Robin Mac Diarmid, University of Auckland , New Zealand
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Neonatal microcephaly and adult Guillain-Barré syndrome are severe complications of Zika virus (ZIKV) infection. The robustly induced inflammatory cytokine expressions in ZIKV-infected patients may constitute a hallmark for severe disease. One of them is the high mobility [....] » Read More
With all the advances in medicine and medical treatments, MDR bacteria remains one of the greatest threats in healthcare systems. The rates of AMR (antimicrobial resistance) organisms continues to increase globally despite the efforts to combat. WHO has declared that AMR is one o [....] » Read More
In order to contribute to the understanding of the mechanism of invasion of epithelial cells by Shigella sp., we have first shown (i) Shigella strains as well as clinical or environmental strains are able to secrete biosurfactant-like molecules (BLM) directly [....] » Read More
Background and Purpose: Rabies virus is a fatal infectious disease in the mammalian host including humans, carnivores, and livestock which imposes a huge burden on the health of the community and the global economy. The development of new rabies vaccines is a criti [....] » Read More
Aedes aegypti is the most important vector of at least four fatal and/or debilitating arboviruses (dengue, chikungunya, yellow fever and Zika). Insecticide-based approaches remain the major intervention to minimize vector-borne disease burden across the diseases. In Brazil [....] » Read More
Objectives: Although several studies have shown that the application of antimicrobial stewardship (AMS) has a positive impact on reduction of antimicrobial resistance and therefore the clinical outcomes of patients, most of the studies were conducted some years ago, and [....] » Read More
Since launching in September 2020, the Infection Innovation Consortium (iiCON) lead by the Liverpool School of Tropical Medicine has established itself as a leading global centre for infectious disease R&D. Founded with an £18.6 million investment from UK Government, [....] » Read More
Soon after SARS-CoV-2 was recognised as a pandemic threat, we set out to pioneer technologies to fast-track and de-risk advanced drug development. Our highly innovative models offers industry access to pioneering technologies which support the development of game-changing nove [....] » Read More
Zika virus (ZIKV) is a re-emerging flavivirus that poses a significant public health threat. ZIKV exhibits a wide array of non-vector borne human transmission routes, such as sexual transmission, transplacental transmission and blood transfusion. Detection and surveillance of ZIK [....] » Read More
Difficult-to-treat infections have led to a renewed interest in phage therapy as adjunct to conventional surgical and antimicrobials treatments. Chronic bone infections are biofilm-related infections difficult to eradicate; in vitro data indicate that phages are active against bi [....] » Read More
The severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic is a major health concern affecting socio-economic lives. As with other highly contagious diseases, it is of utmost importance to identify and treat the healthy carriers or positive asymptomatic subjects (P [....] » Read More
Background: This study was designed to evaluate the efficacy and safety of nebulized ethanol (EtOH) in the treatment of COVID-19. Methods: A RCT of 99 symptomatic and RT-PCR-positive patients admitted to a hospital receiving Remdesevir-Dexamethasone was conducted. They were ra [....] » Read More
Background: In COVID-19 a dysregulated immune response and cytokine storm is the underlying mechanism that determines the adverse outcome. The Neutrophil/Lymphocyte Ratio(NLR) and Platelet/Lymphocyte Ratio(PLR) have been considered as systemic inflammatory response markers. O [....] » Read More
Background: Adherence to antiretroviral therapy (ART) reduces morbidity and mortality among people living with HIV (PLHIV) by suppression of viral replication, restoration and preservation of immune function. However, poor adherence with ART may lead to treatment failure and dea [....] » Read More
Introduction Coronavirus disease 2019 (COVID-19) caused by the virus SARS-CoV-2 is an ongoing global pandemic which led to loss of human life worldwide and presents an unprecedented challenge not only to public health but also to the food systems and the world of work.1 In the P [....] » Read More
Candida duobushaemulonii is a yeast that belongs to the Candida haemulonii species complex. Similar to Candida auris which is an emerging global health threat, C. duobushaemulonii is a major concern in the healthcare system as it is often multidrug resistant. Prese [....] » Read More
Rhabdomyolysis is a life-threatening disorder that manifests with myalgia, fatigue, and pigmenturia, with a mortality rate as high as 59%. Acute renal failure which occurs in 13-50% of cases. Myalgia and fatigue are common constitutional symptoms in patients with viral infection [....] » Read More
Background: Cryptococcal meningitis (CM) is associated with high mortality. The relation between antifungal susceptibility and treatment outcomes is not well characterized. There is paucity of surveillance data of cerebrospinal fluid (CSF) isolates of cryptococcus investigated wi [....] » Read More
Objective; to demonstrate the antibiotic usage and trends among pediatric patient admitted in tertiary care hospital of rawalpindi Study Design; Analytical cross sectional study Place and Duration of Study: pediatric in patient department of two tertiary care hospitals of R [....] » Read More
Objectives To study the burden, clinical and laboratory features and outcome of Human Parechoviruses (HPeVs) infection among children managed at a tertiary hospital in Oman. Methods: This is a retrospective study of children (< 18 years of age) with molecular proven HPeV in [....] » Read More
Introduction COVID-19 vaccines are administered to protect populations from SARS-CoV-2 infections. Even in case of breakthrough infections, current vaccines protect people against severe outcomes, that is, acute illness, hospitalization, and fatality. Prevention of patients fr [....] » Read More
Background: Women of childbearing age are commonly affected by bacterial vaginosis (BV). Maternal-fetal outcomes associated with BV during pregnancy can be fatal for both the mother and the newborn. In this review, we aim to identify maternal and fetal outcomes in pregnant women [....] » Read More
Twenty diseases are recognized as neglected tropical diseases (NTDs) by World Health Assembly resolutions, including human filarial diseases. The end of NTDs is embedded within the Sustainable Development Goals for 2030, under target 3.3. Onchocerciasis afflicts approximately 20. [....] » Read More
BACKGROUND: Coronavirus disease 2019 (COVID-19) is an acute, highly transmissible infectious disease. SARS-CoV-2 is the causative agent and is associated with a cytokine storm characterized by increased plasma concentrations of IL-2, 6, and 10. INF-α2 has been reported to [....] » Read More
The poor diagnostic and prognostic potential of existing tools potentially hinder the tuberculosis (TB) prevention and control program. Currently, antigen-specific blood-based biomarkers have become alternatives to improve the diagnostic and prognostic challenges related to tuber [....] » Read More
Rapid and accurate visceral leishmaniasis (VL) diagnosis is needed to initiate prompt treatment to reduce morbidity and mortality. Here, we evaluated the performance of loop-mediated isothermal amplification (LAMP) assay for the diagnosis of VL from blood in an endemic area in Et [....] » Read More
Background: High TB mortality is increasingly understood as an indicator of different problems in the health system and community. Limited awareness of TB in the community, restricted accessibility and/or quality of health services can hamper survival. Exploration and analysis of [....] » Read More
Leishmaniasis is one of the most neglected tropical diseases (NTDs), caused by a parasite of the genus Leishmania which is transmitted through a sand-fly vector and mostly affects the poorest of the poor. It is characterized by physiological and clinical manifestations of lesions [....] » Read More
BACKGROUND: The proposed study will characterise the genomes of multi-drug resistant hospital-acquired invasive Acinetobacter baumannii (A. baumannii) which overwhelmingly contributes to neonatal deaths, particularly in low-middle income countries (LMICs) where the burden of [....] » Read More
Background Nepal has achieved and sustained elimination of leprosy as a public health problem since 2009, but 17 districts and 3 provinces have yet to eliminate the disease. Pediatric cases and grade-2 disabilities (G2D) indicate recent transmission and late diagnosis respectiv [....] » Read More
Acute encephalitis syndrome (AES) is defined as acute onset of fever and a change in mental status (including symptoms such as confusion, disorientation, coma or inability to talk) and/or new onset of seizures (excluding simple febrile seizures) in a person of any age at any time [....] » Read More
Objectives: Development of pleural form of tuberculosis is still poorly understood, particularly in quite high-endemic countries like Morocco. Genotypic studies may help understanding the transmission routes of Mycobacterium tuberculosis strains in pleural TB patients. Materi [....] » Read More
Many historical epidemics have been associated with natural or manmade disasters. Military events cause the spread of infections. This has been known for thousands of years. There are many scientific papers that emphasize the need for early action on the center of possible spread [....] » Read More
Introduction: The main causative agent of Tetanus infection is the bacterium Clostridium tetani, a gram-positive, spore-former obligate anaerobic microorganism. It continues to be an important public health concern in developing countries like the Philippines, even though it is p [....] » Read More
Introduction: Chromoblastomycosis is a chronic subcutaneous fungal infection characterized by the presence of muriform cells commonly diagnosed among countries in tropical and subtropical regions like Africa, Latin America, India, China, Japan, Malaysia and Austral [....] » Read More
Introduction: Dengue fever is a significant cause of morbidity throughout the world caused by the dengue virus (DENV). Four antigenically different dengue virus serotypes (DENV-1,2,3, and 4) are known to cause infections in humans (Halsey,2012). Chances for developing dengue hem [....] » Read More
Background: Multisystem Inflammatory Syndrome (MIS) is a rare form of COVID-19 affecting multiple extrapulmonary organ systems without severe respiratory illness. It is primarily seen in children under 21 years of age but with similar but rare syndrome in adults that may require [....] » Read More
Short Introduction: Drug repurposing is an alternative avenue for identifying new drugs to treat tuberculosis (TB). Although TB can be cured with anti-tubercular drugs, the emergence of multidrug-resistant and extensively drug-resistant strains of Mycobacterium tuberculos [....] » Read More
BACKGROUND AND AIM: Tuberculosis is known to mimic several condition, especially malignancy. Pulmonary TB can present with pulmonary infiltration with or without mediastinal lymphadenopathy. TB often gets misdiagnosed in the countries having low incidence of TB with high incidenc [....] » Read More
Aim of study: Group B streptococcus (GBS) is a leading cause of invasive infection among neonates and infants worldwide, with two described syndromes, early onset GBS (EOGBS) disease and late onset GBS (LOGBS) disease. In our study, we investigated the incidence of invasive GBS [....] » Read More
Background: Contact tracing (CT) can support Ebola Virus Disease (EVD) outbreak control, but its effectiveness depends on rapid identification and regular, close monitoring of contacts. Ideally, all new cases should be previously-known contacts and spend minimal time ill in the c [....] » Read More
The last 2 years after breakout of Covid pandemic there have been reported and published skin integrity complications mostly in critical care departments covid infected patients. International literature highlights the spread per 57% of facial pressure ulcer development, as conse [....] » Read More
Background: Even though respiratory viruses are one of the most common triggers for asthma exacerbations, not all of these viruses affect patients equally. Objective: To assess the prevalence of covid19 infection in patients presented with acute exacerbation of asthma, C [....] » Read More
Background: Monkeypox was declared as a global health emergency by the World Health Organisation. Most reported cases disproportionately involved, but were not limited to, men who have sex with men (MSM). Given the epidemiological risk of infection within the MSM community, this [....] » Read More
Background: Nigeria accounts for 25% of Neglected Tropical Disease (NTDs) burden. The disease tends to impact negatively on wellbeing and productivity. Efforts via health expenditure for NTDs programme have not improved health outcomes. The study examines long-run relationship b [....] » Read More
Background: Insects always play an important role in the global ecosystem. Several hypotheses and studies were conducted emphasizing their role in transmitting or spreading the virus in the environment. Among insects, flies are the most common and anthropophilic insects in the w [....] » Read More
Background: Mortality of tetanus infection is directly proportional to the severity of infection. Tetanus is a preventable yet very fatal disease due to its autonomic dysfunction, muscle spasms, and rigidity. Aggressive intervention is necessary in order to manage the Tetanus in [....] » Read More
Introduction: Febrile neutropenia is a major cause of morbidity and mortality in children with hematologic malignancies. It presents as a serious, potentially fatal condition complicating cancer treatment associated with significant morbidity and mortality. To date, established n [....] » Read More
Toll/interleukin-1 like receptors (TLRs) are membrane-spanning proteins crucially involved in innate immunity. On activation, the cytoplasmic toll/interleukin-1 receptor (TIR) domains of these receptors undergo homo- or heterodimerization. Brucella sp. are bacterial pathogens tha [....] » Read More
Background: CoNS, a major commensal of skin, now a notable cause of nosocomial infections, especially in patients undergoing surgical procedures. In previous decades, the β-lactams, most efficient weapons to control CoNS infection, have now blunted progressively. CoNS have [....] » Read More
Attitude and Hesitancy toward COVID-19 vaccine in a Pakistani population 2021 Objective: The objective of this study was to find out how the people show their attitude toward vaccine against COVID-19 in a Pakistani Population. Materials and methods: Retrospective coho [....] » Read More
Background: Acute meningitis is an inflammation of the tissue surrounding the brain, commonly caused by viruses and bacteria. The typical clinical manifestations of acute meningitis include fever, headache, neck stiffness and change in mental status 5,8. The diagnosis is made by [....] » Read More
Invasive mycoses are linked to higher mortality and morbidity (1). Most of these infections are hospital acquired, frequent in intensive care units and account approximately for 15% of healthcare related infections (1, 2). The aim of this paper is to analyse available data on hea [....] » Read More
Introduction: Moniquira is a small town in Colombia, with 20,800 inhabitants. The main economic activity is agriculture. Leptospirosis is a zoonotic disease related with contaminated water, animals, and poverty. The aim of this paper is to describe the clinical course of the dise [....] » Read More
Introduction In Odessa, the police detained three people who thought they were sick COVID-19 and tried to infect others intentionally spit on the front door handles, on the handles of cars parked near shops, on the railing in the entrances of multi-storey buildings. This w [....] » Read More
After a period of two seasons of absence (2020/2021) or low prevalence (2021/2022) of influenza viruses, the 2022-2023 season was characterized by high influenza activity in Bulgaria. The objectives of this study were to analyze the pattern of influenza virus circulation with res [....] » Read More
The problems of infections transmitted by sucking a tick are due to the expansion of the distribution area of ticks and an increase in the incidence of tick-borne infections. Farm animals that make up the agrobiodiversity of Uzbekistan are at risk of disease with numerous pathoge [....] » Read More
Background: Hospital Acquired Pneumonia is an important public health concern. Even with the advent of new anti-bacterials, there is an increasing prevalence of anti-microbial resistance worldwide. In particular, Ventilator Acquired Pneumonia can increase mortality risk in patie [....] » Read More
Introduction: Tularemia is an uncommon disease. An average of 173 cases per year were reported in the US for the past 20 years.(1) A low minimal-infective-dose, high rate of dissemination and the possible mortality make tularemia a potential weapon for bioterrorism.(2) This repo [....] » Read More
BACKGROUND: Nasal cavity tuberculosis is rare, but it can be caused by either a pulmonary disease or retrograde involvement of the nose by lupus vulgaris of the facial skin. Here we are going to present a rare case of nasal cavity tuberculosis. PRESENTATION AND MANAGE [....] » Read More
Background In December 2019, the coronavirus disease 2019 (COVID-19) first became identified in the market places of Wuhan, China. The first incidence of COVID-19 was identified in Saudi Arabia on March 2, 2020, and then within a month, the total number of reported instances ha [....] » Read More
Purpose: To evaluate the value of modified Brixia scoring system in predicting mortality in hospitalized COVID-19 patients. Methods and materials: An observational retrospective pilot study included 292 patients (178 male and 114 female) with PCR-confirmed COVID-19 infection h [....] » Read More
Introduction: Protozoa are unicellular and eukaryotic microorganisms. Despite the simple cellular structure, it can destroy the hosts bodies during its parasitic life, especially when this life contain symbiosis with one or more other microorganisms. Protozoa have received less a [....] » Read More
Title : Novel nasal formulations containing EC16 to combat long COVID
Stephen Hsu, Augusta University, United States
Background: Severe Acute Respiratory Syndrome (SARS) coronavirus 2 (SARS-CoV-2) is responsible for the 2019 coronavirus epidemic (COVID-19). SARS-CoV-2 infection is associated with high mortality and morbidity worldwide. By Dec 1, 2022, over 643 million cases have been reported w [....] » Read More
Title : MVA-based virotherapies in the treatment of infectious diseases
Inchauspe Genevieve, ImmunResQ Department, Transgene, France
A famous milestone in the vaccine field has been the first successful vaccination against smallpox in 1798 by Edward Jenner. Using the vaccinia cowpox virus, Jenner was able to protect vaccinees from variola or smallpox. The Modified Virus Ankara (MVA) poxvirus strain has been on [....] » Read More
Title : Selection underlying evolution and spread of SARS-CoV-2 variants
Ranjan Ramasamy, IDFISH Technology, United States
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious RNA virus that was first identified in December 2019 in Wuhan, China. It is the pathogen responsible for the present coronavirus disease 2019 (COVID-19) pandemic. A large number of genetic var [....] » Read More
Title : Essential functions of RNA virus genome beyond the storage of protein-coding information
Alfredo Berzal-Herranz, Instituto de Parasitologia y Biomedicina “Lopez-Neyra”, (IPBLN) CSIC, Spain
RNA viruses are a major threat to the human health. They are responsible for infections with high morbidity and mortality rates and an extraordinary socioeconomic burden. In the last decades, different RNA viruses have produced major outbreaks against which there were no efficien [....] » Read More
Title : The role of novel cold atmospheric plasma technology in preventing infectious diseases
Chunyang Li, Jiangsu Academy of Agricultural Sciences, China
Infectious diseases are becoming a health burden, causing numerous hospitalisation cases and deaths and leading to global economic losses. The prevention and control of infectious diseases have become more important as a result of the COVID-19 pandemic. Traditional disinfection m [....] » Read More
Title : Seroprevalence of cross-reactive anti-SARS-CoV-2 antibodies in pre-COVID-19 samples collected from cameroonian women during pregnancy and at delivery
Seumko o Ndeumou Medouen Reine, University of YaoundeI-Cameroon, Cameroon
Background: The COVID-19 Pandemic still causes significant morbidity and mortality worldwide. Significantly more cases of COVID-19 and its related deaths are reported in High-Income countries compared to Low- and Middle-Income Countries (LMIC). This might be due to pre-exist [....] » Read More
Title : SARS-CoV-2 lineage identification from massive parallel sequencing data: An analytical workflow
Valeria Di Lollo, Istituto Zooprofilattico Sperimentale (IZS), Italy
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of the ongoing outbreak of the disease known as coronavirus disease 2019 (COVID-19). The genetic plasticity of SARS-CoV-2 has determined the emergence of numerous variants with enhanced adaptive c [....] » Read More
Title : Inflammatory markers and hematologic indices in the prediction of severity of COVID-19: A single center study in southern philippines
Meccar Moniem H. Elino, Southern Philippines Medical Center, Philippines
Background: Various diagnostic tests across COVID-19 literatures were employed as surrogate markers in COVID-19, wherein interleukin-6 (IL-6) – gauge for cytokine storm or impending severity – is not readily available among the third world countries particularly the P [....] » Read More
Title : Point prevalence survey of antimicrobial use in a tertiary training hospital in Zamboanga City, Philippines, 2022
Sebar Sala, Zamboanga City Medical Center, Philippines
Background: The increasing prevalence of infections due to Antimicrobial Resistance (AMR) constitutes a serious threat to healthcare systems. This study investigated the trends and compliance to antimicrobial prescribing to identify potential areas for quality improvement. Met [....] » Read More
Title : Prevalence, clinical features and outcomes of hepatitis b and hepatitis c co-infections among HIV-positive adults in a philippine tertiary hospital from january 2015 to december 2019
Maria Luisa R. Maranan, San Lazaro Hospital, Philippines
Introduction: The Philippines is one of the countries with the fastest rising growth rate of HIV in the Asia Pacific. HIV, HBV and HCV have similarities in terms of risk factors and transmission routes, hence co-infection with HBV and/or HCV are said to be common in HIV-positive [....] » Read More
Title : First molecular identification of mermithid nematodes (Nematoda: Mermithidae) infecting Culicoides spp (Diptera: Ceratopogonidae) in Tunisia
Darine Slama, University of Monastir, Tunisia
The Mermithid nematode parasitizes many biting midges worldwide, causing changes in different parts of their body, especially intersexes phenomena. In Tunisia, and to our knowledge any study was recorded to know if this phenomenon exists and to identify the nematode species invol [....] » Read More
Title : Camels as one health bio-indicators: Example of vector borne pathogens
Selmi Rachid, Rachid, Tunisia
Livestock constitute habitual hosts and carriers for several infectious pathogens which may represent a serious public health concern and lead to a wide economic losses. Camels are increasingly the subject of several scientific investigations, showing that they are receptive and [....] » Read More
Title : Effects of the natural compound on SARS-CoV-2 spike protein-mediated metabolic alteration in THP-1 cells explored by the 1H-NMR-based metabolomics approach
Gyaltsen Dakpa, National Chung-Hsing University, Taiwan
A change in metabolism is one of the hallmarks of coronavirus disease 2019 (COVID-19) that cause severity and mortality. The mechanism of SARS-CoV-2 spike protein-mediated perturbations of metabolic pathways and modulation of antcin A, a steroid-like compound isolated from Taiwan [....] » Read More
Title : Endogenous sex hormone levels and risk of ischemic stroke: A systematic review and meta-analysis
Pradeep Kumar, AII India Institute of Medical Sciences, India
Background and aims: Ischemic stroke (IS) causes significant mortality worldwide and has higher incidence among men than women. In this study, we investigated the risk-association of endogenous sex hormones in males and females with ischemic stroke. Methods: Comprehensive lite [....] » Read More
Title : Facilitators and challenges for integrating campaigns for control of neglected tropical diseases in North India
Preetha G S, International Institute of Health Management Research, India
Integrated health campaigns with multiple interventions can potentially lead to improved population coverage, service delivery, quality assurance and time efficiencies. We conducted a study in Uttar Pradesh where disease control campaigns are held routinely to achieve national he [....] » Read More
Title : Increase access to Mental Health Care ( MHC) services and HIV/AIDS awareness, testing and support among the Young LGBTQ+ community through use of social media in Mityana city
Ssembatya Benard, Vijana Na Children Foundation, Uganda
Introduction: Research shows that young LGBTQ+ community in Mityana City have less access to MHC services and HIV information, testing and support thereby being at a risk of HIV infections. Vijana Na Children Foundation-Uganda (VINACEF) used social media to provide access [....] » Read More
Title : Comparison the immune response of FMD vaccine developed using different adjuvants in mice.
Tedros, Comsats University, Eritrea
Ethiopia is thought to have the most significant livestock population in Africa. The appearance of contagious diseases can excessively hinder economic development .Foot and mouth disease occurs throughout the country, with the highest incidence reported in central Ethiopia. Foot- [....] » Read More
Title : Phenolic, antioxidant quantification and NMR analysis of Moringa oleifera L. plant extracts
Zimasa Busisiwe Dubeni, University of Fort Hare, South Africa
Moringaceae, one of the most prominent plant families, includes species with high economic, ecological, and medicinal importance because of their potent phytochemicals. M. oleifera, commonly known as Horse radish is a small, fast, growing, evergreen, deciduous tree. It is among t [....] » Read More
Title : Frequency of active cough among paragonimiasis patients in coastal communities in Calabar, Nigeria
Emmanuel Chukwunenye Uttah, University of Agriculture & Environmental Sciences, Nigeria
This study was aimed at investigating the epidemiology of paragonimiasis in two selected coastal communities in Calabar suburb, namely Akpabuyo and Calabar South. Seven sputum examinations per person were carried out for the presence of Paragonimus uterobilateralis eggs/ova. Poss [....] » Read More
Title : High prevalence of cryptosporidium infection in patients suffering from colorectal cancer
Hossein Mahmoudvand, Lorestan University of Medical Sciences, Iran (Islamic Republic of)
The present investigation was designed to study the prevalence of cryptosporidiosis in the colorectal cancer patients compared to the healthy subjects. The present descriptive case-control study was performed on 174 subjects including 87 healthy people and 87 patients with colore [....] » Read More
Title : Software product for clinical and immunological prognosis of the severity of covid-19
Nodirjon Ruzimurodov, Institute of Immunology and human genomics, Uzbekistan
One of the global problems at the moment is the Coronavirus (COVID-19). Everyone already knows all the consequences of COVID-19. In addition, determining the course of the severity of the disease is also an important factor for both the patient and the medical staff. Until now, t [....] » Read More
Title : Determinants of early virologic failure among hiv patients on first-line anti-retroviral therapy
Diana Gonzaga Ramos, Research Institute for Tropical Medicine, Philippines
Background: The initiation of anti-retroviral therapy (ART) effectively restores immune function and reduces HIV-related morbidity and mortality. However, virologic failure while on ART may lead to increased morbidity and compromised quality of life. The aim of this study was to [....] » Read More
Title : Clinical profile and outcome of adult covid-19 patients treated with remdesivir in a tertiary infectious disease hospital in manila, philippines: retrospective cohort study
Kevin Cham A. Bueno, San Lazaro Hospital, Philippines
Background: Multiple therapeutic agents have been demonstrated to provide benefits against COVID-19. Clinical trials which evaluated remdesivir for SARS-CoV-2 infection had shown efficacy in disease recovery and mortality and it is of equal importance to determine the onset of tr [....] » Read More
Title : Procalcitonin as a predictor of mortality among patients admitted with pulmonary tuberculosis and community acquired pneumonia in a tertiary referral hospital for infectious disease
Abegail b. Latawan-danasen, San Lazaro Hospital, Philippines
Pulmonary tuberculosis is a worldwide global health burden. According to the WHO guidelines on tuberculosis infection prevention and control that was updated last 2019, tuberculosis accounts for more than 10million cases per year and the deaths caused by Tuberculosis alone accoun [....] » Read More
Title : Bacterial co-infection and secondary infection in Sars-Cov-2 (Covid- 19) adult patients in a national tertiary infectious disease hospital
Maria Yvez Erika P. Ugale, San Lazaro Hospital, Philippines
Introduction: The SARS-CoV-2 virus, the main causative agent of COVID 19 infection was first detected in the province of Hubei in Wuhan China in December of 2019 and has overwhelmed the capacity of the government and hospitals to provide healthcare services to cater to the growin [....] » Read More
Title : Concept elicitation, cognitive debriefing and usability testing of COVID symptoms diary
Susan M Dallabrida, SPRIM US LLC, United States
Objective: COVID-19, caused by a coronavirus, SARS-CoV-2, has been the cause of the global pandemic from 2020-2022. Due to COVID-19’s novelty, there exist no validated patient reported outcome (PRO) tools that allow for proper evaluation of patient infection severity based [....] » Read More
Title : Calcium-dependent restriction of HIV-1 by S100A9 in myeloid cells
Hertel Quentin, University of Montpellier, France
The alarmin S100A9 is a calcium-binding protein known for its pro-inflammatory extracellular role in the immune response against pathogens in the form of a S100A8/S100A9 heterodimer called calprotectin. However, S100A9 was recently shown to exert an intracellular antiviral effect [....] » Read More
Title : Are water buffaloes susceptible to lumpy skin disease? A pilot study
Elisabetta Di Felice, Experimental Zooprophylactic Institute of Abruzzo and Molise Giuseppe Caporale, Italy
Lumpy skin disease (LSD) is a viral disease of cattle and water buffalo characterized by cutaneous nodules, biphasic fever, oral and nasal discharge, accompanied by general lymphadenitis. Clinical infections in cattle range from sub-clinical to acute form and the disease is assoc [....] » Read More
Title : Potential sars-cov-2 susceptibility of cetaceans stranded along the italian coastline
Tania Audino, Istituto Zooprofilattico Sperimentale di Piemonte, Italy
Due to marine mammals’ demonstrated susceptibility to SARS-CoV-2, based upon the homology level of their angiotensin-converting enzyme 2 (ACE2) viral receptor with the human one, alongside the global SARS-CoV-2 occurrence and faecal contamination of the river and marine eco [....] » Read More
Title : A clinical profile of side effects of covid-19 pfizer-biontech mrna vaccine among children aged 12-18 years old in metro manila
Emelia Katrina I. Cafugauan, St. Lukes Medical Center, Philippines
Reluctance to COVID 19 vaccination that is secondary to limited knowledge on side effects, reporting of serious adverse reactions and emergency use of the vaccine is a major problem that could hinder achieving herd immunity against COVID 19 infection. Continuous monitoring and re [....] » Read More
Title : The association of cycle threshold value with disease severity and biochemical outcomes among pediatric patients with rt-pcr confirmed covid-19 infection seen in a tertiary hospital
Maria Luz Isadora L. Timbancaya, St. Luke’s Medical Center, Philippines
Background. The gold standard in the diagnosis of COVID-19 infection remains to be through RT-PCR. This is done through the determination of a cycle threshold value. There have been conflicting studies as to whether the cycle threshold value can also be used to determine disease [....] » Read More
Title : Clinical outcomes of neonates born to Covid-19 positive mothers in a tertiary level private hospital
Patricia Abigail B. Miranda, St. Luke’s Medical Center, Philippines
COVID-19 infection is a novel viral illness which began as a local epidemic in December 2019 at Wuhan, China which quickly emerged into a pandemic by February 2020. The virus causes a spectrum of signs and symptoms, ranging from mild upper respiratory symptoms to acute respirator [....] » Read More
Title : Profile of beta-lactamases in multidrug-resistant (MDR) acinetobacter baumannii strains in lithuania 2016-2017 and 2021-2022 years
Kristina Cerniauskiene, Lithuanian University of Health Science, Lithuania
Introduction: Acinetobacter baumannii (A. baumannii) is an important nosocomial pathogen that possesses not only intrinsic resistance to many classes of antibiotics, but also has a propensity for rapid development of antimicrobial resistance during treatment. Aims & O [....] » Read More
Title : Tuberculosis meningoencephalitis and drug side effects : the important role of early diagnosis and therapy modification for better outcome in indonesia
Ratna Ayu Cahaya Kusuma Dewi, Diponegoro University, Indonesia
Background Tuberculous (TB) meningoencephalitis is a major global health problem and the most severe form of extrapulmonary TB with high mortality rate. In case Mycobacterium tuberculosis (MTB) is suspected as the etiology, early diagnosis and treatment with anti-tuberculosis dr [....] » Read More
Title : Co-infection of severe leptospirosis and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with multiple organ involvement in indonesia
Elfian Rachmawati, Diponegoro University, Indonesia
Leptospirosis co-infection and the pathogenesis of SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) play a significant part in the emergence and progression of SARS-CoV-2 infection by enhancing the difficulty of identification, management, and outcome of COVID-19 well [....] » Read More
Title : Culture-proven bloodstream infection in children managed at a tertiary hospital in oman
Marwah Saud Al-Thuhli, Oman Medical specialty Board, Oman
Objectives: Bloodstream infection (BSI) in children causes significant morbidity and mortality and is associated with longer hospital stays and higher healthcare costs. Our objective is to study the incidence and risk factors and identify causative organisms and outcomes of BSI a [....] » Read More
Title : SARS CoV2 viral load and replication in postmortem pulmonary and extrapulmonary tissues
Cintia Cevallos, University of Buenos Aires INBIRS, Argentina
Background. The novel coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2 is severe and involves multiple organs in approximately 5%-10% of patients, leading to multi-organ dysfunction and failure. Methods. Necropsy tissues (lungs, heart, liver, kidney, small-intestine) we [....] » Read More
Title : Survillance of dengue vectors; what has been done by health system in southeastern iran?
Jalil Nejati, Zahedan University of Medical Sciences, Iran (Islamic Republic of)
Nowadays, the rapid expansion of dengue fever vectors, Aedes albopictus and Ae.aegypti, around the globe has been warned by various documents. In recent years, the eastern neighbor of Iran, Pakistan, has been involved with dengue outbreaks, and the risk of the entrance of t [....] » Read More