The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious RNA virus that was first identified in December 2019 in Wuhan, China. It is the pathogen responsible for the present coronavirus disease 2019 (COVID-19) pandemic. A large number of genetic var [....] » Read More
RNA viruses are a major threat to the human health. They are responsible for infections with high morbidity and mortality rates and an extraordinary socioeconomic burden. In the last decades, different RNA viruses have produced major outbreaks against which there were no efficien [....] » Read More
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Infectious diseases are becoming a health burden, causing numerous hospitalisation cases and deaths and leading to global economic losses. The prevention and control of infectious diseases have become more important as a result of the COVID-19 pandemic. Traditional disinfection m [....] » Read More
Background: New antiviral agents for COVID-19, including molnupiravir for the oral treatment and sotrovimab as the monoclonal antibody for the intravenous treatment are currently authorized and available in addition to remdesivir for the intravenous treatment in Japan. Method [....] » Read More
Neonatal microcephaly and adult Guillain-Barré syndrome are severe complications of Zika virus (ZIKV) infection. The robustly induced inflammatory cytokine expressions in ZIKV-infected patients may constitute a hallmark for severe disease. One of them is the high mobility [....] » Read More
Polymicrobial biofilms are associated with a wide range of infections, present in medical devices such as catheters and joint prostheses, valves, and in chronic tissue infections, which occur mainly in patients with cystic fibrosis, and oral infections, among others, as well as o [....] » Read More
In order to contribute to the understanding of the mechanism of invasion of epithelial cells by Shigella sp., we have first shown (i) Shigella strains as well as clinical or environmental strains are able to secrete biosurfactant-like molecules (BLM) directly [....] » Read More
With all the advances in medicine and medical treatments, MDR bacteria remains one of the greatest threats in healthcare systems. The rates of AMR (antimicrobial resistance) organisms continues to increase globally despite the efforts to combat. WHO has declared that AMR is one o [....] » Read More
With the presence of COVID-19 vaccines, the prevalence of new COVID-19 strains is decreasing dramatically. In the meantime, many vaccines were produced, Despite the beneficial effects of the COVID-19 vaccines, their side effects have also been revealed recently. One of the side e [....] » Read More
Background and Purpose: Rabies virus is a fatal infectious disease in the mammalian host including humans, carnivores, and livestock which imposes a huge burden on the health of the community and the global economy. The development of new rabies vaccines is a criti [....] » Read More
INTRODUCTION: Worldwide, one in eight deaths is due to cancer. Projections based on the GLOBOCAN 2012 estimates predict a substantive increase new cancer cases per year by 2035 in developing countries if preventive measures are not widely applied. According to the World Health Or [....] » Read More
Background: Multiple therapeutic agents have been demonstrated to provide benefits against COVID-19. Clinical trials which evaluated remdesivir for SARS-CoV-2 infection had shown efficacy in disease recovery and mortality and it is of equal importance to determine the onset of tr [....] » Read More
Introduction: The SARS-CoV-2 virus, the main causative agent of COVID 19 infection was first detected in the province of Hubei in Wuhan China in December of 2019 and has overwhelmed the capacity of the government and hospitals to provide healthcare services to cater to the growin [....] » Read More
Background: The initiation of anti-retroviral therapy (ART) effectively restores immune function and reduces HIV-related morbidity and mortality. However, virologic failure while on ART may lead to increased morbidity and compromised quality of life. The aim of this study was to [....] » Read More
Pulmonary tuberculosis is a worldwide global health burden. According to the WHO guidelines on tuberculosis infection prevention and control that was updated last 2019, tuberculosis accounts for more than 10million cases per year and the deaths caused by Tuberculosis alone accoun [....] » Read More
Introduction: Chromoblastomycosis is a chronic subcutaneous fungal infection characterized by the presence of muriform cells commonly diagnosed among countries in tropical and subtropical regions like Africa, Latin America, India, China, Japan, Malaysia and Austral [....] » Read More
Introduction: Dengue fever is a significant cause of morbidity throughout the world caused by the dengue virus (DENV). Four antigenically different dengue virus serotypes (DENV-1,2,3, and 4) are known to cause infections in humans (Halsey,2012). Chances for developing dengue hem [....] » Read More
Background: Multisystem Inflammatory Syndrome (MIS) is a rare form of COVID-19 affecting multiple extrapulmonary organ systems without severe respiratory illness. It is primarily seen in children under 21 years of age but with similar but rare syndrome in adults that may require [....] » Read More
Introduction: The main causative agent of Tetanus infection is the bacterium Clostridium tetani, a gram-positive, spore-former obligate anaerobic microorganism. It continues to be an important public health concern in developing countries like the Philippines, even though it is p [....] » Read More
Background: Mortality of tetanus infection is directly proportional to the severity of infection. Tetanus is a preventable yet very fatal disease due to its autonomic dysfunction, muscle spasms, and rigidity. Aggressive intervention is necessary in order to manage the Tetanus in [....] » Read More
Diseases of microbial aetiology of economic significance have surfaced in the aquaculture sector leading to high mortality and economic losses for farmers. Various environmentfriendly remedial measures have been taken up as an alternative to antibiotics to control microbial disea [....] » Read More
Short Introduction: Drug repurposing is an alternative avenue for identifying new drugs to treat tuberculosis (TB). Although TB can be cured with anti-tubercular drugs, the emergence of multidrug-resistant and extensively drug-resistant strains of Mycobacterium tuberculos [....] » Read More
BACKGROUND AND AIM: Tuberculosis is known to mimic several condition, especially malignancy. Pulmonary TB can present with pulmonary infiltration with or without mediastinal lymphadenopathy. TB often gets misdiagnosed in the countries having low incidence of TB with high incidenc [....] » Read More
The last 2 years after breakout of Covid pandemic there have been reported and published skin integrity complications mostly in critical care departments covid infected patients. International literature highlights the spread per 57% of facial pressure ulcer development, as conse [....] » Read More
Aim of study: Group B streptococcus (GBS) is a leading cause of invasive infection among neonates and infants worldwide, with two described syndromes, early onset GBS (EOGBS) disease and late onset GBS (LOGBS) disease. In our study, we investigated the incidence of invasive GBS [....] » Read More
Background: Even though respiratory viruses are one of the most common triggers for asthma exacerbations, not all of these viruses affect patients equally. Objective: To assess the prevalence of covid19 infection in patients presented with acute exacerbation of asthma, C [....] » Read More
Background: Nigeria accounts for 25% of Neglected Tropical Disease (NTDs) burden. The disease tends to impact negatively on wellbeing and productivity. Efforts via health expenditure for NTDs programme have not improved health outcomes. The study examines long-run relationship b [....] » Read More
Background: Contact tracing (CT) can support Ebola Virus Disease (EVD) outbreak control, but its effectiveness depends on rapid identification and regular, close monitoring of contacts. Ideally, all new cases should be previously-known contacts and spend minimal time ill in the c [....] » Read More
Background: Insects always play an important role in the global ecosystem. Several hypotheses and studies were conducted emphasizing their role in transmitting or spreading the virus in the environment. Among insects, flies are the most common and anthropophilic insects in the w [....] » Read More
Background: Intracranial aneurysms (IAs) are more prevalent in women than men and aneurysmal subarachnoid hemorrhage disproportionately affects postmenopausal women. These sex differences suggest estrogen protects against IA progression that can lead to rupture, but the unde [....] » Read More
Severe pneumonia is one of the most common causes of sepsis and respiratory failure requiring intensive care. Despite advances in diagnostic techniques, antimicrobial therapy, respiratory support and organ support modalities; mortality and morbidity of severe pneumonia remain sig [....] » Read More
The objective of the present research consisted in demonstrating the potentialities and real capacity of application of the methodology of the Regressive Objective Regression (ROR) in the different fields and branches of scientific research. The results obtained were possible, th [....] » Read More
Vancomycin has been in clinical use for more than 50 years. It is a highly effective antimicrobial agent against gram positive organisms including methicillin-resistant Staphylococcus aureus and Enterococci spp. However, there are practical challenges in the use of vancomycin inc [....] » Read More
Since their development, vaccines have dramatically reduced the burden of numerous infectious diseases, promoting individual and social growth, prosperity and wellbeing across the globe. In the coming decade, vaccines are projected to save the lives of twentyfive million people, [....] » Read More
Background: Chronic osteomyelitis is notoriously difficult to eradicate with multiple clinical failures and relapses after periods of quiescence and apparently successful treatment. The fact that certain bacteria form biofilm with metabolically inactive colonies contributes to [....] » Read More
Toll-like receptors are essential components of innate immunity that serve as the first line of defence against invaded microorganisms. However, successful infectious pathogens subvert TLR signalling to suppress the activation of innate and adaptive responses. Brucella species ar [....] » Read More
Hepatitis B (HBV) and C (HCV) are two among other forms of infections for which co-infection in HIV has been associated with alteration of the immune response, increased risk of progression to liver diseases and increased risk of hepatotoxicity associated to antiretroviral [....] » Read More
Avian influenza (AI), commonly known as bird flu, is caused by influenza A viruses (IAV) that circulate in humans, horses, dogs, swine, and birds [1]. AI has captured the attention of international and local communities over the years due to its devastating consequences to the he [....] » Read More
Background: Cutaneous leishmaniasis (CL) is endemic in many regions of the world, and has a significant economic and health impacts. Despite the numerous proposed therapies for this zoonotic parasitic disease. Currently, there is no definitive cure for CL. Meglumine antimony comp [....] » Read More
Introduction: Coronavirus disease 2019 (COVID-19) is an emerging respiratory infections and is known to cause illness ranging from the common cold to severe acute respiratory syndrome. At present, the disease has been posing a serious threat to the communities, and it is critical [....] » Read More
Hepatitis is an infectious liver disease caused by the Hepatitis B virus. The Hepatitis B virus can remain in the body after infection during pregnancy, vertically transmit to the foetus, and cause chronic liver damage. Regarding this, immunization during pregnancy stops this ver [....] » Read More
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Gram negative bacteria (GNB) are the most common cause of healthcare-associated bacteraemias, most commonly caused by Escherichia coli, Klebsiella and Pseudomonas. GNB carry significant mortality and morbidity, therefore prompt and appropriate antibiotic therapy is important. How [....] » Read More
Background: Hospital Acquired Pneumonia is an important public health concern. Even with the advent of new anti-bacterials, there is an increasing prevalence of anti-microbial resistance worldwide. In particular, Ventilator Acquired Pneumonia can increase mortality risk in patie [....] » Read More
Background In December 2019, the coronavirus disease 2019 (COVID-19) first became identified in the market places of Wuhan, China. The first incidence of COVID-19 was identified in Saudi Arabia on March 2, 2020, and then within a month, the total number of reported instances ha [....] » Read More
Background and objective: Mesenchymal stem cells (MSC) can alleviate the damage of structure and function of pulmonary vascular endothelial cells (VEC). But therapeutic effects of MSC are different among sepsis-induced acute respiratory distress syndrome (ARDS) patients. MicroRNA [....] » Read More
Introduction: Tularemia is an uncommon disease. An average of 173 cases per year were reported in the US for the past 20 years.(1) A low minimal-infective-dose, high rate of dissemination and the possible mortality make tularemia a potential weapon for bioterrorism.(2) This repo [....] » Read More
BACKGROUND: Nasal cavity tuberculosis is rare, but it can be caused by either a pulmonary disease or retrograde involvement of the nose by lupus vulgaris of the facial skin. Here we are going to present a rare case of nasal cavity tuberculosis. PRESENTATION AND MANAGE [....] » Read More
Background. The novel coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2 is severe and involves multiple organs in approximately 5%-10% of patients, leading to multi-organ dysfunction and failure. Methods. Necropsy tissues (lungs, heart, liver, kidney, small-intestine) we [....] » Read More
Purpose: To evaluate the value of modified Brixia scoring system in predicting mortality in hospitalized COVID-19 patients. Methods and materials: An observational retrospective pilot study included 292 patients (178 male and 114 female) with PCR-confirmed COVID-19 infection h [....] » Read More
Nowadays, the rapid expansion of dengue fever vectors, Aedes albopictus and Ae.aegypti, around the globe has been warned by various documents. In recent years, the eastern neighbor of Iran, Pakistan, has been involved with dengue outbreaks, and the risk of the entrance of t [....] » Read More
Introduction: Protozoa are unicellular and eukaryotic microorganisms. Despite the simple cellular structure, they can destroy the host’s body during its parasitic life, especially when this life contains symbiosis with one or more other microorganisms. Protozoa have receive [....] » Read More
Background: Periprosthetic joint infection (PJI) is the most common and feared arthroplasty complication. Ralstonia pickettii is an opportunistic Gram-negative bacterium, causing nosocomial infections in immunocompromised patients. It is an environmental bacterium that has been [....] » Read More
PURPOSE: Multisystem Inflammatory Syndrome (MIS) is a severe inflammatory response, that occurs days to weeks following the infection of SARS-CoV2, the virus responsible for COVID -19. Initially known in children and named MIS-C, recently several cases of MIS in adults have bee [....] » Read More
Title : Novel nasal formulations containing EC16 to combat long COVID
Stephen Hsu, Augusta University, United States
Background: Severe Acute Respiratory Syndrome (SARS) coronavirus 2 (SARS-CoV-2) is responsible for the 2019 coronavirus epidemic (COVID-19). SARS-CoV-2 infection is associated with high mortality and morbidity worldwide. By Dec 1, 2022, over 643 million cases have been reported w [....] » Read More
Title : MVA-based virotherapies in the treatment of infectious diseases
Inchauspe Genevieve, ImmunResQ Department, Transgene, France
A famous milestone in the vaccine field has been the first successful vaccination against smallpox in 1798 by Edward Jenner. Using the vaccinia cowpox virus, Jenner was able to protect vaccinees from variola or smallpox. The Modified Virus Ankara (MVA) poxvirus strain has been on [....] » Read More
Title : Insecticide resistance and use of household insecticides for personal protection: Insights from vector-borne disease outbreaks
Walter Fabricio Silva Martins, LSTM, United Kingdom
Aedes aegypti is the most important vector of at least four fatal and/or debilitating arboviruses (dengue, chikungunya, yellow fever and Zika). Insecticide-based approaches remain the major intervention to minimize vector-borne disease burden across the diseases. In Brazil [....] » Read More
Title : Evaluating the effectiveness of antimicrobial stewardship on escherichia coli resistance in patients with urinary tract infection
Paulo Arroyo, Warwick Medical School, United Kingdom
Objectives: Although several studies have shown that the application of antimicrobial stewardship (AMS) has a positive impact on reduction of antimicrobial resistance and therefore the clinical outcomes of patients, most of the studies were conducted some years ago, and [....] » Read More
Title : Pandemic response: New models for drug discovery
Giancarlo Biagini, Liverpool School of Tropical Medicine, United Kingdom
Soon after SARS-CoV-2 was recognised as a pandemic threat, we set out to pioneer technologies to fast-track and de-risk advanced drug development. Our highly innovative models offers industry access to pioneering technologies which support the development of game-changing nove [....] » Read More
Title : Rapid, isothermal detection of Zika virus: a potential alternative to RT-PCR
Rickyle Christopher Balea, The University of the Sunshine Coast, Australia
Zika virus (ZIKV) is a re-emerging flavivirus that poses a significant public health threat. ZIKV exhibits a wide array of non-vector borne human transmission routes, such as sexual transmission, transplacental transmission and blood transfusion. Detection and surveillance of ZIK [....] » Read More
Title : SARS-CoV-2 lineage identification from massive parallel sequencing data: An analytical workflow
Valeria Di Lollo, Istituto Zooprofilattico Sperimentale (IZS), Italy
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of the ongoing outbreak of the disease known as coronavirus disease 2019 (COVID-19). The genetic plasticity of SARS-CoV-2 has determined the emergence of numerous variants with enhanced adaptive c [....] » Read More
Title : Phage therapy in clinical practice: Experience in chronic bone infections
Alfonso Recordare, Dell Angelo Hospital, Italy
Difficult-to-treat infections have led to a renewed interest in phage therapy as adjunct to conventional surgical and antimicrobials treatments. Chronic bone infections are biofilm-related infections difficult to eradicate; in vitro data indicate that phages are active against bi [....] » Read More
Title : Efficacy and safety of inhalation of nebulized ethanol in covid-19 treatment. A randomized clinical trial
Pietro Salvatori, Private Practice, Italy
Background: This study was designed to evaluate the efficacy and safety of nebulized ethanol (EtOH) in the treatment of COVID-19. Methods: A RCT of 99 symptomatic and RT-PCR-positive patients admitted to a hospital receiving Remdesevir-Dexamethasone was conducted. They were ra [....] » Read More
Title : The rationale of ethanol inhalation for disinfection of the respiratory tract in SARS-CoV-2-positive asymptomatic subjects
Pietro Salvatori, Private Practice, Italy
The severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic is a major health concern affecting socio-economic lives. As with other highly contagious diseases, it is of utmost importance to identify and treat the healthy carriers or positive asymptomatic subjects (P [....] » Read More
Title : No cold chain molecular workflow for detecting and differentiating plasmodium
Sara Sentre Domingo, CerTest Biotec, Spain
Background Malaria (or paludism), is a mosquito-borne parasitic disease caused by Plasmodium, is a leading cause of death and disease in many developing countries. The objective of this study was to determine the clinical performance of VIASURE Malaria Real Time PCR Detection Ki [....] » Read More
Title : Inflammatory markers and hematologic indices in the prediction of severity of COVID-19: A single center study in southern philippines
Meccar Moniem H. Elino, Southern Philippines Medical Center, Philippines
Background: Various diagnostic tests across COVID-19 literatures were employed as surrogate markers in COVID-19, wherein interleukin-6 (IL-6) – gauge for cytokine storm or impending severity – is not readily available among the third world countries particularly the P [....] » Read More
Title : Clinical outcomes of different treatment approaches under compassionate use among patients with moderate to severe COVID-19 pneumonia admitted in a private tertiary hospital
Mark Leoven O. Lumalang, Adventist Medical Center Manila, Philippines
Background: The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS Cov-2) is a major global public health and socioeconomic crisis. Patients may present with mild symptoms to severe respiratory distress causing major impact in morbidity and mortality. While treat [....] » Read More
Title : Prevalence, clinical features and outcomes of hepatitis b and hepatitis c co-infections among HIV-positive adults in a philippine tertiary hospital from january 2015 to december 2019
Maria Luisa R. Maranan, San Lazaro Hospital, Philippines
Introduction: The Philippines is one of the countries with the fastest rising growth rate of HIV in the Asia Pacific. HIV, HBV and HCV have similarities in terms of risk factors and transmission routes, hence co-infection with HBV and/or HCV are said to be common in HIV-positive [....] » Read More
Title : Barriers to antiretroviral medication adherence in people living with HIV (PLHIV) at the time of COVID-19 pandemic in the Philippines
Philip John Joves, Adventist Medical Center Manila, Philippines
Background: Adherence to antiretroviral therapy (ART) reduces morbidity and mortality among people living with HIV (PLHIV) by suppression of viral replication, restoration and preservation of immune function. However, poor adherence with ART may lead to treatment failure and dea [....] » Read More
Title : Point prevalence survey of antimicrobial use in a tertiary training hospital in Zamboanga City, Philippines, 2022
Sebar Sala, Zamboanga City Medical Center, Philippines
Background: The increasing prevalence of infections due to Antimicrobial Resistance (AMR) constitutes a serious threat to healthcare systems. This study investigated the trends and compliance to antimicrobial prescribing to identify potential areas for quality improvement. Met [....] » Read More
Title : The association of platelet-lymphocyte and neutrophil-lymphocyte ratios to in hospital outcome among admitted diabetic patients with COVID -19 infection.
Ernan N. Baluis, Adventist Medical Center Manila, Philippines
Background: In COVID-19 a dysregulated immune response and cytokine storm is the underlying mechanism that determines the adverse outcome. The Neutrophil/Lymphocyte Ratio(NLR) and Platelet/Lymphocyte Ratio(PLR) have been considered as systemic inflammatory response markers. O [....] » Read More
Title : Foreign fungus: Candida duobushaemulonii bloodstream infection in an immunocompromised host at Baguio General Hospital & Medical Center: A case report
Hideliz Marie G Pascua, Baguio General Hospital and Medical Center, Philippines
Candida duobushaemulonii is a yeast that belongs to the Candida haemulonii species complex. Similar to Candida auris which is an emerging global health threat, C. duobushaemulonii is a major concern in the healthcare system as it is often multidrug resistant. Prese [....] » Read More
Title : Triple threat: Severe COVID-19-strongyloidiasis-taeniasis co-infection: A case report
Helen Jane Polido, Baguio General Hospital and Medical Center, Philippines
Introduction Coronavirus disease 2019 (COVID-19) caused by the virus SARS-CoV-2 is an ongoing global pandemic which led to loss of human life worldwide and presents an unprecedented challenge not only to public health but also to the food systems and the world of work.1 In the P [....] » Read More
Title : Rhabdomyolysis in a covid-19 critical patient
Roxanne M Figueroa, Baguio General Hospital and Medical center, Philippines
Rhabdomyolysis is a life-threatening disorder that manifests with myalgia, fatigue, and pigmenturia, with a mortality rate as high as 59%. Acute renal failure which occurs in 13-50% of cases. Myalgia and fatigue are common constitutional symptoms in patients with viral infection [....] » Read More
Title : Clinical outcomes of different treatment approaches under compassionate use among patients with moderate to severe COVID-19 pneumonia admitted in a private tertiary hospital
Anna Mayleen A. Fermin, Adventist Medical Center - Manila , Philippines
Background: The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS Cov-2) is a major global public health and socioeconomic crisis. Patients may present with mild symptoms to severe respiratory distress causing major impact in morbidity and mortality. While treat [....] » Read More
Title : Lack of association between YEASTONE antifungal susceptibility of cryptococcus meningitis cerebrospinal fluid isolates and risk factors for poor prognosis
Jeng How Yang, New Taipei Municipal TuCheng Hospital, Taiwan
Background: Cryptococcal meningitis (CM) is associated with high mortality. The relation between antifungal susceptibility and treatment outcomes is not well characterized. There is paucity of surveillance data of cerebrospinal fluid (CSF) isolates of cryptococcus investigated wi [....] » Read More
Title : Effects of the natural compound on SARS-CoV-2 spike protein-mediated metabolic alteration in THP-1 cells explored by the 1H-NMR-based metabolomics approach
Gyaltsen Dakpa, National Chung-Hsing University, Taiwan
A change in metabolism is one of the hallmarks of coronavirus disease 2019 (COVID-19) that cause severity and mortality. The mechanism of SARS-CoV-2 spike protein-mediated perturbations of metabolic pathways and modulation of antcin A, a steroid-like compound isolated from Taiwan [....] » Read More
Title : Camels as one health bio-indicators: Example of vector borne pathogens
Selmi Rachid, General Directorate of Military Health, Tunisia
Livestock constitute habitual hosts and carriers for several infectious pathogens which may represent a serious public health concern and lead to a wide economic losses. Camels are increasingly the subject of several scientific investigations, showing that they are receptive and [....] » Read More
Title : First molecular identification of mermithid nematodes (Nematoda: Mermithidae) infecting Culicoides spp (Diptera: Ceratopogonidae) in Tunisia
Darine Slama, University of Monastir, Tunisia
The Mermithid nematode parasitizes many biting midges worldwide, causing changes in different parts of their body, especially intersexes phenomena. In Tunisia, and to our knowledge any study was recorded to know if this phenomenon exists and to identify the nematode species invol [....] » Read More
Title : Maternal and fetal outcome among pregnant women with vaginal dysbiosis: A systematic review and meta-analysis
Kenfack Josiane, University of YaoundeI-Cameroon, Cameroon
Background: Women of childbearing age are commonly affected by bacterial vaginosis (BV). Maternal-fetal outcomes associated with BV during pregnancy can be fatal for both the mother and the newborn. In this review, we aim to identify maternal and fetal outcomes in pregnant women [....] » Read More
Title : Onchocerciasis drug development: From pre-clinicals to humans
Adela Ngwewondo, Institute of Medical Research and Medicinal Plants Studies, Cameroon
Twenty diseases are recognized as neglected tropical diseases (NTDs) by World Health Assembly resolutions, including human filarial diseases. The end of NTDs is embedded within the Sustainable Development Goals for 2030, under target 3.3. Onchocerciasis afflicts approximately 20. [....] » Read More
Title : Profiling cytokines response against sars-cov 2 in a cameroonian population
Matabou Tene Sosthene Hiillary, Centre for Research on Emerging and Reemerging Diseases, Cameroon
BACKGROUND: Coronavirus disease 2019 (COVID-19) is an acute, highly transmissible infectious disease. SARS-CoV-2 is the causative agent and is associated with a cytokine storm characterized by increased plasma concentrations of IL-2, 6, and 10. INF-α2 has been reported to [....] » Read More
Title : First evidence on the circulation of trypanosoma brucei gambiense in manoka island in littoral region of cameroon: Epidemiological implications and perspectives
Mbida Mbida Jean Arthur, university of douala, Cameroon
A survey on Human African Trypanosomiasis (HAT) is essential for prevention and preparedness for epidemics. The objective of the study was to assess the circulation of human trypanosomes and their vectors across quiescent HAT foci of the Littoral Region of Cameroon. A descript [....] » Read More
Title : Seroprevalence of cross-reactive anti-SARS-CoV-2 antibodies in pre-COVID-19 samples collected from cameroonian women during pregnancy and at delivery
Seumko o Ndeumou Medouen Reine, University of YaoundeI-Cameroon, Cameroon
Background: The COVID-19 Pandemic still causes significant morbidity and mortality worldwide. Significantly more cases of COVID-19 and its related deaths are reported in High-Income countries compared to Low- and Middle-Income Countries (LMIC). This might be due to pre-exist [....] » Read More
Title : Characteristics of healthcare workers infected with COVID-19: A retrospective descriptive study in a university hospital, Jeddah, Saudi Arabia
Saleh Binmahfooz, King Abdulaziz University, Saudi Arabia
Introduction: Coronavirus disease 2019 (COVID-19) has become the most devastating public health issue in the entire world. The disease has been spreading internationally and has swept the world in a short period. It stated as a pandemic by the World Health Organization on March [....] » Read More
Title : Endogenous sex hormone levels and risk of ischemic stroke: A systematic review and meta-analysis
Pradeep Kumar, AII India Institute of Medical Sciences, India
Background and aims: Ischemic stroke (IS) causes significant mortality worldwide and has higher incidence among men than women. In this study, we investigated the risk-association of endogenous sex hormones in males and females with ischemic stroke. Methods: Comprehensive lite [....] » Read More
Title : Facilitators and challenges for integrating campaigns for control of neglected tropical diseases in North India
Preetha G S, International Institute of Health Management Research, India
Integrated health campaigns with multiple interventions can potentially lead to improved population coverage, service delivery, quality assurance and time efficiencies. We conducted a study in Uttar Pradesh where disease control campaigns are held routinely to achieve national he [....] » Read More
Title : Epidemiology of leprosy identified through active case detection in six districts of Nepal
Ram Kumar Mahato, Epidemiology and Disease Control Division, Nepal
Background Nepal has achieved and sustained elimination of leprosy as a public health problem since 2009, but 17 districts and 3 provinces have yet to eliminate the disease. Pediatric cases and grade-2 disabilities (G2D) indicate recent transmission and late diagnosis respectiv [....] » Read More
Title : Clinico-epidemiological presentation of acute encephalitis syndrome in patients visiting a tertiary hospital in Kathmandu, Nepal: A descriptive cross-sectional study
Bidhi Dhital, Charak Memorial Hospital Pvt. Ltd, Nepal
Acute encephalitis syndrome (AES) is defined as acute onset of fever and a change in mental status (including symptoms such as confusion, disorientation, coma or inability to talk) and/or new onset of seizures (excluding simple febrile seizures) in a person of any age at any time [....] » Read More
Title : Phenolic, antioxidant quantification and NMR analysis of Moringa oleifera L. plant extracts
Zimasa Busisiwe Dubeni, University of Fort Hare, South Africa
Moringaceae, one of the most prominent plant families, includes species with high economic, ecological, and medicinal importance because of their potent phytochemicals. M. oleifera, commonly known as Horse radish is a small, fast, growing, evergreen, deciduous tree. It is among t [....] » Read More
Title : Hypervirulent klebsiella pneumoniae in a south african tertiary hospital – clinical profile, genetic determinants and virulence in caenorhabditis elegans
Likhona Dingiswayo, Medical Microbiology, Free State, South Africa
A distinct strain of Klebsiella pneumoniae (K. pneumoniae) referred to as hypervirulent (hvKp) is associated with invasive infections such as invasive pyogenic liver abscess in young and healthy individuals. In South Africa, limited information is known about the prevalence and v [....] » Read More
Title : Genomic characterisation of acinetobacter baumannii associated with neonatal sepsis and stillbirths in a south african population
Bonginkosi Shabangu, University of Witwatersrand, South Africa
BACKGROUND: The proposed study will characterise the genomes of multi-drug resistant hospital-acquired invasive Acinetobacter baumannii (A. baumannii) which overwhelmingly contributes to neonatal deaths, particularly in low-middle income countries (LMICs) where the burden of [....] » Read More
Title : Frequency of active cough among paragonimiasis patients in coastal communities in Calabar, Nigeria
Emmanuel Chukwunenye Uttah, University of Agriculture & Environmental Sciences, Nigeria
This study was aimed at investigating the epidemiology of paragonimiasis in two selected coastal communities in Calabar suburb, namely Akpabuyo and Calabar South. Seven sputum examinations per person were carried out for the presence of Paragonimus uterobilateralis eggs/ova. Poss [....] » Read More
Title : The burden of human parechoviruses on children in oman
Aws Sami Sulaiman Al-Farsi, Sultan Qaboos University, Oman
Objectives To study the burden, clinical and laboratory features and outcome of Human Parechoviruses (HPeVs) infection among children managed at a tertiary hospital in Oman. Methods: This is a retrospective study of children (< 18 years of age) with molecular proven HPeV in [....] » Read More
Title : Antibiotic prescription trends among pediatric population admitted in tertiary care hospitals of rawalpindi, analytical cross sectional study
Sana Iqbal, National Institutes of Health, Pakistan
Objective; to demonstrate the antibiotic usage and trends among pediatric patient admitted in tertiary care hospital of rawalpindi Study Design; Analytical cross sectional study Place and Duration of Study: pediatric in patient department of two tertiary care hospitals of R [....] » Read More
Title : Preparation of frozen bivalent babesial vaccine and its efficacy evaluation in calves
Muhammad Fiaz Qamar, College of Veterinary & Animal Sciences, Jhang, Pakistan
This study was aimed to prepare a frozen bivalent babesial vaccine and evaluate its efficacy in calves. Babesiosis is a tick-borne disease caused by the parasite Babesia, and is a major problem for cattle production. A bivalent vaccine was prepared using two Babesia species, Babe [....] » Read More
Title : Operational effectiveness of 1, 2, and 3 covid-19 vaccine doses against hospitalization of patients reporting for covid-19 test in west kenya
Shem Sam, Lake Region Economic Bloc, Kenya
Introduction COVID-19 vaccines are administered to protect populations from SARS-CoV-2 infections. Even in case of breakthrough infections, current vaccines protect people against severe outcomes, that is, acute illness, hospitalization, and fatality. Prevention of patients fr [....] » Read More
Title : Genetic diversity and molecular epidemiology of mycobacterium tuberculosis from pleural specimen in Morocco
Bouklata Nada, National Institut of Hygiene (INH), Morocco
Objectives: Development of pleural form of tuberculosis is still poorly understood, particularly in quite high-endemic countries like Morocco. Genotypic studies may help understanding the transmission routes of Mycobacterium tuberculosis strains in pleural TB patients. Materi [....] » Read More
Title : Software product for clinical and immunological prognosis of the severity of covid-19
Nodirjon Ruzimurodov, Institute of Immunology and human genomics, Uzbekistan
One of the global problems at the moment is the Coronavirus (COVID-19). Everyone already knows all the consequences of COVID-19. In addition, determining the course of the severity of the disease is also an important factor for both the patient and the medical staff. Until now, t [....] » Read More
Title : Increase access to Mental Health Care ( MHC) services and HIV/AIDS awareness, testing and support among the Young LGBTQ+ community through use of social media in Mityana city
Ssembatya Benard, Vijana Na Children Foundation, Uganda
Introduction: Research shows that young LGBTQ+ community in Mityana City have less access to MHC services and HIV information, testing and support thereby being at a risk of HIV infections. Vijana Na Children Foundation-Uganda (VINACEF) used social media to provide access [....] » Read More
Title : Comparison the immune response of FMD vaccine developed using different adjuvants in mice.
Tedros, Comsats University, Eritrea
Ethiopia is thought to have the most significant livestock population in Africa. The appearance of contagious diseases can excessively hinder economic development .Foot and mouth disease occurs throughout the country, with the highest incidence reported in central Ethiopia. Foot- [....] » Read More
Title : High prevalence of cryptosporidium infection in patients suffering from colorectal cancer
Hossein Mahmoudvand, Lorestan University of Medical Sciences, Iran (Islamic Republic of)
The present investigation was designed to study the prevalence of cryptosporidiosis in the colorectal cancer patients compared to the healthy subjects. The present descriptive case-control study was performed on 174 subjects including 87 healthy people and 87 patients with colore [....] » Read More
Title : Importance of fungal sinusitis in diabetic patients
Batool Sadeghi-Nejad, Abadan University of Medical Sciences, Iran (Islamic Republic of)
Fungal sinusitis usually is observed in immunocompromised individuals but may be appear in healthy people. Fungal sinusitis is appeared in invasive, non-invasive, allergic and mycetoma (aspergilloma) forms. Originally this disease was a most commonly descried in ketoacidosis poor [....] » Read More
Title : Antigen-specific CD4+T cell activation, proliferation and functional markers of adult pulmonary tuberculosis patients in Addis Ababa, Ethiopia.
Ahmed, Debre Markos University, Ethiopia
The poor diagnostic and prognostic potential of existing tools potentially hinder the tuberculosis (TB) prevention and control program. Currently, antigen-specific blood-based biomarkers have become alternatives to improve the diagnostic and prognostic challenges related to tuber [....] » Read More
Title : Utility of the loop-mediated isothermal amplification assay for the diagnosis of visceral leishmaniasis from blood samples in Ethiopia
Dawit Gebreegziabiher Hagos, Mekelle University, Ethiopia
Rapid and accurate visceral leishmaniasis (VL) diagnosis is needed to initiate prompt treatment to reduce morbidity and mortality. Here, we evaluated the performance of loop-mediated isothermal amplification (LAMP) assay for the diagnosis of VL from blood in an endemic area in Et [....] » Read More
Title : Why people die of active tuberculosis in the era of effective chemotherapy in Southern Ethiopia: A qualitative study
Belay Boda, Arba Minch University, Ethiopia
Background: High TB mortality is increasingly understood as an indicator of different problems in the health system and community. Limited awareness of TB in the community, restricted accessibility and/or quality of health services can hamper survival. Exploration and analysis of [....] » Read More
Title : Social labeling and stigmatization of people with healed CL scars using retrospective and introspective experiences: Implication to intervention
Binega, Mekelle University, Ethiopia
Leishmaniasis is one of the most neglected tropical diseases (NTDs), caused by a parasite of the genus Leishmania which is transmitted through a sand-fly vector and mostly affects the poorest of the poor. It is characterized by physiological and clinical manifestations of lesions [....] » Read More
Title : The threat to the world health due to the war in Ukraine
Nataliia Liakhovska, Poltava State Medical University, Ukraine
Many historical epidemics have been associated with natural or manmade disasters. Military events cause the spread of infections. This has been known for thousands of years. There are many scientific papers that emphasize the need for early action on the center of possible spread [....] » Read More
Title : Changing mode of infection of corona and climate change.
Nitosh Kumar Brahma, IEI(The Institution of Engineers, India), IGE(The Institute of Genetic Engineering), India
Mutational variation of COVID-19 and the prophylaxis of its infective mode corona to human are climate dependent. The said molecular biological problem could be explained in following manner. It is proposed that transcription aspects of corona are genetic dependent and ACE is the [....] » Read More
Title : AAIR (Antiadherent immune response) and MRHU (D-mannose resistant hemagglutinating of human erythrocyte non- conjugative plasmid) and possible proposal of global vaccination.
Nitosh Kumar Brahma, IEI(The Institution of Engineers, India), IGE(The Institute of Genetic Engineering), India
Virulence factors of pathogenic bacteria (adhesins, toxins, invasions, protein secretion systems, iron uptake systems, and others) may be encoded by particular, regions of the prokaryotic genome as pathogenicity islands of Escherichia coli, at 10–200, kilobases (kb) G+C con [....] » Read More
Title : Susceptibility pattern of candida species isolated from vaginal candidiasis to fluconazole, voriconazole and extracts of acalypha wilkesiana muell. Arg. and senna alata linn. leaves.
Abidemi Nurat Akinbami, University of Ibadan, Nigeria
Background Vulvovaginal candidiasis (VVC) is a fungal infection of the female lower genital tract - the vulva and the vagina, caused by Candida species. Vulvovaginal candidiasis has the following therapeutic challenges; limited number of effective antifungal agenthe ts, toxicity [....] » Read More
Title : Early osteoarticular material infections: Clinical, diagnostic, therapeutic and progressive features
Ines Chalbaoui, Mohamed Kassab Institute of Orthopedics, Tunisia
Introduction : Early osteoarticular material infection is becoming more common these days. It requires complex and multidisciplinary management. The objective is to study the clinical, diagnostic, and therapeutic particularities of early osteoarticular material infection. Mat [....] » Read More
Title : Potential zoonotic disease associated with straw colored fruit bat (Eidolon Helvum) in Nigeria
Aladejana Oluwatoyin Modupe, Redeemers University, Nigeria
Bats (Chiroptera) are taxonomically and ecologically diverse group of animals found in almost all habitats and trophic levels. There are over 1,300 species of bats documented worldwide. Nigeria supports almost a third of the bat diversity known in Africa. Bat is commonly as [....] » Read More
Title : Detection of microsporidial infections in domestic pigeons (Columba livia domestica) in northwest Iran
Monireh Khordadmehr, University of Tabriz, Iran (Islamic Republic of)
Microsporidia, are unicellular and obligate intracellular eukaryotes considered as emerging opportunistic human and animal pathogens. To determine microsporidiosis in domestic pigeons in Iran privately-owned pigeons (n=100) presenting weight loss and diarrhea were tested for micr [....] » Read More
Title : Impact of adaptive mosquito behavior and insecticide-treated nets on malaria prevalence
Josephine Kagunda, University of Nairobi, Kenya
Malaria prevalence in sub-Saharan Africa remains high. Kenya for example, recordsabout 3.5 million new cases and 11 thousand deaths each year.1 Most of these cases and deaths are among children under five. The main control method in malaria endemic regions has been through the us [....] » Read More
Title : Study the issue of sleep disturbance in Parkinson's disease
Khudoydotov Yodgor, Tashkent medical academy, Uzbekistan
Objective: One of the most frequent non-motor manifestations of parkinson (PD) - pain. The frequency of chronic pain in PD lasting more than three months, according to different authors, is from 40 to 70% and exceeds it in general population from 20 to 44%. Assume pain in patient [....] » Read More
Title : Inhibitory effects of limonene on candida albicans virulence-related traits
Saiema Ahmedi, Jamia Millia Islamia, India
A major global problem is the severe toxicity of conventional antifungal medications and multidrug resistance. Investigation of new substances with outstanding therapeutic potential is necessary. In this work, the antifungal potential of limonene, a secondary metabolite present i [....] » Read More
Title : To understand and address the complex issues faced by individuals with leprosy (Hansen’s Disease) in Malaysia: A transdisciplinary research approach
Norana Abdul Rahman, Perdana University Malaysia, United Kingdom
Introduction: Leprosy, or Hansen's disease, is a chronic infectious disease caused by a bacillus, Mycobacterium leprae. The infection has a long incubation period, primarily affecting the skin, mucous membranes, and peripheral nerves. Leprosy is curable with multidrug th [....] » Read More
Title : Translational vaccinomics and structural filtration algorithm to device multiepitope vaccine for catastrophic monkeypox virus
Satyendra SIngh, Central University of Rajasthan, India
Background: The most recent monkeypox outbreak began in April of 2022, and the initial confirmed case was reported on May 7. The disease then spread to 70 non-endemic countries in less than 15 days, prompting the World Health Organization to declare monkeypox a public health emer [....] » Read More
Title : Identification of FDA-approved drugs with triple targeting mode of action for the treatment of monkeypox: A high throughput virtual screening study
Varshita Srivastava, Central University of Rajasthan, India
According to the Center for Disease Control and Prevention, as of August 23, 94 countries had confirmed 42,954 Monkeypox Virus cases. As specific monkeypox drugs are not yet developed, the treatment depends on repurposed FDA-approved drugs. According to a recent study, the Monkey [....] » Read More
Title : Gum odina prebiotics: An emerging gut modulating approach in the preventing chronic non communicable diseases
Debmalya Mitra, ICMR National Institute of Cholera and Enteric Diseases, India
Colitis is a multifaceted disease which is a global threat in the present times. It is hypothesised that novel prebiotics like Gum Odina (GO) are emerging as preventive therapy to combat chronic gut diseases due to their ease of incorporation into diet and established health bene [....] » Read More
Title : Microbial adhesion capacity on orthopedic implants
Klemen Bohinc, Faculty of Health Sciences, Slovenia
The application of orthopedic implants in our body is associated with the possibility of infection. To have the infections under control interactions between microorganisms and implant surfaces needs to be understood. Therefore, in this presentation we consider the microbial adhe [....] » Read More
Title : Measles sans rash - an atypical cause of new-onset refractory status epilepticus (NORSE)
Kushal Kalvit, Tata Memorial Hospital, India
Introduction NORSE is an umbrella term with different aetiologies. The usual suspects are structural lesions, infections, toxins, metabolic causes, autoimmune or paraneoplastic encephalitis. Measles is a common infection that presents with a rash and is typically self-limiting. [....] » Read More
Title : Knowledge, attitude and practices towards COVID-19 pandemic among tamil nadu fisherman community
Shivanand, Kalasalingam Academy of Research and Education, India
Background: In India, a collective range of measurement had been adopted to control the massive spread of the COVID-19 pandemic. Such overall population could significantly influence knowledge, attitude and practice (KAP) towards COVID-19. Field survey-based study was conducted [....] » Read More
Title : Lassa fever among hospitalized patients in Ebonyi State, Nigeria: A 5-year retrospective review
Ugochukwu Clement Chukwunenye, Medecins San Frontieres, Nigeria
Background: Lassa fever is a viral haemorrhagic disease endemic in West Africa. Between 300,000 to 500,000 people get infected annually, with nearly 5000 deaths. In the last five years, several programs and interventions were employed in Ebonyi State to prevent and manage Lassa f [....] » Read More
Title : Carriage of neisseria meningitidis among university students living in residential colleges, Dunedin, New Zealand
Susan Jack, University of Otago, New Zealand
Invasive meningococcal disease is a severe disease caused by Neisseria meningitidis that can present as septicaemia or meningitis and may lead to disability or death. Nasopharyngeal carriage of N. meningitidis may occur in up to 15% of the general population with a higher p [....] » Read More
Title : Role of vitamins (ABCDE) for the risk of stroke: A systematic review and meta-analysis
Pradeep Kumar, AII India Institute of Medical Sciences, India
Our systematic review and meta-analysis of the association between intake of vitamins A, B12, C, D, and E and the risk of stroke indicate that higher vitamin B12 intake may be associated with a reduced risk of stroke, while the effect of vitamin C on stroke risk is uncertain. No [....] » Read More
Title : Concept elicitation, cognitive debriefing and usability testing of COVID symptoms diary
Susan M Dallabrida, SPRIM US LLC, United States
Objective: COVID-19, caused by a coronavirus, SARS-CoV-2, has been the cause of the global pandemic from 2020-2022. Due to COVID-19’s novelty, there exist no validated patient reported outcome (PRO) tools that allow for proper evaluation of patient infection severity based [....] » Read More
Title : Calcium-dependent restriction of HIV-1 by S100A9 in myeloid cells
Hertel Quentin, University of Montpellier, France
The alarmin S100A9 is a calcium-binding protein known for its pro-inflammatory extracellular role in the immune response against pathogens in the form of a S100A8/S100A9 heterodimer called calprotectin. However, S100A9 was recently shown to exert an intracellular antiviral effect [....] » Read More
Title : Are water buffaloes susceptible to lumpy skin disease? A pilot study
Elisabetta Di Felice, Experimental Zooprophylactic Institute of Abruzzo and Molise Giuseppe Caporale, Italy
Lumpy skin disease (LSD) is a viral disease of cattle and water buffalo characterized by cutaneous nodules, biphasic fever, oral and nasal discharge, accompanied by general lymphadenitis. Clinical infections in cattle range from sub-clinical to acute form and the disease is assoc [....] » Read More
Title : Potential sars-cov-2 susceptibility of cetaceans stranded along the italian coastline
Tania Audino, Istituto Zooprofilattico Sperimentale di Piemonte, Italy
Due to marine mammals’ demonstrated susceptibility to SARS-CoV-2, based upon the homology level of their angiotensin-converting enzyme 2 (ACE2) viral receptor with the human one, alongside the global SARS-CoV-2 occurrence and faecal contamination of the river and marine eco [....] » Read More
Title : Clinical and microbiological profile and factors affecting outcome among pediatric febrile neutropenia patients with hematologic malignancies in a private tertiary hospital in the Philippines
Josh Nathan L. Ngai, St. Luke's Medical Center, Philippines
Introduction: Febrile neutropenia is a major cause of morbidity and mortality in children with hematologic malignancies. It presents as a serious, potentially fatal condition complicating cancer treatment associated with significant morbidity and mortality. To date, established n [....] » Read More
Title : A clinical profile of side effects of covid-19 pfizer-biontech mrna vaccine among children aged 12-18 years old in metro manila
Emelia Katrina I. Cafugauan, St. Lukes Medical Center, Philippines
Reluctance to COVID 19 vaccination that is secondary to limited knowledge on side effects, reporting of serious adverse reactions and emergency use of the vaccine is a major problem that could hinder achieving herd immunity against COVID 19 infection. Continuous monitoring and re [....] » Read More
Title : The association of cycle threshold value with disease severity and biochemical outcomes among pediatric patients with rt-pcr confirmed covid-19 infection seen in a tertiary hospital
Maria Luz Isadora L. Timbancaya, St. Luke’s Medical Center, Philippines
Background. The gold standard in the diagnosis of COVID-19 infection remains to be through RT-PCR. This is done through the determination of a cycle threshold value. There have been conflicting studies as to whether the cycle threshold value can also be used to determine disease [....] » Read More
Title : Clinical outcomes of neonates born to Covid-19 positive mothers in a tertiary level private hospital
Patricia Abigail B. Miranda, St. Luke’s Medical Center, Philippines
COVID-19 infection is a novel viral illness which began as a local epidemic in December 2019 at Wuhan, China which quickly emerged into a pandemic by February 2020. The virus causes a spectrum of signs and symptoms, ranging from mild upper respiratory symptoms to acute respirator [....] » Read More
Title : Identifying BBK32 sequences mediating the borrelia burgdorferi catch bond adhesion mechanism
Pardis Riahi, University of Toronto, Canada
Lyme disease is caused by spirochete members of the Borrelia burgdorferi (B. burgdorferi) sensu lato species complex and is transmitted by Ixodes ticks (Stanek et al., 2012). Hematogenous (blood-borne/vascular) dissemination is critical for the spread of B. burgdorferi from the i [....] » Read More
Title : Profile of beta-lactamases in multidrug-resistant (MDR) acinetobacter baumannii strains in lithuania 2016-2017 and 2021-2022 years
Kristina Cerniauskiene, Lithuanian University of Health Science, Lithuania
Introduction: Acinetobacter baumannii (A. baumannii) is an important nosocomial pathogen that possesses not only intrinsic resistance to many classes of antibiotics, but also has a propensity for rapid development of antimicrobial resistance during treatment. Aims & O [....] » Read More
Title : Predicted coverage by 4CMenB and MenB-Fhbp vaccine against invasive serogroup B neisseria meningitidis isolated from 2017-2019 in Lithuania
Milda Pleckaityte, Vilnius University, Lithuania
The incidence of invasive meningococcal disease (IMD) in Lithuania was among the highest in Europe during the past two decades reaching an average of 2.24 cases/100,000 population. The vast majority of IMD cases were caused by serogroup B meningococci. In 2018, the only four-comp [....] » Read More
Title : Prevalence and characteristics of neisseria meningitidis carriage among high school students from the Vilnius region, Lithuania
Aurelija Žvirbliene, Vilnius University, Lithuania
Neisseria meningitidis causes invasive meningococcal disease (IMD), which is associated with significant mortality and long-term consequences, especially among young children. The incidence of IMD in Lithuania was among the highest in European countries during the past two decade [....] » Read More
Title : Engystol may reduce lung pathology in SARS-CoV-2 infected hamsters: A pilot study
Kathrin Weyer, Heel GmbH, Germany
Despite the introduction of vaccines and new anti-viral therapies, the COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to be a serious global public health crisis. The emergence of new viral variants that escape protection from [....] » Read More
Title : Analysis of candida spp infections in adult intensive care units in santander, Colombia
Juanita Leon, Cancer Research and Treatment Center Luis Carlos Sarmiento Angulo, Colombia
Invasive mycoses are linked to higher mortality and morbidity (1). Most of these infections are hospital acquired, frequent in intensive care units and account approximately for 15% of healthcare related infections (1, 2). The aim of this paper is to analyse available data on hea [....] » Read More
Title : Leptospirosis in rural colombia: Moniquira’s case series in 2022
Jairo Cardenas, Hospital Regional de Moniquira, Colombia
Introduction: Moniquira is a small town in Colombia, with 20,800 inhabitants. The main economic activity is agriculture. Leptospirosis is a zoonotic disease related with contaminated water, animals, and poverty. The aim of this paper is to describe the clinical course of the dise [....] » Read More
Title : In vitro activity of colistin against pseudomonas aeruginosa with difficult-to-treat resistance isolates from critically ill burn patients
Houda Limam, Faculty of Medicine of Tunis, Tunisia
Pseudomonas aeruginosa is an opportunistic pathogen, commonly causing hospital-acquired infections in burn patients. P. aeruginosa with difficult-to-treat resistance (DTR-PA) is resistant to all of the following: piperacillin-tazobactam, ceftazidime, cefepime, aztreonam, meropene [....] » Read More
Title : Sternal wound infection following open heart surgery: Incidence, risk factor, pathogen, and mortality
Mohsin Khared, King Abdulaziz University, Saudi Arabia
Surgical site infections (SSI) are a significant cause of morbidity and mortality after surgery. Due to its high morbidity and mortality rates after open-heart surgery, sternal wound infection (SWI) is one of the most important consequences to avoid and manage. Staphylococcus spe [....] » Read More
Title : CD11c+ dendritic cells are required for survival in murine LPS induced ALI
Yuying Tang, Southeast University, China
Purpose : Dendritic cells (DCs) are always known as professional APCs which play a crucial role in the link between innate and adaptive immunity. DCs can initiate both immunity and immunological tolerance , which means efficacy either in amelioration or exaggeration of infl [....] » Read More
Title : Scaffolding role of TcpB in disrupting TLR4-Mal interactions: Three to tango
Uzma Saqib, DAVV academic University, India
Toll/interleukin-1 like receptors (TLRs) are membrane-spanning proteins crucially involved in innate immunity. On activation, the cytoplasmic toll/interleukin-1 receptor (TIR) domains of these receptors undergo homo- or heterodimerization. Brucella sp. are bacterial pathogens tha [....] » Read More
Title : Tuberculosis meningoencephalitis and drug side effects : the important role of early diagnosis and therapy modification for better outcome in indonesia
Ratna Ayu Cahaya Kusuma Dewi, Diponegoro University, Indonesia
Background Tuberculous (TB) meningoencephalitis is a major global health problem and the most severe form of extrapulmonary TB with high mortality rate. In case Mycobacterium tuberculosis (MTB) is suspected as the etiology, early diagnosis and treatment with anti-tuberculosis dr [....] » Read More
Title : Co-infection of severe leptospirosis and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with multiple organ involvement in indonesia
Elfian Rachmawati, Diponegoro University, Indonesia
Leptospirosis co-infection and the pathogenesis of SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) play a significant part in the emergence and progression of SARS-CoV-2 infection by enhancing the difficulty of identification, management, and outcome of COVID-19 well [....] » Read More
Title : Culture-proven bloodstream infection in children managed at a tertiary hospital in oman
Marwah Saud Al-Thuhli, Oman Medical specialty Board, Oman
Objectives: Bloodstream infection (BSI) in children causes significant morbidity and mortality and is associated with longer hospital stays and higher healthcare costs. Our objective is to study the incidence and risk factors and identify causative organisms and outcomes of BSI a [....] » Read More
Title : Culture-proven acute bacterial meningitis and PCR-proven acute viral meningitis in children at tertiary hospital in Oman: 10-year experience
Nidhal Al Harrasi, Oman Medical Specialty Board, Oman
Background: Acute meningitis is an inflammation of the tissue surrounding the brain, commonly caused by viruses and bacteria. The typical clinical manifestations of acute meningitis include fever, headache, neck stiffness and change in mental status 5,8. The diagnosis is made by [....] » Read More
Title : Distribution of tick-borne diseases in the samarkand region
Yarmuhamedova Nargiza, Samarkand State Medical University, Uzbekistan
The problems of infections transmitted by sucking a tick are due to the expansion of the distribution area of ticks and an increase in the incidence of tick-borne infections. Farm animals that make up the agrobiodiversity of Uzbekistan are at risk of disease with numerous pathoge [....] » Read More
Title : Comparison of susceptibility testing methods with “MECA” and “CFR” gene prevalence among Coagulase-negative Staphylococcus for determining methicillin and linezolid resistance- a prospective study from Delhi.
Devanshi Sharma, Hamdard Institute of Medical Science and Research, India
Background: CoNS, a major commensal of skin, now a notable cause of nosocomial infections, especially in patients undergoing surgical procedures. In previous decades, the β-lactams, most efficient weapons to control CoNS infection, have now blunted progressively. CoNS have [....] » Read More
Title : Determinants of vaccine coverage and acceptability of malaria vaccine in children aged 6-23 months in Malawi: A healthcare provider’s perspective.
Dumisile Sibongile Nkosi, University of Siena, Malawi
Background Malawi's 28 districts saw a rise in DPT3 coverage from 84% to 94% between 2016 and 2020, however, only 78% of the districts achieved >80% coverage. This indicates that there is still a gap in childhood vaccine coverage within the country. Objectives The ma [....] » Read More
Title : Evaluation of the national immunization program by estimating immunoglobulin G antibody prevalence of measles and rubella in Lao People's Democratic Republic
Chansay Pathammavong, National Immunization Program, Lao, People's Democratic Republic
Objective: To eliminate measles and rubella, it is critical to develop strategic and efficient immunization programs. This study aimed to evaluate the population immunity and the measles-rubella program's effectiveness by estimating anti-measles and anti-rubella IgG prevalenc [....] » Read More
Title : A strong dominance in the spread of influenza viruses over that of the SARS-CoV-2 during the 2022/2023 season in Bulgaria
Ivelina Trifonova Trionova, National Centre of Infectious and Parasitic Diseases, Bulgaria
After a period of two seasons of absence (2020/2021) or low prevalence (2021/2022) of influenza viruses, the 2022-2023 season was characterized by high influenza activity in Bulgaria. The objectives of this study were to analyze the pattern of influenza virus circulation with res [....] » Read More
Title : The causes of socially dangerous behavior during the Covid-19 pandemic.
Viacheslav Viktorovich Sushko, National University “Odessa Law Academy”, Ukraine
Introduction In Odessa, the police detained three people who thought they were sick COVID-19 and tried to infect others intentionally spit on the front door handles, on the handles of cars parked near shops, on the railing in the entrances of multi-storey buildings. This w [....] » Read More
Title : Molecular identification of trypanosoma brucei gambiense in naturally infected pigs, dogs and small ruminants confirms domestic animals as potential reservoirs for sleeping sickness in Chad
Joel Vourchakbe, Research professor at the University of Doba, Chad
Human African trypanosomiasis (HAT) has been targeted for zero transmission to humans by 2030. Animal reservoirs of gambiense-HAT could jeopardize these elimination goals. This study was undertaken to identify potential host reservoirs for Trypanosoma brucei gambiense by detectin [....] » Read More
Title : First detection of rifampin- and ofloxacin-resistant mycobacterium leprae in Chad (central africa)
Kirga Kabo Abakar, Catholic University of Central Africa, Chad
Antimicrobial surveillance and identification of the genetic basis of antimicrobial resistance provides important information to optimize patient care. The present study was an analytical crosssectional study aimed at determining the prevalence of rifampicin and ofloxacin resista [....] » Read More
Title : Animal bodies and human bodies in the face of guinea worm vulnerability in endemic areas of Chad
Jacob Maihondoum, Universite de Yaounde I, Chad
The present reflection starts from an alarming observation of the epidemiological situation of Guinea worm disease in rural Chad despite institutional mobilizations. In 2010, 16 cases were reported in humans and more than 1000 dogs were infected in 2016. The number of infections [....] » Read More
Title : Genetic characterization and frequency of T. gondii infection in stray cats in lorestan province, West of Iran
Ali Mirzapour, Islamic Azad University, Iran (Islamic Republic of)
Background: Cats as the definitive hosts of Toxoplasma gondii play an important role in parasite dispersion and outbreaks. To understand the transmission pattern of this parasite, the distribution of genetic diversity of T. gondii in cats is important. The current study aimed to [....] » Read More
Title : Global prevalence estimates of toxascaris leonina infection in dogs and cats
Ali Mirzapour, Islamic Azad University, Iran (Islamic Republic of)
Abstract: Toxascaris leonina is an ascaridoid nematode of dogs and cats; this parasite afects the health of these animals. This study estimated the global prevalence of Ta. leonina infection in dogs and Cats using random efects meta-analysis as well as subgroup, meta-regression a [....] » Read More
Title : Analysis of oral clinical manifestations and serological test results of secondary syphilis
Yuefeng Song, Medical School of Nanjing University, China
Objective: To analyze the correlation between serological test results and oral clinical manifestations of patients with secondary syphilis, and to provide reference for clinical diagnosis and treatment. Methods: From January 2016 to December 2020, 30 patients with secondary [....] » Read More
Title : Etiology of acute meningitis and encephalitis in hospitalized patients, Kazakhstan, 2019 - 2020
Bakhytkul Zhakipbayeva, Medical Epidemiologist CDC Central Asia, Kazakhstan
Introduction. Acute meningitis and encephalitis (AME) is a neurological inflammation associated with substantial morbidity and mortality caused by different pathogens. In Kazakhstan, comprehensive testing to identify viral causal pathogens is not routinely performed. Additionall [....] » Read More
Title : Effect of a novel anti-splash mask on preventing aerosol in dental practice
Wenmei Wang, Medical School of Nanjing University, China
Objective: To evaluate the effect of a new anti-splash mask on preventing aerosol pollution in dental clinics. Methods: The aerosol distribution characteristics in different types of splash operations were analyzed in dental clinics at first. Different splash operations were [....] » Read More
Title : Superinfected eschar in paraplegic patients: Epidemiological, clinical and therapeutic features
G.Garbouj, Infectious Diseases Department Kassab Institute of Orthopedics, Tunisia
Introduction: Secondary infection of eschar in paraplegic patients is a common but serious complication. It increases the burden of care for these patients and puts them at risk of death. The objective of our study was to describe the epidemiological, clinical, and therapeutic ch [....] » Read More
Title : Urinary bladder infection in spinal cord trauma
Shayma Hamza, kassab institute of orthopedics, Tunisia
Introduction: One of the major complications of spinal cord injury is the neurologic bladder that no longer empties autonomously. Urinary tract infection (UTI) is a major cause of morbidity and mortality in these patients, and the objective of our study was to describe the clinic [....] » Read More
Title : Osteoarticular brucellosis in an endemic region : Epidemio-clinical aspects, diagnosis, and treatment of 49 cases
Houda Limam, Faculty of Medicine of Tunis, Tunisia
Background : Brucellosis is a common bacterial zoonotic disease with a broad spectrum of clinical manifestations. Osteoarticular involvement is frequent, with a reported prevalence ranging from 27% in nonendemic regions to 36% in endemic regions. The sacroiliac and spinal joints [....] » Read More
Title : Treatment outcome of cutaneous leishmaniasis and its associated factors among admitted patients in alert hospital, Ethiopia
Mairie Guizaw Kebede, Saint George dermatology clinic, Ethiopia
Background: Leishmania aethiopica is a peculiar parasite causing cutaneous leishmaniasis in Ethiopia and its mainstay treatment is Sodium Stibogluconate. However its treatment outcome in Ethiopia is not well documented. Objectives: To determine the treatment outcome of a [....] » Read More
Title : Molecular screening for intestinal protozoan and fungal pathogens and first subtyping of blastocystis spp. in hemodialysis patients in Slovakia
Elena Hatalova, Pavol Jozef Safarik University, Slovakia (Slovak Republic)
Blastocystis spp., Cryptosporidium spp., Giardia intestinalis and Microsporidia spp. are protozoan and fungal intestinal pathogens in immunocompromised individuals, causing symptomatic or asymptomatic infections, which are usually undiagnosed. Uremia in hemodialysis patients with [....] » Read More
Title : Identification of novel P. falciparum Kelch13 (PfK13) interacting partners via coimmunoprecipitation (co-IP)
Preeti Chaudhary, ICMR-National Institute of Malaria Research, India
Malaria remains a global health issue affecting half of the world's population. The current treatment regimen which includes artemisinin and other combination therapies is being threatened with the rapid emergence of resistance. P. falciparum under drug pressure has revealed [....] » Read More
Title : Investigation of the immunomodulatory effects of cecropin A on a primary hepatic coculture of chicken origin
Rege Anna Marton, University of Veterinary Medicine, Hungary
The indiscriminate use of conventional antibiotics has contributed to the global spread of antibiotic resistance, therefore, there is an urgent demand to search for alternatives that can provide a novel antimicrobial mode of action. Finding a potential replacement is crucial for [....] » Read More
Title : Characterisation of the proteomic response of candida parapsilosis to the silver(I) compound SBC3
Magdalena Piatek, Maynooth University, Ireland
The antimicrobial activity of silver has long been established and is widely used clinically. The low toxicity and broad-spectrum activity of silver make it a promising candidate in the fight against resistant pathogens. N-heterocyclic carbenes (NHCs) constitute a versatile range [....] » Read More
Title : Progression of pneumococcal nasopharynx colonization in relation to the pneumococcal conjugate vaccines in children between the ages of 2 months to 5 years at boston medical center
Tafaani Khan, Department of Pediatric Infectious Diseases at Boston Medical Center , United States
The Nasopharyngeal Surveillance Study clinically investigates the progression of Streptococcus pneumoniae (SP) nasopharynx (NP) colonization in relation to the Pneumococcal Conjugate Vaccines, specifically 7-Valent Pneumococcal Conjugate Vaccine, 13-Valent Pneumococcal Conjugate [....] » Read More
Title : The role of aedes koreicus in the circulation of dirofilaria repens and dirofilaria immitis filarial nematodes in a middle-sized european city, in Hungary
Zsaklin Varga, University of Pecs, Hungary
The mosquito-borne pathogens are present worldwide, notable among these are Dirofilaria immitis, which causes heartworm disease, and Dirofilaria repens, known as the causative agent of subcutaneous dirofilariasis. These two species are unfortunately endemic throughout Europe and [....] » Read More
Title : Frequency of rotavirus infection among vaccinated and non-vaccinated children with diarrhea in omdurman pediatric hospital, Sudan
Alaaeldeen Balal Ahmed, Omdurman Islamic University, Sudan
Background: Rotavirus infection is the most common cause of severe diarrhea in young children and infants worldwide. Epidemiological knowledge concerning rotaviruses among infants and children is critical for the development of effective measures, including vaccines. Meth [....] » Read More
Title : Development of a syndromic molecular diagnostic assay, using barcoded magnetic bead technology for tick-borne pathogens
Sheema Mir, Western University of Health Sciences, United States
The infectious disease diagnostics often depends on costly serological testing with poor sensitivity, low specificity, and long turnaround time. Here In this manuscript, we demonstrate the proof of the principle for simultaneous detection of two tickborne pathogens from a single [....] » Read More