation of the cerebral ventricular system and presence of suppurative fluid in the ventricles. Risk factors include a compromised immunity such as human immunodeficiency virus, diabetes, and cancer. T [....] » Read More
Leptospirosis is a zoonotic disease produced by spirochetes of Leptospira, with an incidence ten times higher in tropical regions like Puerto Rico, in comparison to the rest of the world. The principal reservoir are rats, dogs, cats and farm animals with excreted infected urine, [....] » Read More
Background: Trauma represents a significant public health issue in India, with substantial morbidity and mortality. Rapid access to appropriate care is essential for favorable post-injury outcomes. However, resource allocation strategies ensuring equitable access in developing na [....] » Read More
Monkeypox (Mpox) is an emerging viral zoonosis that has gained increasing attention due to its clinical similarity to smallpox and its ability to cause sporadic outbreaks in human communities. This condition, caused by the Monkeypox virus (MPXV), belonging to the Poxviridae famil [....] » Read More
The primary objective of this investigation is to estimate the population prevalence of SARS-CoV-2 antibodies, monitor the waning pattern of seroprevalence, and develop forthcoming vaccination strategies through a longitudinal study using a population-representative sample over t [....] » Read More
Background: Antimicrobial resistance (AMR) is a global public health concern that threatens the effectiveness of antibiotics and other antimicrobial drugs. As a result of drug resistance, antibiotics and other antimicrobial medicines become ineffective and infections become diffi [....] » Read More
Background: Globally, over 13 billion COVID-19 vaccine doses have been administered, which increases the risk of vaccine-related safety concerns. BNT162b2 and mRNA-1273 COVID-19 vaccines have been used for mass vaccinations in Curaçao, but information on adverse events (AE [....] » Read More
Background: Coronavirus disease (COVID-19) is an infectious disease with a heterogeneous clinical presentation caused by the novel coronavirus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The distinctive features of COVID-19 infection encompass a clinical sp [....] » Read More
Human Immunodeficiency Virus creates disruption in the lives of individuals, families, organisations, and communities at large. The introduction of the antiretroviral treatment brought hope but also brought challenges, especially around the issue of adherence which is important f [....] » Read More
Rabies is an acute viral disease that affects mammals, caused by an RNA virus belonging to the family Rhabdoviridae and the genus Lyssavirus. The disease is transmitted through bites or scratches from an infected animal. Rabies was one of the first infectious diseases to be scien [....] » Read More
Over the past few decades fungal infections have emerged as a constantly on the rise global health challenge, resulting in approximately 1.7 million deaths every year. Moreover, the long-term therapeutic application and prophylactic use of antifungal drugs in high-risk patients h [....] » Read More
Rabies is an acute viral disease with extremely high lethality, still causing approximately 59,000 human deaths worldwide every year. Despite being a disease studied for many years and having a very efficient prophylaxis, a high incidence rate is observed in developing countries. [....] » Read More
Context: Respiratory tract infections (RTIs) are one of the most common infectious diseases in children and represent a major cause of morbidity, hospital admission and mortality worldwide, with an estimated 3-5 million deaths per year. Although children are most at risk, adults [....] » Read More
Background: Urinary Tract Infection (UTI) due to Salmonella Typhi is uncommon, though there are scanty reports of bacteriuria caused by nontyphoidal Salmonellae and other gram negative bacilli. However, cases of bacteriuria with UTI due to nontyphoidal Salmonellae were more [....] » Read More
Introduction: A parasite may look docile and harmless but it can create havoc in human eyes. Early detection and timely treatment can prevent blindness. We report three cases of parasites in the eye with varying presentations. Case 1: A 76-year-old gentleman, a pet lover and a [....] » Read More
The activation of double stranded interference RNA occurring in the host cell is a natural phenomenon to control the over transcriptional effects of genes that could suppress the translational patterns. This genetic ability is currently being exploited in making the medicines to [....] » Read More
This contribution is an attempt to clarify some of the issues raised by the COVID-19 pandemic when it hit the globe roughly between 2020 and 2022 from the perspective of geopolitics. It is, therefore, per se, not a discussion from the narrow medical point of view but the politica [....] » Read More
Background: The Philippines, being a tropical country, makes for an interesting reservoir for diverse bacterial flora. One such pathogen is the Burkholderia pseudomallei, a Gram-negative pathogen, found in moist soil and rainwater. Cases increase during the monsoon rains, which o [....] » Read More
Background: While there is evidence that the burden of COVID-19 infection in hospitalized children is lesser than in their adult counterparts, currently, there are limited reports describing clinical data on COVID-19 patients particularly in pediatric population. Objective: To [....] » Read More
Fungal keratitis is one of the leading causes of blindness of infected corneal diseases, but the pathogenesis of fungal keratitis is not fully understood and therefore the treatment of the disease by medication is still under investigation. In the current study, we sought to stud [....] » Read More
The Acinetobacter baumannii group (AB-group), encompassing A. baumannii, A. pittii, A. nosocomialis, along with recent additions A. seifertii and A. dijkshoorniae, have emerged as prominent nosocomial pathogens with a global presence. Infections with antibiotic-resistant Acinetob [....] » Read More
Background: Histoplasmosis is an endemic mycosis that is usually asymptoma c but occasionally results in severe illness. While it is endemic in some regions of the world, including America, Africa, and parts of Asia, it is considered rare in India. Most pa ents who develop dissem [....] » Read More
Introduction: Stroke in a case of HIV, occurs by various mechanisms. The mechanisms include vasculi s secondary to opportunis c infec ons, HIV associated vasculopathy, cardioembolic stroke and HIV associated coagulopathy. Of these, the HIV associated vasculopathy is a diagnosis o [....] » Read More
Objective: Ebstein-Barr virus asymptomatically infects about 95% of adults worldwide. It is the main cause of infectious mononucleosis, which is observed most frequently in adolescents. Because EBV is an opportunistic virus, it is more difficult to diagnose. It is not the first f [....] » Read More
West Nile virus (WNV), classified under the Orthoflavivirus genus and Flaviviridae family, is a reemerging flavivirus perpetuated in an enzootic cycle between avian hosts and mosquito vectors. Periodic outbreaks of WNV in humans and horses can result in neuroinvasive disease and [....] » Read More
Background and aim: Human parechovirus (HPeV) has emerged as a pathogen associated with acute gastroenteri? tis (AGE). Aim: To detect the presence of HPeV in the stool samples from Egyptian children with AGE seeking care and the pos? sibility of its co?infection with other ent [....] » Read More
Introduction: Tuberculosis is chronic infection caused by mycobacterium tuberculosis and primarily attacks the lung. Tuberculosis of thyroid gland is an uncommon entity as the gland is resistant to infection due to bactericidal property of colloid high iodine content and extensiv [....] » Read More
Objective: Survival rate and quality of life of children with chronic hepatobiliary disease has improved since the development of liver transplantation. Incidence of bacterial infection is 36– 79% at 6 months post-transplantation and mortality of 3.0–10.6% at 3 months [....] » Read More
Background: As the world returns to pre-pandemic behavior patterns, surges in infections caused by antibiotic-resistant bacterial strains and seasonal viruses are a cause of serious concern. Persistent circulating infections exert socio-economic burdens on public health systems a [....] » Read More
Introduction: Measles virus is an aerosol borne and one of the most Contagious Pathogens1. Almost every measles virus Infection becomes Clinically manifest, furthermore, it can cause fatal complications and has high morbidity and mortality. Measles virus infection is a vaccine pr [....] » Read More
The Centers for Disease Control and Prevention recommends HIV screening for all patients ≥13 years. Parts of Metro Atlanta have HIV positive rates at 8-times the national average. Adolescents are the least likely group to know their HIV status and have the lowest rate of linka [....] » Read More
Lyme disease, the leading vector-borne illness in the United States, impacts roughly 476,000 individuals each year. As its geographical reach expands, healthcare providers face increasing hurdles in diagnosing and treating the disease, especially in its early stages. Despite bein [....] » Read More
Kaposi’s Sarcoma-associated herpes virus (KSHV), one of human gamma-herpesviruses, is a large double-stranded DNA virus that establishes long-term persistent infection. Primary infection of KSHV is usually asymptomatic, but its infection causes cancer under immunocompromise [....] » Read More
Syphilis is a venereal or vertically transmitted infectious disease caused by Treponema pallidum, a corkscrew shaped, motile spirochete. It generally progresses via stages and, if left untreated, can result in devastating cardiovascular and neurological sequelae. Ocular syphil [....] » Read More
During the initial outbreak of COVID-19, governments worldwide implemented various non-pharmaceutical interventions (NPIs) to help control the spread of the virus. Our study focused on assessing the impact of these interventions in the United States during the first wave of the p [....] » Read More
Background: There has been a global upsurge of oropharyngeal cancer (OPC) cases associated with increased human papillomavirus (HPV) infection. In Tanzania and Sub-Saharan African countries data on the same is lacking and HPV among OPC patients is not investigated routinely. The [....] » Read More
The aim of the study is the clinical evaluation of an diagnostic marker system that is able to distinguish between bacterial and viral infection, with focus on the influences on therapeutic regimes in primary care and inpatient care. Material and Method: The MeMed- BV® Sco [....] » Read More
Title : Will the Seine River water jeopardize the athletes' health during the sporting events of the 2024 Olympic Games in France
Claudia Ferreira, Biophytis Sorbonne, France
After describing the situation in which the athletes of the XXXIII Olympiad in France in 2024 from 26 July to 11 August, will find themselves namely, the city of Paris, the Seine River, the medical infrastructure, the past experience with SARS, and giving data on hygiene, pathoge [....] » Read More
Title : Assay identifies rVSV?G-ZEBOV-GP vaccination status and correlates Ebola virus glycoprotein with vesicular stomatitis Indiana virus nucleoprotein antibodies
Prabha Chandrasekaran, NIAID, National Institutes of Health, United States
In the absence of well-defined correlates of protection, the quantity and duration of the main vaccine-antigen-induced immunoglobulin G (IgG) antibodies are often used as proxy indicators of vaccine efficacy; IgG responses to vaccine vector antigens are less well-characterized. H [....] » Read More
Title : Efficacy of oral 20-hydroxyecdysone (BIO101) in adults with severe COVID-19 (COVA): A randomized, placebo-controlled, phase 2/3 trial
Valerie Pourcher, Pitie Salepetriere Hospital, France
Background: SARS-CoV-2 infects human cells through interaction between its spike protein, and ACE2, a key element of the RAS. Thus SARS-CoV-2 may induce an imbalance of the RAS leading, among other symptoms, to severe pneumonia associated with COVID-19. We h [....] » Read More
Title : Factors affecting the outcomes of patients with coronavirus disease (COVID-19) admitted in a tertiary hospital in Iloilo City: A retrospective cross-sectional study
Petersian M. Alcazaren, West Visayas State University Medical Center, Philippines
Background: COVID-19 is a viral respiratory illness caused by SARS-CoV-2, confirmed with RTPCR testing. Considering the heterogeneity of clinical picture of COVID-19 disease, and the threats of its variants, the review of current clinical data and outcome of available management [....] » Read More
Title : SHIVER: A Syphilis/HIV ‘Test and Treat’ POCT intervention trial to reach rural/remote and underserved populations in Saskatchewan, Canada
Cara Spence, University of Saskatchewan, Canada
Context: An alarming increase of infectious and congenital syphilis rates is being seen in Saskatchewan and the prairie provinces of Canada. According to the Public Health Agency of Canada, the national rate of infectious syphilis increased from 5.1 per 100,000 population in 2011 [....] » Read More
Title : An iPSC-derived organoid-based model of intestinal filovirus infection
Elizabeth Yvonne Flores, Boston University School of Medicine, United States
Affected Ebola virus disease (EVD) patients lose copious amounts of fluids in a matter of days, rapidly deteriorating into hypovolemic shock and death. Similar intestinal manifestations were also reported for Marburg virus (MARV) disease, another filovirus. At present, available [....] » Read More
Title : Hemophagocytic lymphohistiocytosis syndrome and syndrome of inappropriate antidiuretic hormone ADH release: keep in mind visceral leishmaniasis. Case report and literature review
Daniela Tirotta, Morgagni - Pierantoni Hospital in Forlì, Italy
Introduction. Visceral leishmaniasis is an potentially fatal and neglected tropical disease, according to the World Health Organization’s : mortality is still very high ( 95% ) when untreated. This disease presents a broad spectrum of symptoms (oligosymptomatic infection, b [....] » Read More
Title : Foreign fungus: Candida duobushaemulonii bloodstream infection in an immunocompromised host at Baguio General Hospital & Medical Center: A case report
Hideliz Marie G Pascua, Baguio General Hospital and Medical Center, Philippines
Candida duobushaemulonii is a yeast that belongs to the Candida haemulonii species complex. Similar to Candida auris which is an emerging global health threat, C. duobushaemulonii is a major concern in the healthcare system as it is often multidrug resistant. Prese [....] » Read More
Title : Implementing the Covid-19 vaccination programme in the Southwest of England: Lessons from a normalisation process theory perspective
Anne Morris, North Bristol NHS Trust, United Kingdom
Background: Vaccination remains one of the most successful public health interventions in preventing severe disease and death. The roll-out of Covid-19 vaccination programmes has helped protect billions of people around the world against Covid-19. Most of these programmes have be [....] » Read More
Title : A case report of a 22 year old male diagnosed with SLE, with concomitant infections of COVID 19 moderate disease and HIV-AIDS
Petersian M. Alcazaren, West Visayas State University Medical Center, Philippines
Background As the world presently navigates the coronavirus disease 2019 (COVID-19) pandemic, there is a growing need to assess its impact in patients with underlying immunocompromised states, including autoimmune rheumatic diseases, such as systemic lupus erythematosus (SLE), an [....] » Read More
Title : An unusual case of multidrug-resistant klebsiella pneumoniae and vancomycin-resistant enterococcus faecium skin and soft tissue infection in an immunocompromised host
Ashley Zhou, Mayo Clinic, United States
Skin and soft tissue infections (SSTI) represent an uncommon source of infection (<10%) in patients with persistent or recurring fever and neutropenia.1-3 Worldwide, the prevalence of immunocompromised hosts is increasing even as the incidence of gram-negative and of multidrug [....] » Read More
Title : Clinical characteristics and outcomes of breakthrough COVID 19 infection among vaccinated patients admitted in a tertiary hospital
Nadine Bacalangco Suerte, West Visayas State University Medical Center, Philippines
Background: Vaccination across countries against COVID-19 have shown to be effective against infection and mortality in different settings. However, recent data describe breakthrough COVID-19 infection among vaccinated individuals. Risk factors and clinical characteristics have b [....] » Read More
Title : Acinetobacter baumannii blaOXA-143-like and blaOXA-72 with global international clone (IC) 2 and the Latin America endemic IC5 Exhibiting Strong Biofilm Formation in a Mexican Hospital
Silvia Giono Cerezo, Instituto Politecnico Nacional, Mexico
Acinetobacter baumannii is an opportunistic pathogen responsible for healthcare-associated infections (HAIs) and outbreaks. Antimicrobial resistance mechanisms and virulence factors allow it to survive and spread in the hospital environment. However, the molecular mechanism [....] » Read More
Title : Treatment of iron-deficiency anemia reduces pneumonia- and bacteremia-associated hospitalizations
Eric Brownhill, Jacobi Medical Center, United States
Intro: The safety profile of oral iron supplementation is well established and generally benign, but many practitioners limit iron supplementation in patients hospitalized for infectious causes, even in the presence of iron-deficiency anemia (IDA). Nearly all human pathogens requ [....] » Read More
Title : Use of intravenous immunoglobulin in neonatal enteroviral sepsis
Michele de Leon Jauregui, University of Utah, United States
A 4-day-old term infant with a low EOS risk score originally presented to the ED with six hours of lethargy and poor feeding. Initial work-up was demonstrated acute liver failure (PT/INR 18.5, ALT>90, AST>300), hypoglycemia, hyperferritinemia (ferritin >44,000), severe t [....] » Read More
Title : Low-volume direct multiplex PCR for etiological diagnosis of infectious uveitis
Eduardo Ferracioli Oda, University of Sao Paulo, Brazil
Purpose: To describe the pathogens detected in intraocular fluid of individuals with active uveitis using a low-volume direct multiplex PCR. Methods: Eighty-six individuals with active uveitis were included in this study between July, 21 and November, 23. All participants had [....] » Read More
Title : Patterns of chlamydia trachomatis and neisseria gonorrhoeae in different anatomical sites among pre-exposure prophylaxis (prpe) users in Brazil
Renata Karina Reis, University of Sao Paulo, Ribeirao Preto College of Nursing, Brazil
Introduction: The presence of an untreated STI significantly increases the chance of acquiring HIV. In Brazil, CT/NG testing among PrEP users is insufficient and syndromic treatment is a priority in clinical practice. Multi-site testing for CT/NG improves screening of asymptomati [....] » Read More
Title : Predictors of vaccination rates in people living with HIV/AIDS followed at a specialty care Clinic Ribeirao Preto, Sao Paulo, Brazil
Renata Karina Reis, University of Sao Paulo, Ribeirao Preto College of Nursing, Brazil
Introduction: Vaccine hesitancy was considered by the World Health Organization as one of the 10 threats to global public health in 2019. In Brazil, the National Immunization Program offers the population vaccines free of charge through the Unified Health System. However, people [....] » Read More
Title : Epidemiological and clinical features of COVID-19 among the pediatric patients admitted in the Zamboanga City Medical Center and other facilities handling COVID patients
Kristine Mae D. Barredo, Zamboanga City Medical Center, Philippines
Introduction: Defining the epidemiological and clinical features of COVID in pediatric patients can aid in the control of spread and improve the curative rate. Objectives: This study determined the epidemiological and clinical characteristics of COVID confirmed children admitt [....] » Read More
Title : HAV-ing a Moment
Dorarca Lynch, Galway University Hospital, Ireland
Clinical case: We present a case of a 32-year-old Indian gentleman admitted to a tertiary hospital in the West of Ireland Hospital with a weeklong history of fevers and right upper quadrant pain complicated by the development of clinical jaundice. His past medical history w [....] » Read More
Title : Stability and disinfection studies for risk group 4 pathogens: Improving biosafety measures for laboratories and patient management
Joo Hee Waelzlein, Robert Koch-Institute, Germany
Our project highlights the critical need for scientific data in assessing the risks posed by emerging and re-emerging viruses, both during endemic and pandemic outbreaks. It emphasizes the importance of validated decontamination procedures and infection control measures with the [....] » Read More
Title : Establishment of a human lung organoid method platform for infectious disease modelling
Joo Hee Waelzlein, Robert Koch-Institute, Germany
Background: In recent years, organoids have advanced to prominent and versatile tools in 3R research, representing valuable alternatives for animal models and physiologically relevant human disease models at the same time. As the federal Public Health Institute, the RKI aims to e [....] » Read More
Title : Diagnosis of neonatal sepsis using a rapid lateral flow test to detect serum amyloid A.
Julia Nowak, Maynooth University, Ireland
Sepsis is a serious medical condition, and newborns in low- and middle-income countries (LMICs) are particularly vulnerable. Uganda has one of the highest rates of neonatal sepsis deaths in the world at 17 neonatal deaths per day. Such high mortality rates are largely due to the [....] » Read More
Title : Multi-omics workflow for the identification of discriminant markers associated with Trypanosoma cruzi populations
Amy Hesketh, Bioaster, France
Introduction: Trypanosoma cruzi (T. cruzi) is a protozoan parasite that causes Chagas disease. This zoonotic disease is transmitted to human by blood-sucking triatomine bugs. According to WHO, Chagas disease is affecting 30 000 new cases and is causing 13 000 deaths per year main [....] » Read More
Title : Acute HIV infection presenting as eczema herpeticum and herpes simplex keratitis: A case report
Alvaro J. Vivas Salinas, Clínica Central del Quindío, Colombia
Introduction: Eczema herpeticum (EH), also known as Kaposi’s varicelliform eruption, is an unusual, severe manifestation of herpes simplex infection. It usually presents in pediatric patients with history of atopic dermatitis. It can be a life-threatening disease with morta [....] » Read More
Title : Disseminated echinococcus infection with cardiopulmonary involvement
Reem Abdulla AlSaadi, Cleveland Clinic Abu Dhabi, United Arab Emirates
Our presentation is about a challenging case of a 28-year-old male, previously healthy and a nonsmoker, from India and working as a security guard. He was referred to our facility for evaluation of disseminated Echinococcus infection affecting the lung and heart, presenting with [....] » Read More
Title : Prevalence of co-infections among hospitalized patients with COVID-19 at a tertiary-care Hospital, Muscat, Oman: A retrospective study
Khalid Muneer Albalushi, Sultan Qaboos University, Oman
Objectives and rationale: This study aims to investigate the prevalence, demographics, and risks of co-infections among hospitalized patients at Sultan Qaboos University Hospital (SQUH); a tertiary-care hospital in Muscat, Oman. Aim: This study aims to identify the most common [....] » Read More
Title : Colonization and infection in admitted patients with vancomycin-resistant enterococcus in a tertiary hospital
Hatice Turk Dagi, Selcuk University, Turkey
Enterococci are gram-positive, facultative anareobic bacteria that are usually found in gastrointestinal tract of humans, animals and environmental sources. Enterococci can lead to severe hospital-acquired infections and are difficult to treat due to their high level of antibioti [....] » Read More