Diseases and your body's response to those infections are referred to as sepsis and septicemia in healthcare. Both terms come from the Greek word sepsis, which literally means "to putrefy" or "to render rotten." Although the terms sepsis and septicemia are sometimes used interchangeably, they are not interchangeable because their definitions differ. Septicaemia is when microorganisms enter the bloodstream, they produce blood poisoning, which leads to sepsis. Sepsis is a life-threatening infection reaction that can result in tissue damage, organ failure, and death. Sepsis is an infection-induced inflammatory response that is severe. When your body is threatened by a serious infection, your immune system sends out chemical messengers to signal that something is wrong. Inflammation is caused by these chemical messengers all across the body.