Difficult-to-treat infections have led to a renewed interest in phage therapy as adjunct to conventional surgical and antimicrobials treatments. Chronic bone infections are biofilm-related infections difficult to eradicate; in vitro data indicate that phages are active against bi [....] » Read More
RNA viruses are a major threat to the human health. They are responsible for infections with high morbidity and mortality rates and an extraordinary socioeconomic burden. In the last decades, different RNA viruses have produced major outbreaks against which there were no efficien [....] » Read More
Background: New antiviral agents for COVID-19, including molnupiravir for the oral treatment and sotrovimab as the monoclonal antibody for the intravenous treatment are currently authorized and available in addition to remdesivir for the intravenous treatment in Japan. Method [....] » Read More
Historically, testing for antibodies to infectious diseases was performed using biological assays such as haemagglutination inhibition or complement fixation. In recent times, this testing has moved to binding assays, firstly microtitre plate enzyme immunoassays and then to [....] » Read More
Historically, testing for antibodies to infectious diseases was performed using biological assays such as haemagglutination inhibition or complement fixation. In recent times, this testing has moved to binding assays, firstly microtitre plate enzyme immunoassays and then to [....] » Read More
Diseases of microbial aetiology of economic significance have surfaced in the aquaculture sector leading to high mortality and economic losses for farmers. Various environmentfriendly remedial measures have been taken up as an alternative to antibiotics to control microbial disea [....] » Read More
Infectious diseases are becoming a health burden, causing numerous hospitalisation cases and deaths and leading to global economic losses. The prevention and control of infectious diseases have become more important as a result of the COVID-19 pandemic. Traditional disinfection m [....] » Read More
Bacterial infections in the genital tract are one of the causes of female infertility worldwide with a prevalence rate of 30–40 %. Infertility in these cases is generally recognized as a consequence of inflammation. Bacteria may lead to inflammation due to the presence of L [....] » Read More
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious RNA virus that was first identified in December 2019 in Wuhan, China. It is the pathogen responsible for the present coronavirus disease 2019 (COVID-19) pandemic. A large number of genetic var [....] » Read More
Background: Severe Acute Respiratory Syndrome (SARS) coronavirus 2 (SARS-CoV-2) is responsible for the 2019 coronavirus epidemic (COVID-19). SARS-CoV-2 infection is associated with high mortality and morbidity worldwide. By Dec 1, 2022, over 643 million cases have been reported w [....] » Read More
Virus infection causes various types of diseases in humans, and the innate immune responses serve as the first line of defense against viruses. Virus infection causes rapid induction of antiviral and inflammatory genes in the infected cells, leading to the establishment of an ant [....] » Read More
Background: Despite children and young people (CYP) having a low risk for severe COVID-19 outcomes, there is still a degree of uncertainty related to their risk in the context of immunodeficiency or immunosuppression, primarily due to significant reporting bias in most studies, a [....] » Read More
Early during 2020 COVID-19 pandemics the proportion of children vs. adults positive for SARS-CoV-2 in a RT-PCR test was shown to be lower in different countries. This suggested that children are more resistant to the novel infection than adults. Here we show that in Warsaw, Polan [....] » Read More
Introduction: Coronavirus disease 2019 (COVID-19) has become the most devastating public health issue in the entire world. The disease has been spreading internationally and has swept the world in a short period. It stated as a pandemic by the World Health Organization on March [....] » Read More
The COVID-19 pandemic has led to an increased interest in the study of IgY (Immunoglobulin Y) as a potential inhibitor of SARS-CoV-2, the causative agent of COVID-19. IgY is a type of antibody found in birds, and reptiles, and it is similar in structure and function to the mammal [....] » Read More
Background Coronavirus disease 19 (COVID-19) pandemic has posed a challenge to the health sector, and frontline healthcare workers (HCWs) are at higher risk of getting the infection. However, there is a scarcity of data on vaccination and post-vaccine breakthrough infections i [....] » Read More
Leptospirosis co-infection and the pathogenesis of SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) play a significant part in the emergence and progression of SARS-CoV-2 infection by enhancing the difficulty of identification, management, and outcome of COVID-19 well [....] » Read More
Background: Adherence to antiretroviral therapy (ART) reduces morbidity and mortality among people living with HIV (PLHIV) by suppression of viral replication, restoration and preservation of immune function. However, poor adherence with ART may lead to treatment failure and dea [....] » Read More
Background: Every year, Influenza A (FluA), Influenza B (FluB) and Respiratory Syncytial Virus (RSV) affect our communities and increase the number of patients in our health systems. Symptoms are similar to those of SARS-CoV-2, so diagnosis is essential to initiate an approp [....] » Read More
The antimicrobial activity of silver has long been established and is widely used clinically. The low toxicity and broad-spectrum activity of silver make it a promising candidate in the fight against resistant pathogens. N-heterocyclic carbenes (NHCs) constitute a versatile range [....] » Read More
The application of orthopedic implants in our body is associated with the possibility of infection. To have the infections under control interactions between microorganisms and implant surfaces needs to be understood. Therefore, in this presentation we consider the microbial adhe [....] » Read More
In recent years, the frequent outbreaks of infectious diseases such as SARS and COVID-19 infection have seriously threatened human life and health and socio-economic development. Since there is no specific medicine for virus infection in medicine so far, the medical community and [....] » Read More
In recent years, the frequent outbreaks of infectious diseases such as SARS and COVID-19 infection have seriously threatened human life and health and socio-economic development. Since there is no specific medicine for virus infection in medicine so far, the medical community and [....] » Read More
Introduction: Moniquira is a small town in Colombia, with 20,800 inhabitants. The main economic activity is agriculture. Leptospirosis is a zoonotic disease related with contaminated water, animals, and poverty. The aim of this paper is to describe the clinical course of the dise [....] » Read More
Background Tuberculous (TB) meningoencephalitis is a major global health problem and the most severe form of extrapulmonary TB with high mortality rate. In case Mycobacterium tuberculosis (MTB) is suspected as the etiology, early diagnosis and treatment with anti-tuberculosis dr [....] » Read More
Acute encephalitis syndrome (AES) is defined as acute onset of fever and a change in mental status (including symptoms such as confusion, disorientation, coma or inability to talk) and/or new onset of seizures (excluding simple febrile seizures) in a person of any age at any time [....] » Read More
Antimicrobial resistance is a serious issue since, by 2050, it's predicted to cause up to 10 million deaths globally (1-3). The emergence of fatal bacterial strains that are drug-resistant has been attributed to a number of factors, including the overuse of antibiotics, the s [....] » Read More
Background: In 2016, the United Nations General Assembly’s Political Declaration on Ending AIDS committed countries to the 90–90–90 targets, which aim to bring HIV testing and treatment to many people living with HIV by the end of 2020. Globally as of 2019 [....] » Read More
Severe pneumonia is one of the most common causes of sepsis and respiratory failure requiring intensive care. Despite advances in diagnostic techniques, antimicrobial therapy, respiratory support and organ support modalities; mortality and morbidity of severe pneumonia remain sig [....] » Read More
Background: During the COVID-19 epidemic, depression of medical staff showed a worsening trend year by year [1]. Interns in clinical teaching bases who are also in the front line of the fight against the epidemic are more likely to have mental health problems due to the unfamilia [....] » Read More
Background: The initiation of anti-retroviral therapy (ART) effectively restores immune function and reduces HIV-related morbidity and mortality. However, virologic failure while on ART may lead to increased morbidity and compromised quality of life. The aim of this study was to [....] » Read More
Introduction: The SARS-CoV-2 virus, the main causative agent of COVID 19 infection was first detected in the province of Hubei in Wuhan China in December of 2019 and has overwhelmed the capacity of the government and hospitals to provide healthcare services to cater to the growin [....] » Read More
Aim of study: Group B streptococcus (GBS) is a leading cause of invasive infection among neonates and infants worldwide, with two described syndromes, early onset GBS (EOGBS) disease and late onset GBS (LOGBS) disease. In our study, we investigated the incidence of invasive GBS [....] » Read More
The last 2 years after breakout of Covid pandemic there have been reported and published skin integrity complications mostly in critical care departments covid infected patients. International literature highlights the spread per 57% of facial pressure ulcer development, as conse [....] » Read More
Mucormycosis is a fungal infection caused by members of the order Mucorales, the most prominent group among zygosporic fungi (formerly ascribed to Zygomycetes). A total of 26 mucoralean species can infect humans. Among these, the highest proportions of infections are caused by Rh [....] » Read More
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected more than 760 million people globally with over 6.8 million deaths to date due to COVID-19. Alteration of the host immune system upon infection can lead to multi-organ failure followed by critical patho [....] » Read More
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has wreaked havoc on healthcare and economic systems worldwide. Despite extensive scientific research and efforts, there are still knowledge gaps regarding [....] » Read More
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Introduction NORSE is an umbrella term with different aetiologies. The usual suspects are structural lesions, infections, toxins, metabolic causes, autoimmune or paraneoplastic encephalitis. Measles is a common infection that presents with a rash and is typically self-limiting. [....] » Read More
Background: Intracranial aneurysms (IAs) are more prevalent in women than men and aneurysmal subarachnoid hemorrhage disproportionately affects postmenopausal women. These sex differences suggest estrogen protects against IA progression that can lead to rupture, but the unde [....] » Read More
Our interdisciplinary working group was motivated by the challenge of proposing tools for the fight against the sudden pandemic caused by SARS-CoV-2 in 2020 and the present. We have obtained several formulations based on chitosan, a biodegradable, non-antigenic, non-toxic, and bi [....] » Read More
Contrary to expectation, dengue incidence decreased in many countries during the period when stringent population movement restrictions were imposed to combat COVID-19. Using a Seasonal Autoregressive Integrated Moving Average model, we previously reported a 74% reducti [....] » Read More
Bacillus anthracis is the first ranked on the list of potential bioweapon agents. In case of biothreat emergency accurate and timely data resulted from on-site strain-level subtyping of the agent help to determine the origin of the used strain and provide the first bioforensic in [....] » Read More
Background: Nigeria attested to the Abuja Declaration to allocate 15% of the annual budget to health. However, current allocation is about 4.7%. This left the country extremely vulnerable to the COVID-19 pandemic. As of December 2020, Nigeria had over 87,000 confirmed cases [....] » Read More
Every virus is a parasite that cannot exist on its own and is fully dependent on its carrier. This is the basic condition of its existence. The parasite must have its host, and thus is a living cell. Based on our long-term study of BLV and HIV, we conclude that the ca [....] » Read More
Background: Even though respiratory viruses are one of the most common triggers for asthma exacerbations, not all of these viruses affect patients equally. Objective: To assess the prevalence of covid19 infection in patients presented with acute exacerbation of asthma, COP [....] » Read More
Background: Cutaneous leishmaniasis (CL) is endemic in many regions of the world, and has a significant economic and health impacts. Despite the numerous proposed therapies for this zoonotic parasitic disease. Currently, there is no definitive cure for CL. Meglumine antimony comp [....] » Read More
After a period of two seasons of absence (2020/2021) or low prevalence (2021/2022) of influenza viruses, the 2022-2023 season was characterized by high influenza activity in Bulgaria. The objectives of this study were to analyze the pattern of influenza virus circulation with res [....] » Read More
Neisseria meningitidis causes invasive meningococcal disease (IMD), which is associated with significant mortality and long-term consequences, especially among young children. The incidence of IMD in Lithuania was among the highest in European countries during the past two decade [....] » Read More
Introduction: Acinetobacter baumannii (A. baumannii) is an important nosocomial pathogen that possesses not only intrinsic resistance to many classes of antibiotics, but also has a propensity for rapid development of antimicrobial resistance during treatment. Aims & O [....] » Read More
The mosquito-borne pathogens are present worldwide, notable among these are Dirofilaria immitis, which causes heartworm disease, and Dirofilaria repens, known as the causative agent of subcutaneous dirofilariasis. These two species are unfortunately endemic throughout Europe and [....] » Read More
Purpose : Dendritic cells (DCs) are always known as professional APCs which play a crucial role in the link between innate and adaptive immunity. DCs can initiate both immunity and immunological tolerance , which means efficacy either in amelioration or exaggeration of infl [....] » Read More
Malaria remains a global health issue affecting half of the world's population. The current treatment regimen which includes artemisinin and other combination therapies is being threatened with the rapid emergence of resistance. P. falciparum under drug pressure has revealed [....] » Read More
Objective: To eliminate measles and rubella, it is critical to develop strategic and efficient immunization programs. This study aimed to evaluate the population immunity and the measles-rubella program's effectiveness by estimating anti-measles and anti-rubella IgG prevalenc [....] » Read More
Objective: To analyze the correlation between serological test results and oral clinical manifestations of patients with secondary syphilis, and to provide reference for clinical diagnosis and treatment. Methods: From January 2016 to December 2020, 30 patients with secondary [....] » Read More
Objective: To evaluate the effect of a new anti-splash mask on preventing aerosol pollution in dental clinics. Methods: The aerosol distribution characteristics in different types of splash operations were analyzed in dental clinics at first. Different splash operations were [....] » Read More
Adjuvants were described as substances used in combination with a specific antigen that produced a more robust immune response than the antigen alone. There is an urgent need for the development of new and improved vaccine adjuvants. Infectious Bronchitis (IB) is one of the most [....] » Read More
Objectives: Bloodstream infection (BSI) in children causes significant morbidity and mortality and is associated with longer hospital stays and higher healthcare costs. Our objective is to study the incidence and risk factors and identify causative organisms and outcomes of BSI a [....] » Read More
Metabolomics has been increasingly utilized in studying the host response to viral infections and for understanding the progression of multi-system disorders such as COVID-19. The analysis of metabolites in response to SARS-CoV-2 infection provides a snapshot of the end [....] » Read More
Background: Hospital Acquired Pneumonia is an important public health concern. Even with the advent of new anti-bacterials, there is an increasing prevalence of anti-microbial resistance worldwide. In particular, Ventilator Acquired Pneumonia can increase mortality risk in patie [....] » Read More
Pseudomonas aeruginosa is an opportunistic pathogen, commonly causing hospital-acquired infections in burn patients. P. aeruginosa with difficult-to-treat resistance (DTR-PA) is resistant to all of the following: piperacillin-tazobactam, ceftazidime, cefepime, aztreonam, meropene [....] » Read More
Klebsiella pneumoniae (K. pneumoniae) and Pseudomonas aeruginosa (P. Q25 aeruginosa) are the most common Gram-negative bacteria associated with pneumonia and coinfecting the same patient. Despite their high virulence, there is no effective vaccine against them. In the current stu [....] » Read More
Purpose: To evaluate the value of modified Brixia scoring system in predicting mortality in hospitalized COVID-19 patients. Methods and materials: An observational retrospective pilot study included 292 patients (178 male and 114 female) with PCR-confirmed COVID-19 infection h [....] » Read More
Background: Piringer Kuchinka’s lymphadenitis is a non-specific histological entity with multiple etiologies. We present an atypical case of visceral leishmaniasis in immunocompetent adult. A case report: 26-year-old male student in perfect health, living in an urban area [....] » Read More
Background. The novel coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2 is severe and involves multiple organs in approximately 5%-10% of patients, leading to multi-organ dysfunction and failure. Methods. Necropsy tissues (lungs, heart, liver, kidney, small-intestine) we [....] » Read More
Ticks are second to mosquitoes in disease transmission yet, significant gaps remain in our knowledge of how ticks transmit pathogens to wild animals and even humans. According to the one-health concept, wild ticks may contribute to the transmission of tick-borne diseases such as [....] » Read More
Background : Brucellosis is a common bacterial zoonotic disease with a broad spectrum of clinical manifestations. Osteoarticular involvement is frequent, with a reported prevalence ranging from 27% in nonendemic regions to 36% in endemic regions. The sacroiliac and spinal joints [....] » Read More
Cryptococcosis is a fungal potentially fatal infection, especially in its meningeal location. It’s most often due to Cryptococcus neoformans (Cn). Cellular immunosuppression, in particular the advanced stage of HIV infection, is a frequent risk factor for the onse [....] » Read More
Title : MVA-based virotherapies in the treatment of infectious diseases
Genevieve Inchauspe, ImmunResQ Department, France
A famous milestone in the vaccine field has been the first successful vaccination against smallpox in 1798 by Edward Jenner. Using the vaccinia cowpox virus, Jenner was able to protect vaccinees from variola or smallpox. The Modified Virus Ankara (MVA) poxvirus strain has been on [....] » Read More
Title : The rationale of ethanol inhalation for disinfection of the respiratory tract in SARS-CoV-2-positive asymptomatic subjects
Pietro Salvatori, Private Practice, Italy
The severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic is a major health concern affecting socio-economic lives. As with other highly contagious diseases, it is of utmost importance to identify and treat the healthy carriers or positive asymptomatic subjects (P [....] » Read More
Title : Rapid, isothermal detection of Zika virus: a potential alternative to RT-PCR
Rickyle Christopher Balea, The University of the Sunshine Coast, Australia
Zika virus (ZIKV) is a re-emerging flavivirus that poses a significant public health threat. ZIKV exhibits a wide array of non-vector borne human transmission routes, such as sexual transmission, transplacental transmission and blood transfusion. Detection and surveillance of ZIK [....] » Read More
Title : No cold chain molecular workflow for detecting and differentiating plasmodium
Sara Sentre Domingo, CerTest Biotec, Spain
Background Malaria (or paludism), is a mosquito-borne parasitic disease caused by Plasmodium, is a leading cause of death and disease in many developing countries. The objective of this study was to determine the clinical performance of VIASURE Malaria Real Time PCR Detection Ki [....] » Read More
Title : Carriage of neisseria meningitidis among university students living in residential colleges, Dunedin, New Zealand
Susan Jack, University of Otago, New Zealand
Invasive meningococcal disease is a severe disease caused by Neisseria meningitidis that can present as septicaemia or meningitis and may lead to disability or death. Nasopharyngeal carriage of N. meningitidis may occur in up to 15% of the general population with a higher p [....] » Read More
Title : Therapeutic intervention of Bunyavirus induced hemorrhagic fever and cardiopulmonary disease
Mohammad Mir, Western University of Health Sciences, United States
Viruses from different families in the order Bunyavirales contains highly contagious and deadly viruses, having no cure at present. For example, hantaviruses from the family Hantaviridae are negative stranded emerging RNA viruses and category A pathogens that cause serious illnes [....] » Read More
Title : Insecticide resistance and use of household insecticides for personal protection: Insights from vector-borne disease outbreaks
Walter Fabricio Silva Martins, Liverpool School of Tropical Medicine, United Kingdom
Aedes aegypti is the most important vector of at least four fatal and/or debilitating arboviruses (dengue, chikungunya, yellow fever and Zika). Insecticide-based approaches remain the major intervention to minimize vector-borne disease burden across the diseases. In Brazil [....] » Read More
Title : Control of C. difficile-associated disease using a Multimodal Intervention
Namiz Damani, Betsi Cadwaladr University Health Board, United Kingdom
Clostridioides difficile has been recognized as the most common cause of hospital-acquired diarrhoea. The symptoms vary from mild diarrhoea to fulminating infection, leading to pseudomembranous colitis and death. Since 2003, C. difficile-associated disease (CDAD) h [....] » Read More
Title : Efficacy and safety of inhalation of nebulized ethanol in covid-19 treatment. A randomized clinical trial
Pietro Salvatori, Private Practice, Italy
Background: This study was designed to evaluate the efficacy and safety of nebulized ethanol (EtOH) in the treatment of COVID-19. Methods: A RCT of 99 symptomatic and RT-PCR-positive patients admitted to a hospital receiving Remdesevir-Dexamethasone was conducted. They were ra [....] » Read More
Title : Spatio-temporal patterns of dengue incidence and their associated factors, Brazil, 2000-2018
Patricia Marques Moralejo Bermudi, University of Sao Paulo, Brazil
Dengue is a neglected tropical disease. This arbovirus is an important public health problem and has a great economic impact, especially in emerging countries. Globally, the incidence of dengue has expanded abruptly in recent decades, potentially associated with climatic factors. [....] » Read More
Title : Molecular screening for intestinal protozoan and fungal pathogens and first subtyping of blastocystis spp. in hemodialysis patients in Slovakia
Elena Hatalova, Pavol Jozef Safarik University, Slovakia (Slovak Republic)
Blastocystis spp., Cryptosporidium spp., Giardia intestinalis and Microsporidia spp. are protozoan and fungal intestinal pathogens in immunocompromised individuals, causing symptomatic or asymptomatic infections, which are usually undiagnosed. Uremia in hemodialysis patients with [....] » Read More
Title : Inhibitory effects of limonene on candida albicans virulence-related traits
Saiema Ahmedi, Jamia Millia Islamia, India
A major global problem is the severe toxicity of conventional antifungal medications and multidrug resistance. Investigation of new substances with outstanding therapeutic potential is necessary. In this work, the antifungal potential of limonene, a secondary metabolite present i [....] » Read More
Title : Onchocerciasis drug development: From pre-clinicals to humans
Adela Ngwewondo, Institute of Medical Research and Medicinal Plants Studies, Cameroon
Twenty diseases are recognized as neglected tropical diseases (NTDs) by World Health Assembly resolutions, including human filarial diseases. The end of NTDs is embedded within the Sustainable Development Goals for 2030, under target 3.3. Onchocerciasis afflicts approximately 20. [....] » Read More
Title : Diagnosis of suspicious skin lesions in mpox times
Sara Sentre Domingo, CerTest Biotec, Spain
Background: The appearance of skin lesions of viral nature can be a symptom of infection or reactivation of the herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), varicella zoster virus (VZV), T. pallidum or mpox virus infection. Given the ability of t [....] » Read More
Title : The burden of human parechoviruses on children in oman
Aws Sami Sulaiman Al-Farsi, Sultan Qaboos University, Oman
Objectives To study the burden, clinical and laboratory features and outcome of Human Parechoviruses (HPeVs) infection among children managed at a tertiary hospital in Oman. Methods: This is a retrospective study of children (< 18 years of age) with molecular proven HPeV in [....] » Read More
Title : Clinical evaluation of Mpox virus detection by real time PCR
M Esperanza Teresa-Rodrigo, CerTest Biotec, Spain
Background: In an increasingly globalized and interconnected world, the outbreak of an infectious disease in one country can become a worrying health emergency for the whole world. A recent example is the 2022 Mpox outbreak affecting multiple areas across the world. In this [....] » Read More
Title : Sternal wound infection following open heart surgery: Incidence, risk factor, pathogen, and mortality
Mohsin Khared, King Abdulaziz University, Saudi Arabia
Surgical site infections (SSI) are a significant cause of morbidity and mortality after surgery. Due to its high morbidity and mortality rates after open-heart surgery, sternal wound infection (SWI) is one of the most important consequences to avoid and manage. Staphylococcus spe [....] » Read More
Title : Predicted coverage by 4CMenB and MenB-Fhbp vaccine against invasive serogroup B neisseria meningitidis isolated from 2017-2019 in Lithuania
Milda Pleckaityte, Vilnius University, Lithuania
The incidence of invasive meningococcal disease (IMD) in Lithuania was among the highest in Europe during the past two decades reaching an average of 2.24 cases/100,000 population. The vast majority of IMD cases were caused by serogroup B meningococci. In 2018, the only four-comp [....] » Read More
Title : Effect of dietary intervention on the prevalence of asymptomatic malaria among 6-18-month-old children in rural Malawi
Hany Sady Shokry Redah, Tampere University, Finland
Background: The complex interaction between malaria and undernutrition leads to increased mortality and morbidity rate among young children in malaria-endemic regions. Results from previous interventions suggest that improving nutritional status of young children may reduce [....] » Read More
Title : Engystol may reduce lung pathology in SARS-CoV-2 infected hamsters: A pilot study
Kathrin Weyer, Heel GmbH, Germany
Despite the introduction of vaccines and new anti-viral therapies, the COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to be a serious global public health crisis. The emergence of new viral variants that escape protection from [....] » Read More
Title : Comparing climatic and socioeconomic factors inside and outside the high-risk spatial clusters of chikungunya and zika in Brazil
Raquel Gardini Sanches Palasio, University of Sao Paulo, Brazil
Chikungunya and Zika diseases are caused by viruses from the families Togaviridae and Flaviviridae, respectively. These diseases are subject to climate change, as temperature and precipitation variations can affect the survival, reproduction and distribution of the virus and its [....] » Read More
Title : Exploring the impact of Plectranthus amboinicus L. extracts on antioxidant system and cell membrane integrity of P. aeruginosa PA01 and S. aureus NCTC8325
Sheeba S Sawant, University of Wolverhampton, United Kingdom
Background: Medicinal plants have drawn attention due to their antibacterial properties against several disease-causing bacteria. Plectranthus amboinicus has been studied to possess various biological properties that can be explored to attain new therapeutics to combat such disea [....] » Read More
Title : The potential of guanidino and amidopropyl dimethylamine compounds as topical treatments for diabetic foot ulcer infections
Michael Ansah, University of Wolverhampton, United Kingdom
Diabetic foot ulcer (DFU) infections caused by multidrug resistant (MDR) organisms cost approximately 1% of the annual NHS budget, mainly through pre/post op management of complications/amputations. The aim of this study is to investigate the potential of guanidino based compound [....] » Read More
Title : Chikungunya and zika high-risk co-occurrence clusters in Brazil: Is there a perfect overlap?
Raquel Gardini Sanches Palasio, University of Sao Paulo, Brazil
Chikungunya and Zika diseases are transmitted by the same vectors, Aedes aegypti and Ae. albopictus, and possibly the transmission is related to the same environmental and socioeconomic factors. In other words, a simultaneous space and time occurrence is expected. In addition, th [....] » Read More
Title : Development of a syndromic molecular diagnostic assay, using barcoded magnetic bead technology for tick-borne pathogens
Sheema Mir, Western University of Health Sciences, United States
The infectious disease diagnostics often depends on costly serological testing with poor sensitivity, low specificity, and long turnaround time. Here In this manuscript, we demonstrate the proof of the principle for simultaneous detection of two tickborne pathogens from a single [....] » Read More
Title : Lack of association between YEASTONE antifungal susceptibility of cryptococcus meningitis cerebrospinal fluid isolates and risk factors for poor prognosis
Jeng How Yang, New Taipei Municipal TuCheng Hospital, Taiwan
Background: Cryptococcal meningitis (CM) is associated with high mortality. The relation between antifungal susceptibility and treatment outcomes is not well characterized. There is paucity of surveillance data of cerebrospinal fluid (CSF) isolates of cryptococcus investigated wi [....] » Read More
Title : The activity of PHMB and other guanidino containing compounds against Acanthamoeba
Dharanga Rumeshi Ratnayake, University of Wolverhampton, United Kingdom
In recent years, a rise in the number of contact lens users in the UK and worldwide coincided with an increased incidence of microbial keratitis. The aim of this study was to investigate the antimicrobial activities of polyhexamethylene guanidine (PHMG), polyaminopropyl biguanide [....] » Read More
Title : Investigation of the immunomodulatory effects of cecropin A on a primary hepatic coculture of chicken origin
Rege Anna Marton, University of Veterinary Medicine, Hungary
The indiscriminate use of conventional antibiotics has contributed to the global spread of antibiotic resistance, therefore, there is an urgent demand to search for alternatives that can provide a novel antimicrobial mode of action. Finding a potential replacement is crucial for [....] » Read More
Title : The impact of pneumococcal conjugate vaccine on pneumococcal nasopharyngeal ecology in children 2 months through 5 years
Tafaani Khan, Boston Medical Center, United States
This study evaluates the ecology of Streptococcus pneumoniae (SP) nasopharynx (NP) colonization in response to the pneumococcal conjugate vaccines, specifically 7- Valent Pneumococcal Conjugate Vaccine (2000-2009), 13-Valent Pneumococcal Conjugate Vaccine (2010-2023) and 20-Valen [....] » Read More
Title : Screening the Medicines for Malaria Venture (MMV) Pandemic Response Box chemical library on Caenorhabditis elegans identifies re-profiled candidate anthelmintic drug leads
Marina Nick, Division of Medicine, UCL, United Kingdom
The 3 major classes of soil transmitted helminths (whipworm, hookworm and Ascaris) affect 1.5 billion people worldwide mostly in poor countries, where they have adverse effects on child development, nutrition, and the work capacity of adults. Although there are drugs effective on [....] » Read More
Title : Concept elicitation, cognitive debriefing and usability testing of COVID symptoms diary
Clara Fehrmann, SPRIM US LLC, United States
Objective: COVID-19, caused by a coronavirus, SARS-CoV-2, has been the cause of the global pandemic from 2020-2022. Due to COVID-19’s novelty, there exist no validated patient reported outcome (PRO) tools that allow for proper evaluation of patient infection seve [....] » Read More